Supplementary Table S1 from Aurora A Is Critical for Survival in HPV-Transformed Cervical Cancer
Brian GabrielliFawzi BokhariMax V. RanallZay Yar OoAlexander J. StevensonWeili WangMelanie MurrellMushfiq Hassan ShaikhSora FallahaDaniel ClarkeMadison J. KellyKarin SedeliesMelinda E. ChristensenSara McKeeGraham R. LeggattPaul LeoDubravka ŠkalameraH. Peter SoyerThomas J. GondaNigel A.J. McMillan
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<p>Primary screening daat from kinome siRNA screen</p>Keywords:
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Cervical cancer is a type of cancer that occurs in the cells of the cervix. It is second most common cancer in developed regions and is one of the most common causes of cancer death in developing countries. In India, the cervical cancer ranks as the first most frequent cancer and the first most frequent cancer among women between 15 and 44 years of age. It is by far the most common Human papillomavirus infection (HPV) related disease and other risk factors includes smoking, a weak immune system, birth control pills, starting sex at a young age and having many sexual partners, but these are less important. In the investigation the serum biochemical profile of the cervical cancer patients undergoing treatment at Regional Cancer Hospital and Research Centre, Zemabawk, Aizawl, Mizoram was estimated. The serum levels of triglyceride, alkaline phosphatase, gamma glutamyltransferase and chloride are on higher side while the observed level of cholesterol, creatinine and potassium are on higher margin of the normal reference range. The level of serum HDL-cholesterol was lower while the levels of magnesium and sodium were on lower margin of the normal reference range.
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Cancer is one of the biological threats to men and women. It is characterized by an abnormal growth of cells, which has the ability to invade the adjacent tissues and organs. There are various types of cancer peculiar to women, among which cervical and breast cancer are highly reported. Next to breast cancer, cervical cancer remains the most common in women worldwide. Cervical cancer is the fifth most common cancer of the world and third most common cancer in the women globally. Cervical cancer is the second leading cause of cancer bereavements in women aged 15-44 years in India. Mortality due to cervical cancer is greater in Indian Women than in Women of other country, that is 85% of cases present in advanced and late stages when diagnose has been made. According to global cancer statistics, cervical cancer is now the third most commonly diagnosed cancer and the fourth leading cause of cancer death in females worldwide. More than 86% of these cases occur in developing countries. India has a population of 432.20 million women aged 15 years and above who are at risk of emerging cervical cancer. Recent estimates indicate that every year 122,844 women are diagnosed with cervical cancer and 67,477 die from the disease, it indicates that every hour 8 women are dying due to this cancer (WHO 2012). Human Papilloma Virus (HPV) is the most common sexually transmitted infection which causes a wide range of disease from warts to cancer. HPV is a double stranded DNA virus, more than 10 human and animal papilloma virus genotypes have been characterized and sequenced. Approximately 30 HPVs infect the ano-genital tract, of these 15 HPV types are classified as high risk types (HPV types 16, 1, 31, 33, 35, 39, 5, 51, 52, 56, 58, 59 68, 73, and 82) and they are associated with high grade cervical cancer, precancerous lesions and invasive cervical cancers. HPV vaccine is one of the recommended interventions for cervical cancer World-wide .After implementation of National cervical Screening Programme in Australia in 1991, the incidence of cervical cancer reduced from 18% (1991-2002) to 6-7% (2014) per 100,000 populations. The focus on detection and prevention of cervical cancer must be emphasized in a highly populated country like India. A national HPV vaccination program appears to be practically possible as compared to screening program in India.
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Uterine cancer
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objective: To evaluate the efficacy and side effect of interventional chemotherapy and embolization with radiotherapy in treatment of advanced cervical cancer. Methods: 8 cases of advanced cervical cancer received interventiondl chemotherapy and embolization with radiotherapy. Results: 3 of 8 cases with decreased grade underwent surgery.5 of 8 cases improved and then underwent radiotherapy.The major side effect included leucocytopenia,gastrointestinal response and embolization syndrom.Conclusion: Interventional combined therapy is effective in decreasins grade and being ready for additional surgery.It is effective method in treating advanced cervical cancer.
