Research Hotspots and Frontiers of Transcranial Direct Current Stimulation in Stroke: A Bibliometric Analysis
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Background: Over the past decade, many studies in the field of transcranial direct current stimulation (tDCS) in stroke have been published in scholarly journals. However, a scientometric analysis focusing on tDCS after stroke is still missing. The purpose of this study is to deliver a bibliometric analysis to investigate the global hotspots and frontiers in the domain of tDCS in stroke from 2012 to 2021. Methods: Articles and reviews related to tDCS in stroke were retrieved and obtained from the Web of Science core collection database from 2012 to 2021. Data visualization and analysis were conducted by using CiteSpace, VOSviewer, and Microsoft Excel 2019. Results: Finally, 371 publications were included in the scientometric analysis, including 288 articles and 83 reviews. The results showed that the number of publications per year increased from 15 to 68 in the last 10 years. Neurosciences was the main research hotspot category (n = 201). Frontiers in Human Neuroscience was the most published journal with 14 papers. The most productive author, institution, and country were Fregni F (n = 13), the League of European Research Universities (n = 37), and the United States of America (n = 98), respectively. A burstness analysis of keywords and the literature indicated that current studies in the field of tDCS in stroke focused on poststroke aphasia, tDCS combined with robotic therapy, and anatomical parameters. Conclusion: The research of tDCS in stroke is predicted to remain a research hotspot in the future. We recommend investigating the curative effect of other different tDCS closed-loop rehabilitation methods for different stroke dysfunctions. In conclusion, this bibliometric study presented the hotspots and trends of tDCS in stroke over the last decade, which may help researchers manage their further studies.Keywords:
Transcranial Direct Current Stimulation
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Stroke
Brain stimulation
Background: Cortical plasticity underlies the brain's ability to compensate and adapt after neurological and musculoskeletal injury. However, increasing evidence demonstrates that plasticity can also be maladaptive, contributing to functional impairment in a variety of conditions. Transcranial direct current stimulation (tDCS) is an emerging brain stimulation technique with the potential to alter cortical plasticity and prime the brain to enhance learning. If the potential of this technique can be harnessed, tDCS may provide a novel therapeutic approach in physiotherapy practice. Objectives: This review aims to provide an overview of the mechanisms, stimulation parameters and clinical applications of tDCS. Major findings: tDCS is an emerging and novel technique. Evidence at this early stage is promising with reductions in pain scores and improvements in motor function noted across a range of conditions. However, further research is needed before clinical efficacy and safety can be determined. Conclusions: tDCS is a powerful, non-invasive brain stimulation technique with the potential to improve outcomes in neurological and musculoskeletal conditions. Further research is needed using large sample sizes, long-term follow-up and a range of patient populations before the technique is available for clinical use. However, tDCS may be useful as a standalone therapy or as an adjunct to other physiotherapy treatments in the future.
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Transcranial direct current stimulation (tDCS) is non-invasive brain stimulation technique increasingly used for modulation of central nervous system excitability in humans. The use of non-invasive brain stimulation has significant advantages, such as not involving surgical procedures and having relatively mild adverse effects. In recent years there has been an exponential rise in the number of studies employing tDCS as a means of gaining an improvement on motor and cognitive function in patients with neurological diseases. In the present review, we will first introduce a brief background on the basic principles of tDCS. We also summarize recent studies with tDCS that aimed at enhancing behavioral outcome or disease-specific symptoms in patients suffering from stroke, movement disorders, Alzheimer disease, and epilepsy. Although outcomes of tDCS trials include some conflicting results, the evidence supports that tDCS might have a therapeutic value in different neurological conditions. Key Words: Brain, Excitability, Modulation, Transcranial direct current stimulation
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Transcranial direct current stimulation (tDCS) is a popular brain stimulation method that is used to modulate cortical excitability, producing facilitatory or inhibitory effects upon a variety of behaviors. There is, however, a current lack of consensus between studies, with many results suggesting that polarity-specific effects are difficult to obtain. This article explores some of these differences and highlights the experimental parameters that may underlie their occurrence. We provide a general, practical snapshot of tDCS methodology, including what it is used for, how to use it, and considerations for designing an effective and safe experiment. Our aim is to equip researchers who are new to tDCS with the essential knowledge so that they can make informed and well-rounded decisions when designing and running successful experiments. By summarizing the varied approaches, stimulation parameters, and outcomes, this article should help inform future tDCS research in a variety of fields.
