Figure S4 from Gut Microbiome Components Predict Response to Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer: A Prospective, Longitudinal Study
Yuxi YiLijun ShenW. ShiFan XiaHui ZhangYan WangJing ZhangYaqi WangXiaoyang SunZhiyuan ZhangWei ZouYang WangLingyi ZhangJi ZhuAjay GoelYanlei MaZhen Zhang
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<p>Supplementary figures showing that baseline gut microbiome correlated with therapeutic response to nCRT in LARC patients.</p>Keywords:
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Human Microbiome Project
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Background Humans and animals living in close proximity may share microbiome constituents at the household level because of daily domestic contact. Such sharing could affect enteric and metabolic functions of the gut microbiome of humans and livestock living in such households. We sought to characterise the microbiome of children, cattle, chickens, and environmental surfaces within households in western Kenya to determine the degree of microbiome sharing.
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The increasing prevalence and severity of pediatric food allergies (FA) demands innovative preventive and therapeutic strategies. Emerging evidence suggests a pivotal role for the gut microbiome in modulating susceptibility to FA. Studies have demonstrated that alteration of gut microbiome could precede FA, and that particular microbial community structures early in life could influence also the disease course. The identification of gut microbiome features in pediatric FA patients is driving new prevention and treatment approaches. This review is focused on the potential role of the gut microbiome as a target for FA prevention and treatment.
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Diverse evidence has suggested that the gut microbiome is closely associated with overall human health. Modulation of the gut microbiome through nutritional intervention is recognized as a robust and attainable strategy to prevent disorders/diseases and improve human health. However, universal dietary recommendations demonstrated to have different, sometimes even opposite, effects due to the considerable inter-individual variability between subjects, especially in the gut microbiome. Hence, implementation of personalized nutrition or other treatment strategies have been suggested to tackle the individuality problem. A first step into this direction includes the stratification of subjects into specific groups based on their gut microbiome. The gut microbiome could serve as a pool of potential biomarkers for distinguishing "responders" and "non-responders" to specific treatments, which subsequently can be used to classify subjects with ambition to increase treatment efficacy. In this review, we explain the need for human gut microbiome stratification, introduce the concepts and show with specific examples potential options of microbiome-based stratifications. Finally, we propose a strategy for how microbiome-based stratification can be introduced to obtain improvements in dietary efficacy that can be implemented in real-life settings.
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Gut microbiome composition or circulating microbiome-related metabolites in patients with heart failure (HF) have not been investigated at different time points (i.e., in the decompensated (Decomp) and compensated (Comp) phases).
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