Applications of Artificial Intelligence in Lung Carcinoma: Bibliometric Analysis for Knowledge Mapping and Emerging Trends (2000-2023)
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Bronchial complications, along with development and progression of chronic dysfunction on the background of chronic rejection, are factors that reduce the quality and life of lung and heart-lung recipients. They also increase the frequency of hospitalizations. Application of cryotechnology is based on the contact effect of extremely low temperatures on organs and tissues using a cryoprobe. This article demonstrates the experience of using cryotechnology in the diagnosis and treatment of complications in lung and heart-lung recipients.
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We studied the effects of alterations in lung fluid volume on growth and maturation of the fetal lung. In a chronic fetal sheep preparation, right fetal lung volume was decreased by drainage of lung fluid while the volume of the left lung was expanded by mainstem bronchus ligation leading to lung fluid retention. After an experimental period of 25 d (from 105 to 129 d of gestation, term = 145 d), the right (deflated) lung was significantly hypoplastic and contained less DNA than the controls; 175.15 +/- 55.18 vs. 346.77 +/- 61.97 mg, respectively; P less than 0.001. In contrast, the left (expanded) lung was significantly hyperplastic and contained more DNA than the controls; 390.74 +/- 103.53 vs. 238.85 +/- 33.32 mg, respectively; P = 0.001. Biochemical indices of lung maturation, including total phospholipids, phosphatidylcholine, and disaturated phosphatidylcholine content expressed per unit of tissue DNA, were no different when comparing the hypoplastic, hyperplastic, and control lungs. These findings demonstrate that fetal lung cell multiplication is influenced by local distension with lung fluid, while the biochemical maturation of fetal lung surfactant is under systemic control.
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Litter
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Whitsettらのグループは, ヒトサーファクタント蛋白B遺伝子プロモーターの解析に関する報告以降, thyroid transcription factor-1 (TTF-1) , hepatocyte nuclear factor-3 (HNF-3) が, 胎児期に肺上皮細胞で産生が開始される肺上皮細胞特異的遺伝子の転写制御に重要な役割を果たすことを次々に明らかにした. また, それぞれの遺伝子のノックアウトマウスの表現型からTTF-1, HNF-3βが肺の初期発生においても重要な転写因子として考えられるようになった. 最近では, 新生児の気管支肺異形成 (新生児慢性肺疾患) の病態に, TTF-1とHNF-3が重要である可能性を指摘する報告, 肺損傷の修復過程におけるHFH-8 (FOXf1) の重要性に関する報告も認められる.
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Journal Article Human Lung Organ-Specific Antigens on Normal Lung, Lung Tumors, and a Lung Tumor Cell Line Get access Richard Akeson Richard Akeson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 58, Issue 4, April 1977, Pages 863–869, https://doi.org/10.1093/jnci/58.4.863 Published: 01 April 1977 Article history Received: 28 April 1976 Accepted: 20 September 1976 Published: 01 April 1977
Human lung
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The relationship between lung liquid flow and fetal lung development has been studied at the cellular level using ultrastructural techniques. Continuous in utero tracheal ligation and drainage (over a period of 21-28 days) both result in malformations of the developing fetal lamb lung. Ligated lungs are larger, and drained lungs are smaller, than normal lungs at a similar gestational age. These changes are not merely due to altered lung liquid volume, but actual tissue growth thas been affected. Future alveolar wall thinning is enhanced in ligated lungs and inhibited in drained lungs, whilst the presence of differentiated alveolar type II cells (probably related to surfactant production) is decreased in ligated lungs and markedly enhanced in drained lungs. These results indicate the importance of fetal lung liquid in the regulation of pulmonary development in the fetus.
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Thorax (insect anatomy)
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By labelling anti-rat-lung serum with radioiodine and injecting it into rats, it was found that the anti-rat-lung serum contained antibody which localized specifically in the lung. It also contained antibody which cross-reacted with and localized in the kidney. Anti-rat-brain, -liver, and -heart sera were also investigated and showed no specific localization, but these experiments were considered inconclusive.
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We studied the postoperative course of lung volumes in 32 heart-lung transplant recipients relative to the predicted total lung capacity of the individual donors, to assess the degree of inaccuracy likely to result from the radiological method of matching of donor and recipient lung sizes. There was a tendency for recipients with large preoperative lung volumes--from, for example, emphysema--to receive smaller lungs, while those with smaller volumes from pulmonary vascular disease received bigger donor lungs, but no immediate problems were incurred. After an initial fall in total lung capacity, the postoperative value of the total lung capacity approached the recipients' pretransplant value about one year after the operation irrespective of the size of the donor lungs. This suggests that chest wall compliance is the major determinant of postoperative lung volume and not the donor lung size or compliance. Exact matching of donors' and recipients' lung sizes may not be necessary, and if required can be simply achieved by comparing the measured total lung capacity in the recipient with the predicted value of the donor based on sex, age, and height.
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Objective To observe the change of immunologic expression of tumor necrosis factor-alpha(TNF-α) and interleukin-6(IL-6) in lung tissues of model rats with insufficiency of the lung-qi and lung-yang.Methods Health wistar rats were divided into control group,insufficiency syndrome of the lung-qi and lung-yang group.The models of insufficiency of the lung-qi were induced by the smoke of saw power and cigarettes for consecutive 7 weeks.The model rats of insufficiency of the lung-yang were placed into the fridge for 2 hours per time for 7 weeks after smoking 30 minutes,every day was 2 times.At the end of 7 weeks,the lung tissue was taken for observing pathologic picture and detecting the immunologic expression of TNF-α and IL-6 by SABC technique of immunohistochemistry.Results Compared with control group,the total positive area and average optical density of TNF-α and IL-6 were obviously increased in insufficiency syndrome of the lung-qi and lung-yang group(P0.05 or P0.01).Compared with insufficiency syndrome of the lung-qi group,the total positive area of TNF-α was obviously increased(P0.05).Conclusion TNF-α and IL-6 were involved in the pathological process of insufficiency of the lung-qi and lung-yang,and may promote the process from insufficiency of the lung-qi to insufficiency of the lung-yang.
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