Supplementary Table S1 from PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer
Ruosi YaoHao JiangYuhui MaLiping WangLin WangJuan DuPingfu HouY. GaoLi ZhaoGuannan WangYu ZhangDongxu LiuBaiqu HuangJun Lü
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<p>Expression of PRMT7 in normal breast tissues and breast carcinoma</p>Keywords:
Breast cancer metastasis
Breast carcinoma
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Metastasis is incontrovertibly linked to poor cancer patient survival. Cancer treatments that inhibit metastasis are predicted to improve cancer patient outcomes by preventing cancer dissemination. However, to control metastasis in patients necessitates an understanding of the biological drivers of metastasis. Drivers of metastasis can be thought of as factors that promote tumour dissemination, required at least for a part of the metastatic process. Yet, presently specific molecular drivers of metastasis largely remain unidentified, and very little evidence for ubiquitous metastasis-specific driver gene mutations has been identified to date (1,2).
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An outline of the mechanism of cancer metastasis is presented from a molecular biological point of view, and the present state and future possibility of prediction about cancer metastasis in clinical cases is described. Cancer metastasis is developed through multiple steps. With the progress of studies on the mechanism of metastasis, the effort to predict cancer metastasis in clinical cases has progressed. Metastasis is formed in concern with many factors, so it may be highly difficult to explain clinical metastasis by a single factor. It will be important to comprehensively put many factors into consideration. For the preoperative diagnosis of the potential of metastasis, examination of specimens from endoscopic biopsy or blood serum will become more important.
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Metastasis is one of the most distinct but complicated biological phenomena in cancer. It is hard to decide the most important prospect which must be performed at the present as well as in future studies on cancer metastasis. However, the final goal of the studies on metastasis can be simply concluded as that metastasis should be prevented before dissemination. In this review, we discussed several points to do research in metastasis.
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The spread of cancer cells in the body -'metastasis,' is a challenging issue for cancer patients and for cancer research. From a clinical point of view, the majority of the cancer-related deaths in patients who suffer from solid cancers are metastasis-related. Although this life threatening consequence in cancer is recognised almost immediately at the time of diagnosis, the current-state-of-knowledge on the mechanisms and effective ways to combat cancer metastasis in clinical settings is far from being realized. Thus, making the necessity of continuing research into cancer metastasis evermore demanding and critical. This issue of the journal is directed toward consideration of some of the salient aspects of cancer metastasis, with a focus on recent progress of the molecular and cellular mechanisms of cancer invasion and metastasis.
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Cancer as an historical disease is known to occur since several hundred years and still prevails till date as one of the most feared diseases. Its occurrence and/or progression are considered as the outcome of the series of accumulated ocogenic changes in the cell those transform it from benign to invasive or metastatic. It has been observed that most of the metastatic cancers are not curable and the available drugs focus on steadying the tumour growth to prevent further metastasis. Metastasis remains the cause of around 90% of the cancer deaths. Fundamental understanding of metastasis and recent advancements in metastasis driven cancer research may help to strengthen and bring in practice the new and advanced approaches for cancer treatment. In view of this, we review in detail the molecular mechanism of metastasis, problems in diagnosing and treating metastasis, and recent developments in cancer biology. Future efforts in order to unveil the unpredicted and uncontrolled metastasis of cancer cells have also been summarised.
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Epithelial-mesenchymal transition( EMT) is the phenomenon that epithelial cells transform to motile mesenchymal cells in the specific microenvironment. This phenomenon can be observed in invasion and metastasis of primary hepatocellular carcinoma. Therefore,this article will not only review EMT and it's regulatory factors,but also the role of EMT in the invasion and metastasis of primary liver cancer.
Liver Cancer
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