Figure S7 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
George A. WardZhiqiang ZhangSimone JueligerIlya S. PotapovMatthew P. DavisAdam R. BoxallJason TaylorHarold KeerAndrea BiondoJohn F. LyonsMartin SimsTomoko Smyth
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<p>Figure S7. Additional in vivo PD data. (Refers to Figure 5)</p>Keywords:
Priming (agriculture)
T-Cell Lymphoma
T-Cell Lymphoma
Follicular lymphoma
Large cell
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Objective To study the relationship of Epstein Barr virus (EBV) and T cell lymphoma.Methods Sixty cases of T cell lymphomas were examined for the presence of EBV using in situ hybridization for EBV encoded RNA (EBERs).Results EBERs were detected in tumor cells in 37(69.8%) of 53 cases with peripheral T cell lymphoma,but in none of seven cases of precusor T lymphoblastic lymphoma.The total detected EBERs were 37(61.6%) in 60 cases of T cell lymphomas.By Revised European Amercan Lymphoma(REAL) classification,EBERs were detected in 2/2 angioimmuno blastic T cell lymphoma,17/18 angiocentric lymphoma, 4/6 anaplastic large cell lymphoma and 14/27 peripheral T cell lymphoma,unspecified (51.9%).The frequency of EBERs among the extranodal peripheral T cell lymphoma was higher than the nodal ( P 0.01),there was no significent correlation with the sex,age and clinical stage.Conclusion This study indicated that high incidence of EBV was observed in peripheral T cell lymphoma,with predilection for angiocentric lymphoma and extranodal presentation.
Peripheral T-cell lymphoma
T-Cell Lymphoma
Anaplastic large-cell lymphoma
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objective:To analyze the clinical manifestation,diagnosis,mis-diagnostic reasons and treatment method of orbital NK/T cell lymphoma.Methods:The literature was reviewed and 2 patients with orbital NK/T cell lymphoma were collected.Then we analyzed the diagnosis,differential diagnosis and therapy of orbital N K/T cell lymphoma.Results:Orbital NK/T cell lymphoma was one kind of relatively rare,new reported extra-nodal lymphoma,which was usually mis-diagnosed as conjunctivitis,idiopathic orbital inflammation,periorbital area inflammation.The orbital NK/T cell lymphoma and nasal NK/T cell lymphoma shared similar stopathology,immunopathology.Conclusions:The orbital NK/T cell lymphoma shows distinctive cliniopathologic,immunophenotypic and characteristic CT or MRI manifestations.The patients are diagnosed difficultly in the early stage,presented highly aggressive clinic course and a very high lethality.
T-Cell Lymphoma
Aggressive lymphoma
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Objective To compare the detection rate of Epstein-Barr virus latent membrane protein 1 (LMP1) 30 base pair deletion in extranodal nasal type NK/T-cell lymphoma with that in chronic inflammation of nasopharynx and tonsillitis; and to analyze the prognostic significance of LMP1 deletion in extranodal nasal type NK/T-cell lymphoma.Methods Polymerase chain reaction was used to detect the deletion of LMP1 in 55 cases of extranodal nasal type NK/T-cell lymphoma and 19 cases of chronic inflammation of nasopharynx and tonsillitis.Follow-up information of 1 to 58-month duration was available in 33 patients.Results In all the 55 extranodal nasal type NK/T-cell lymphoma cases studied, 9 cases contained the wide-type or predominantly wide-type LMP1.On the other hand, 46 cases contained the deleted or predominantly deleted LMP1.In the non-lymphoma control group, 16 cases contained the deleted or predominantly deleted LMP1.However, no statistically significant difference was found in the detection rate of 30 base pair deleted LMP1 between extranodal nasal type NK/T-cell lymphoma and control group (P0.05).The prognosis of deleted or predominantly deleted LMP1 in extranodal nasal type NK/T-cell lymphoma was worse.Conclusion Though 30 base pair deletion of Epstein-Barr virus LMP1 may not be an important pathogenetic step in extranodal nasal type NK/T-cell lymphoma, it may play some role in tumor progression.
