CLINICAL OUTCOMES OF PATIENTS WITH ACUTE PANCREATITIS COMPLICATED WITH CONCOMITANT ACUTE MYOCARDIAL INFARCTION: AN ANALYSIS FROM A NATIONWIDE DATABASE
Shazib SagheerAditya IyerSyeda H. ZaidiOmar YacobPaul AndréAlex SchevchuckAbu Baker SheikhNajam Wasty
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Today up to 40% of Crohn's disease patients receive a concomitant therapy of TNF blockers in combination with thiopurines or methotrexate. Although data of prospective controlled trails are rare, some recently published studies indicate a more rapid onset of remission and increased mucosal healing following concomitant therapy in short term. However, data confirming the need or benefit of concomitant immunosuppressive therapy once remission has been reached remains unknown. Concomitant therapy lowers TNF-alpha induced immunogenicity, but the question of whether ATI formation also lowers the efficiency of TNF-alpha antagonists has not yet been answered to a level that would justify the use of concomitant immunosuppression. Knowing that immunosuppression increases the risk for opportunistic infections and lymphomas the potential risks and of concomitant therapy must be well balanced against the benefit. This article aims to interpret the available data on the efficiency, immunogenicity, and safety of concomitant therapy in patients under anti-TNF therapy.
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Objective To evaluate the efficacy of the perioperative management of concomitant cerebrovascular and/ar cardiovascular diseases in elderly patients with endometrial carcinoma.Methods The materials of 60 patients with endometrial carcinoma between 1980 and 2000 were retrospectively analyzed.The patients were divided into two groups according to the dividing point of concomitant cerebrovascular and/or cardiovascular diseases.Thirty six of them were identified to have concomitant cerebrovascular cerebr and/or cardiovascular diseases and the other 24 cases had no complicated diseases.Results Mean length of hospital stay of two groups was 29 days and 19 days,respectively(P 0.05 ),and intra operative and postoperative complications occurred in 14 cases and 6cases,respectively,(P0.05).Three and five year survival rates showed no significant difference.Conclusions The elderly patients with endometrial carcinoma and concomitant cerebrovascular and/or cardiovascular diseases can tolerate complicated gynecologic surgery in condition of controlling the perioperative concomitant diseases.
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Nephrology
Uremic Toxins
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ve To provide hand surgery with the regularity of concomitant relationship between the arteries and veins of the hand. Method Concomitant relationship between the arteries and veins of the hand were observed in 10 sides decicolor cast specimens and stuffing specimens perfused with hyperchlororinylacetic ether or emulsoid respectively. Results Compactly concomitant relationship was observed in the superficialand the deep arcus vasculosi, the palmal metacarpal vessels and the common palmal digital vessels. In the palm and the opisthenar, the superficial vessels were not concomitant or not compactly concomitant, so were the vessels of the maniphalanx. Conclusions The distribution regularity between the arteries and veins of the hand are showed as follows: Like a network, vessels are not concomitant in the superficial laminae of the hand. However, deeper to the partes profunda of the hand, more compactly concomitant relationship between the arteries and veins. The vessels of the maniphalanx are not concomitant or not compactly concomitant
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For a period of six years, concomitant disorders were registered at annual routine examinations of 226 residents of a central institution for mentally retarded. Only in six patients were no concomitant disorders found. 19.5% displayed concomitant disorders from one type of disease, 30.5% displayed two or more concomitant disorders from two types of disease, and as many as 47.3% displayed concomitant disorders from three or more types of disease. The residents examined showed particularly high occurrences of various deformities, mental disorders, and diseases of the nervous system, sense organs and musculo-skeletal system. The most frequent singular disorders were epilepsy, cerebral palsy and deformities of the back and foot.
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This retrospective study was designed to evaluate possible relationships between the number and types of concomitant medications administered to patients on the first day of therapy in phase I trials and demographic characteristics, outcome measures and toxicities. Concomitant medications received by 690 patients enrolled on 28 phase I trials between August 1985 and January 1996 were grouped into 31 categories based on the American Hospital Formulary Service 1993. These patients received 1650 cycles of treatment with investigational agents (median 2 cycles per patient). Median duration on-study was 49 days (range 1–776 days). Clinical response rate (complete, partial, minor) was 3.8% Only three toxic deaths occurred (0.4%). Nearly and patients (90.9%) received at least one concomitant medication on the first day of therapy. The number of concomitant medications directly correlated with poor performance status (rsp=0.27, p<0.0001) and indirectly with duration on-study (rsp=-0.18, p<0.0001). The dose of the investigational agent administered during the first course of therapy was not related to concomitant medications on the first day of therapy. Most importantly, no relationships were observed between concomitant medications and either toxicities or clinical response to therapy. We conclude that patients who are receiving concomitant medications should not systematically be excluded from phase I studies, [r 1999 Lippincott Williams & Willkins.]
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Formulary
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To describe the clinical characteristics in classical trigeminal neuralgia (TN) with concomitant persistent pain and to investigate whether TN with concomitant persistent pain represents a distinct phenotype.There has been much debate about the possible pathophysiological and clinical importance of concomitant persistent pain in TN. This has led to subgrouping of TN into forms with and without concomitant persistent pain in the recent 3rd International Classification of Headache Disorders beta classification.In this cross-sectional study, data on the clinical characteristics were systematically and prospectively collected from consecutive TN patients.A total of 158 consecutive TN patients were included. Concomitant persistent pain was present in 78 patients (49%). The average intensity of concomitant persistent pain was 4.6 (verbal numerical rating scale). The concomitant persistent pain was present at onset or early in the disease course. Patients with concomitant persistent pain were on average 6.2 (P = .008) years younger at onset, but the 2 groups had the same duration of disease (P = .174). There was a preponderance of women in TN with (P < .001) but not in TN without concomitant persistent pain (P = .820). Right-sided pain was more prevalent than left-sided in TN without (P = .007) but not in TN with concomitant persistent pain (P = .907). TN with concomitant persistent pain more frequently had sensory abnormalities (P < .001) and less frequently responded to sodium channel blockers (P = .001). There were no significant differences in other clinical characteristics.Concomitant persistent pain is very prevalent in TN and is not a consequence of paroxysmal pain. Findings support that the 3rd International Classification of Headache Disorders beta division of TN with and without concomitant persistent pain is clinically and scientifically important.
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Trigeminal Nerve
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