Novel evidence that the ABO blood group shapes erythropoiesis and results in higher hematocrit for blood group B carriers
Romy Kronstein‐WiedemannSarah BlecherMadeleine TeichertLaura S. SchmidtJessica ThielMarkus MüllerJörn LausenRichard SchäferTorsten Tonn
2
Citation
59
Reference
10
Related Paper
Citation Trend
Abstract:
The ABO blood group (BG) system is of great importance for blood transfusion and organ transplantation. Since the same transcription factors (TFs) and microRNAs (miRNAs) govern the expression of ABO BG antigens and regulate erythropoiesis, we hypothesized functional connections between both processes. We found significantly higher hemoglobin and hematocrit values in BG B blood donors compared to BG A. Furthermore, we observed that erythropoiesis in BG B hematopoietic stem/progenitor cells (HSPCs) was accelerated compared to BG A HSPCs. Specifically, BG B HSPCs yielded more lineage-specific progenitors in a shorter time (B: 31.3 ± 2.2% vs. A: 22.5 ± 3.0%). Moreover, non-BG A individuals exhibited more terminally differentiated RBCs with higher enucleation rates containing more hemoglobin compared to BG A. Additionally, we detected increased levels of miRNA-215-5p and -182-5p and decreased expression of their target TFs RUNX1 and HES-1 mRNAs in erythroid BG B precursor cells compared to BG A. This highlights the important roles of these factors for the disappearance of differentiation-specific glycan antigens and the appearance of cancer-specific glycan antigens. Our work contributes to a deeper understanding of erythropoiesis gene regulatory networks and identifies its interference with BG-specific gene expression regulations particularly in diseases, where ABO BGs determine treatment susceptibility and disease progression.Keywords:
Hematology
Group A
Blood group antigens
Blood group antigens
Cite
Citations (0)
The phenomenon of accommodation in recipients of blood group ABO incompatible kidney transplantation (iKTx), in which grafts survive despite the presence of blood group A or B antigen in the graft and the presence of corresponding antibodies in the recipient’s blood, is not uncommon. α1,3-N-Acetylgalactosaminyltransferase and α1,3galactosyltransferase associated with the synthesis of blood group A and B antigen (A and B enzymes), respectively, were measured by a highly specific enzyme-linked immunosorbent assay in the sera and transplanted tissues of patients who underwent an ABO iKTx. Allogeneic A and B enzymes were present in the sera and tissues as well as A and B antigens in the tissues for a long period, which hitherto have never been seen in recipients prior to an iKTx. However, activities of these enzymes in the sera after an iKTx decreased in patients who experienced a serious acute antibody-mediated rejection and disappeared in patients who had an unrepairable rejection, leading to graft loss without establishment of accommodation. Our observations on the presence of allogeneic A and B enzymes in the recipients’ sera should have implications in decision making for a successful iKTx.
Group A
Group B
Blood type (non-human)
Cite
Citations (7)
The distribution of ABO blood in two groups of people with Australia antigen was studied (121 blood donors and 128 patients) and in 3 ,091 controls was investigated. There was a significant excess of A in comparison with o when the two groups were combined, and when the two groups were tested for (A + B): (AB +O) individually and together, both were found to be statistically significant. The results are discussed.
Blood group antigens
Cite
Citations (4)
The absorption-elution method allows the determination of the blood group properties of the ABO-System from human teeth. The results of own investigations carried out on a larger number of specimens are reported. The significance of the determination of the blood group antigens in teeth for the forensic stomatology is emphasized.
Blood group antigens
Human blood
Blood grouping
Blood Stains
Cite
Citations (2)
Blood group antigens are surface markers on the red blood cell membrane. Biochemical analysis of blood group antigens has shown that these antigens divide into two types of proteins and carbohydrates attached to lipids or proteins. Protein determinants are directly coded on blood group genes, while carbohydrate determinants are controlled through the expression of glycosyltransferase enzymes. For the past ten years, considerable information has been gained from molecular studies of many blood group systems, thereby clarifying several aspects of these genes, genetic backgrounds of variants, and molecular evolution. Additionally, it has become possible to genotype blood groups and to genetically engineer the expression of protein antigens and the activity and specificity of enzymes. ABO system on the carbohydrate and Rh system on the protein are the most important systems in transfusion medicine. In this paper, we will review recent progress in the field of blood grouping; mainly ABO and Rh.
Blood group antigens
Blood type (non-human)
Cite
Citations (1)
Blood group antigens
Cite
Citations (9)
Background: Among more than 30 blood group systems, nine of them namely ABO, Rh, Kell, Kidd, Duffy, MNS, P, Lewis and Lutheran are considered to be clinically significant. The distributions of these blood groups are different between populations across the world. Studies about the frequency of blood groups in Kurdish ethnicity are very limited in the literature.
Objectives: to explore the distribution of red cell antigens and phenotypes of various blood groups among Kurdish population using different systems.
Materials and Methods: five thousand blood donors attending the central blood bank of Sulaymaniyah province were randomly selected and tested for ABO and Rh antigens (D, C, c, E, & e) by using tube method. 500 donors were randomly selected and further analyzed using other blood group systems.
Results: In the ABO system, the most common phenotype was O (37%), followed by A (32.6%), B (22.8%) and AB (7.6%). Among the Rh blood group antigens, e was the most common (95.2%) followed by D (91.3%), C (74.8%), c (69.4%), and E (30.6%) with DCe/DCe(R1R1) and dce/dce(rr) being the most common phenotypes among Rh-D+ve and Rh-D-ve groups, respectively. The most common phenotypes for other blood systems were as follow; Kell(K-k+,94%), Kidd(jk a+b+,44.5%), Duffy(fy a+b+,45%), Lutheran(Lu a-b+,92%), Lewis(Le a-b+,54.5%), P(P1,76%), MNS(M+N+S-s+,40%)
Conclusion: the various red cell antigens recorded by different blood grouping systems in this study was intermediate between the European and Asian countries with some specificity to the Kurds population reflecting the distinct geographical area and preserved ethnic background of the Kurds in the region.
Blood group antigens
H antigen
Blood type (non-human)
Red Cell
Cite
Citations (8)
Blood group antigens
Hemagglutination tests
Cite
Citations (3)
Blood group antigens
Cite
Citations (1)
Most blood groups are organised into blood group systems. Most blood group antigens are proteins or glycoproteins, with the blood group specificity determined primarily by the amino acid sequence, and most of the blood group polymorphisms result from single amino acid substitutions, though there are many exceptions. ABO is often referred to as a histo-blood group system because, in addition to being expressed on red cells, ABO antigens are present on most tissues and in soluble form in secretions. Rh is the most complex of the blood group systems, with many specificities. The most important of these is D (RH1). Of the remaining blood group systems, the most important clinically are Kell, Duffy, Kidd and MNS. The functions of several red cell membrane protein structures bearing blood group antigenic determinants are known, or can be deduced from their structure.
Blood group antigens
Isoantigens
Blood type (non-human)
Cite
Citations (4)