Utility and performance of cell blocks in cerebrospinal fluid cytology: Experience at two teaching hospitals
Hyeji YoonConstance V. ChenVimal KrishnanJill GrochowskiGioia IezzaPoonam VohraRonald BalassanianNancy Y. Greenland
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Abstract:
Cytology cell blocks (CBs) are not routinely made for cerebrospinal fluid (CSF) specimens. The goal of this study was to identify when CSF CB preparation improves diagnostic performance.Cite
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Seperti pada dewasa, teknik regional anestesi pada pediatrik kini makin popular digunakan oleh ahli anestesikarena keuntungannya. Namun demikian selalu ada risiko dan kemungkinan timbulnya komplikasi dari setiap tindakan yang dilakukan, termasuk tindakan anestesi regional pada pediatrik. Insidensi komplikasi anestesi regional pada pediatrik tidak banyak, dan kalaupun terjadi komplikasi adalah minor. Komplikasi bisa diakibatkan dari identifikasi ruang saraf, alat, obat, teknis tindakan anestesi regionalnya dan komplikasi lainnya.Walaupun tidak banyak kejadian komplikasi regional anestesi yang dilaporkan pada pediatrik, dan bukanlah komplikasi yang fatal, teknik regional anestesi pada pediatrik harus dilakukan dengan lebih hatihati, pertimbangan risiko dan keuntungannya untuk menghindari terjadinya komplikasi, terlebih karena kebanyakan komplikasi dapat dihindari dengan mempelajari teknik yang benar, menggunakan peralatan yang sesuai, dan sangat menerapkan prinsip keamanan pada pasien dengan baik.
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Objective To investigate the value of cerebrospinal fluid cytology in the diagnosis and treatment of central nervous system diseases.Methods Retrospective analysis of 213 cases of cerebrospinal fluid cytology test results and relevant clinical data of the central nervous system diseases in different changes of cerebrospinal fluid cytology;analysis of cell counts cytological changes of normal cases.Results Different central nervous system disease has its own characteristic of cerebrospinal fluid cytology;cell count can be normal in patients with abnormal cytology.Conclusions Cerebrospinal fluid cytology can be used as diagnosis and treatment of central nervous system disease monitoring important means of detection,is worthy of clinical application.
Key words:
Cerebrospinal fluid cytology; Routine test of cerebrospinal fluid; the central nervous system diseases
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Genentech is partnering with the German cancer company Affimed to develop immunotherapies for multiple kinds of solid and blood cancers. Affimed is developing therapies that engage natural killer cells of the innate immune system to help direct them to attack cancer cells. Genentech will pay Affimed $96 million up front and up to $5 billion more in potential payments.
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Objective:To discuss the value for earlier diagnosis and curative effect evaluation of tuberculosis meningitis(TBM)by detecting the cerebrospinal fluid(CSF)routine,biochemistry and cytology check.Methods:Dynamic Analysis of cerebrospinal fluid routine,biochemistry and cytology variation have been performed on 80 cases with TBM between prior-treatment and post-treatment.Results:There is a obviously rise performed in the cerebrospinal fluid for the pressure,biochemistry index singularity ratio and neutrophil proportion prior treatment,while a progressive decline was observed in post treatment with a significant difference.The typical TBM in forepart showed intermix cytology reaction which had most granulocytes.During the middle period of the treatment,granulocytes reduced,more over immune cells and active hyaline leukocytes increased.During the later period of the treatment,active lymphocytes reaction was the most obvious.Cerebrospinal fluid cytology was back to normal when TBM had been cured.Conclusion:The cerebrospinal fluid cytology check is a significant index in earlier diagnosis of TBM;Dynamic observation on cerebrospinal fluid cytology is helpful for earlier diagnosis of TBM.Furthermore the method has some value in judging the prognosis of the patients suffened TBM.
Tuberculous Meningitis
Cerebral Spinal Fluid
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Objective To explore the characteristics and clinical values of cerebrospinal fluid cytology in children with viral encephalitis.Methods Eighty children with viral encephalitis were enrolled as the case group and 40 children without central infectious disease were included as the control group.Abnormality rates of cerebrospinal fluid routine examination,cerebrospinal fluid biochemistry examination and cerebrospinal fluid cytology examination were compared between the two groups.Results The frequency of transformation lymphocyte was 87.5% and the abnormality detection rates were 41.2%,37.5%,and 78.8% for cerebrospinal fluid routine examination,cerebrospinal fluid biochemistry examination and cerebrospinal fluid cytology examination respectively in the case group(P0.01).Positive rates in the case group were 78.8% before treatment and 7.5% after treatment with significant difference(P0.01).Conclusion Cerebrospinal fluid cytology examination plays an important role in the diagnosis of viral encephalitis and in evaluation of treatment effects.
Viral encephalitis
Abnormality
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