T-Cell Lymphoma
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T-Cell Lymphoma
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T-Cell Lymphoma
Ratón
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Background The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells and DCs, which can give concurrent activation of T cells and HIV transmission. Methodology The study aim was to establish whether DCs pulsed with HIV-1 could prime HIV-specific T cell responses and to characterize these responses. Both infectious and aldrithiol-2 inactivated noninfectious HIV-1 were compared to establish efficiencies in priming and the type of responses elicited. Findings Our findings show that both infectious and inactivated HIV-1 pulsed DCs can prime HIV-specific responses from naïve T cells. Responses included several CD4+ and CD8+ T cell epitopes shown to be recognized in vivo by acutely and chronically infected individuals and some CD4+ T cell epitopes not identified previously. Follow up studies of acute and recent HIV infected samples revealed that these latter epitopes are among the earliest recognized in vivo, but the responses are lost rapidly, presumably through activation-induced general CD4+ T cell depletion which renders the newly activated HIV-specific CD4+ T cells prime targets for elimination. Conclusion Our studies highlight the ability of DCs to efficiently prime naïve T cells and induce a broad repertoire of HIV-specific responses and also provide valuable insights to the pathogenesis of HIV-1 infection in vivo.
Priming (agriculture)
Ex vivo
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To study the relationship of Epstein-Barr virus (EBV) and T cell lymphoma.Sixty cases of T cell lymphomas were examined for the presence of EBV using in situ hybridization for EBV encoded RNA (EBERs).EBERs were detected in tumor cells in 37(69.8%) of 53 cases with peripheral T cell lymphoma, but in none of seven cases of precursor T lymphoblastic lymphoma. The total detected EBERs were 37(61.6%) in 60 cases of T cell lymphomas. By Revised European-American Lymphoma(REAL) classification, EBERs were detected in 2/2 angioimmuno-blastic T cell lymphoma,17/18 angiocentric lymphoma, 4/6 anaplastic large cell lymphoma and 14/27 peripheral T cell lymphoma, unspecified (51.9%). The frequency of EBERs among the extranodal peripheral T cell lymphoma was higher than the nodal (P less than 0.01) there was no significant correlation with the sex, age and clinical stage.This study indicated that high incidence of EBV was observed in peripheral T cell lymphoma, with predilection for angiocentric lymphoma and extranodal presentation.
Peripheral T-cell lymphoma
T-Cell Lymphoma
Anaplastic large-cell lymphoma
Lymphoblastic lymphoma
Large cell
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Abstract Against a subset of human cancers, vigorous tumor-specific CD8+ T cell responses can develop either spontaneously or upon allogeneic transplantation. However, the parameters that determine the induction of such pronounced anti-tumor immunity remain ill defined. To dissect the conditions required for the induction of high magnitude T cell responses, we have developed a murine model system in which tumor-specific T cell responses can be monitored directly ex vivo by MHC tetramer technology. In this model, tumor challenge of naive mice with Ag-bearing tumor cells results in a massive Ag-specific T cell response, followed by CD8+ T cell-dependent tumor rejection. We have subsequently used this model to assess the contribution of direct priming and cross-priming in the induction of tumor immunity in a well-defined system. Our results indicate that direct priming of T cells and Ag cross-priming are redundant mechanisms for the induction of tumor-specific T cell immunity. Moreover, T cell responses that arise as a consequence of Ag cross-presentation can occur in the absence of CD4+ T cell help and are remarkably robust.
Priming (agriculture)
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Objective To study the pathological features of T and NK cell lymphomas and the relative frequency of each type of these lymphomas.Methods 152 cases of T and NK cell lymphomas selected from archival tissues of lymphoid neoplasms diagnosed during the period of 1985～2005 were studied based on morphology,immunohistochemistry and in situ hybridization for Epstein-Barr virus(EBER) and correlated clinical findings,and reclassified according to new WHO classification(2001).Results The mean age of all the patients was 43 years old,ranged from 4 to 80 years old.The ratio of male to female was 3 to 1.There were 83 cases(54.6%) of extranodal lymphomas and 69 cases(45.4%) of nodal lymphomas.Ten types were identified in 152 cases of T and NK cell lymphoma.The most frequent type of the lymphoma was extranodal nasal NK/T cell lymphoma(52 cases,34.2%), followed by unspecified peripheral T cell lymphoma(31 cases,20.4%),precursor T lymphoblastic lymphoma(25 cases,16.4%) and anaplastic large cell lymphoma(21 cases,13.8%).Epstein-Barr virus was detected in 51 of 52 cases(98%) of extralnodal nasal NK/T cell lymphoma.Conclusions T and NK cell lymphomas show great morphological diversity.And each type has certain pathological features,which are the base of further classification.The most common type is extranodal nasal NK/T cell lymphoma.Frequency of T and NK cell lymphomas showed in this study in China is different from that in European and American countries,suggesting there may be different etiological factors.
T-Cell Lymphoma
Anaplastic large-cell lymphoma
Peripheral T-cell lymphoma
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