Supplemental Methods from Glucuronide-Linked Antibody–Tubulysin Conjugates Display Activity in MDR<sup>+</sup> and Heterogeneous Tumor Models
Patrick J. BurkeJoseph Z. HamiltonThomas A. PiresHolden W. H. LaiChristopher I. LeiskeKim K. EmmertonAndrew B. WaightPeter D. SenterRobert P. LyonScott C. Jeffrey
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<p>Description of stability experiment, rat tolerability, and chemistry experimentals.</p>Keywords:
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Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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The diastereoselective conjugate addition of an organocopper reagent to a chiral racemic olefinic amido ester has been used as the key step in a formal total synthesis of paroxetine.
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Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Abstract The silylstannylimine (I) reacts with butyllithium and the copper(I) derivatives (II) to produce the iminomethylcuprates (III) which are coupled with the enones (IV) or (VII).
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Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Abstract [providing the corresponding addition products in high yields and a high value of enantioselectivity]
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Abstract Reaction of the aminothiophenol (I) with benzaldehyde (II) affords the title compound (III), which is used as reducing agent.
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