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A cervical cancer is one of the most common cancers among the women in many developing countries. It is estimated that around 83% of all the new cases of cervical cancer and 85% of all the deaths occur in the developing countries. Cervical cancer is the commonest malignancy among women in India. The cervical cancer contributes around 12% of all types of cancers among the women.
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Intraoperative radiation therapy
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Sir, With a death toll of approximately 237,500 women each year, cervical cancer is the primary cause of cancer deaths among women in many developing countries.[1] Cancer of the cervix is the most common cancer among women in India. It has been estimated that 100,000 new cases of cancer of the cervix occur in India every year and 70% or more of these are stage III or higher at diagnosis.[2] This clearly indicates the lack of awareness and facilities for cervical cancer screening in India. With the Food and Drug Administration's approval of the vaccine Gardasil, marketed by Merck and Co. Inc. in USA and with a similar vaccine in the name of Cervarix by the GlaxoSmithKline waiting for approval sometime later this year the future may seem to hold some promise for the crusade against the second biggest cancer killer in women. The vaccine prevents infection with certain types of human papilloma virus mainly types 16 and 18 which are responsible for 70% of the cervical cancer cases. Requiring three doses in over six months with a catalogue price of $120 per dose, the total cost of vaccination is expected to be around $ 360, well out of the reach of women in developing countries.[3] Moreover the vaccine may not protect people already infected with HPV and may increase their risk of the kind of lesions that can lead to cervical cancer. The target age for receiving Gardasil has been kept low (girls and women between 9 to 26 years of age) because the vaccine works best when given to girls before they begin having sex and run the risk of HPV infection. So it is clear that the vaccine can in no way be considered a replacement for the standard screening test which remains the gold standard for early detection and better prognosis of the killer disease.[4] Thus in countries like India where a huge section of the population live below poverty line and where awareness among women for cervical cancer control and treatment remain very limited even years after implementation of the National Cancer Control Program in 1975 the recent breakthrough in the global war against cervical cancer does not seem to have much impact. Moreover with the lack of high level government efforts to promote organised screening programmes for cervical cancer despite acknowledging the importance of the screening programmes the future of cervical cancer continues to remain bleak in India. It is overdue that the government responds to the need of the hour and strengthens information, education and communication efforts on cervical cancer along with providing widespread screening facilities.
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Objective To evaluate preoperative transarterial chemoembolization in treating locally advanced cervical cancer and to observe the pathological changes.Methods During the period of Aug.2002-Dec.2009,Thrty-five patients with pathologically proved cervical cancer were enrolled in this study.Including 14 cases of IB2,5 cases IIa and 16 cases IIb.Preoperative transarterial chemoembolization was performed with cervical cancer.The antineoplastic druge included cisplatin,epirubicin and BLM.In all patients,interventional arterial infusion chemotherapy was carried out before the embolization of bilateral tumor-feeding arteries with gelfoam was made.Results Thrty-five patients underwent radical resection surgery after receiving 1 times of chemoembolization.Pathologically,massive necrosis and lymphocytic infiltration were found within the tumor.Conclusion Preoperative transarterial chemoembolization is a safe and effective adjunctive means for the treatment of cervical cancer,can effectively decrease the tumor size and reduce blood loss during operation,which is very helpful for the subsequent radical hysterectomy.
Epirubicin
Transcatheter arterial chemoembolization
Infiltration (HVAC)
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Introduction Cervical cancer has become one of the major causes of cancer death among women worldwide. This can be cured in its earlier stage. For most of the cases it shows symptoms only in the advanced stages. Cervical cancer is a cancer arising from the cervix. Cancer is due to the abnormal gr
Cancer Detection
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