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Abstract Purpose Identifying the effective treatments for diseases has been a critical issue in daily clinical practice, especially for Alzheimer’s dementia (AD). Abundant evidence showed that non-invasive brain stimulation (NIBS) has the potential to slow or reverse cognitive function decline. Among them, the transcranial Direct Current Stimulation (tDCS) would be relatively safe for patients with AD. The purpose of this study was to review the relevant articles to explore the mechanism and effect of tDCS and other NIBS in AD treatment. Methods All the reported works were retrieved from two databases (i.e., PubMed and Google Scholar) by using the keywords “NIBS” and “AD”. The mechanisms and effects of different NIBS applied in AD, including transcranial ultrasound stimulation (TUS), transcranial near-infrared (tNIR) light therapy, transcranial magnetic stimulation (TMS), and transcranial electric stimulation (TES) were reviewed. Results The positive effects of TUS and tNIR on AD were supported by a few small samples and uncontrolled pilot studies. tDCS and repetitive TMS have been often used in an attempt to improve the cognition in people with brain disorders. Both the tDCS and TMS have benefits in AD by introducing long-term potentiation like change in synaptic strength. The reports showed that tDCS could be more safe, convenient, affordable, and well-tolerated method among all applications for AD treatment. Conclusion In this review, it was shown that all the NIBS have positive effects on AD treatment. But, however, tDCS showed the great potential in improving the cognition of AD.
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Enhancing creative problem solving with neuromodulatory approaches is gaining increased interest. However, inconsistent findings of the success in such approaches emphasize the need for a comprehensive overview of the effect of using non-invasive brain stimulation (NIBS) on creative thinking. The current meta-analysis aimed to investigate whether creative thinking can be improved by NIBS, especially through transcranial direct current stimulation (tDCS). 34 studies with 97 effect sizes (N = 1574 participants, 84 in excitatory stimulation, and 13 in inhibitory stimulation) were included. Our analyses showed that excitatory NIBS had a small but positive effect on creative performance for both divergent and convergent thinking, but inhibitory NIBS showed non significant effects. For tDCS studies, there was an excitatory effect via anodal tDCS over the left dorsal prefrontal cortex, and an inhibitory effect via cathodal tDCS over the left inferior frontal gyrus on creative thinking. Our study suggests brain stimulation may hold the key to unleash creativity and also highlights issues to be addressed in future research.
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Experimental studies suggest that the non-invasive brain stimulation technique transcranial direct current stimulation (tDCS) may potentiate rehabilitation following stroke and lead to improved motor function. This effect is believed to be due to correction of imbalanced interhemispheric inhibition. The results of recent trials are promising, but optimal stimulation paradigms are yet to be determined and further investigations are required, before tDCS can be recommended for stroke rehabilitation.
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Non-invasive brain stimulation with weak direct currents (transcranial direct current stimulation (tDCS)) has emerged as one of the major tools to induce neuroplastic cortical excitability alterations in humans since its (re-) introduction to the ars
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Transcranial direct current stimulation (TDCS) is an emerging technique of noninvasive brain stimulation that has been found useful in examining cortical function in healthy subjects and in facilitating treatments of various neurologic disorders. A better understanding of adaptive and maladaptive poststroke neuroplasticity and its modulation through noninvasive brain stimulation has opened up experimental treatment options using TDCS for patients recovering from stroke. We review the role of TDCS as a facilitator of stroke recovery, the different modes of TDCS, and the potential mechanisms underlying the neural effects of TDCS.
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AbstractPurpose Aphasia is an acquired language impairment that commonly results from stroke. Non-invasive brain stimulation (NIBS) might accelerate aphasia recovery trajectories and has seen mounting popularity in recent aphasia rehabilitation research. The present review aimed to: (1) summarise all existing literature on NIBS as a post-stroke aphasia treatment; and (2) provide recommendations for future NIBS-aphasia research.Materials and methods Databases for published and grey literature were searched using scoping review methodology. 278 journal articles, conference abstracts/posters, and books, and 38 items of grey literature, were included for analysis.Results Quantitative analysis revealed that ipsilesional anodal transcranial direct current stimulation and contralesional 1-Hz repetitive transcranial magnetic stimulation were the most widely used forms of NIBS, while qualitative analysis identified four key themes including: the roles of the hemispheres in aphasia recovery and their relationship with NIBS; heterogeneity of individuals but homogeneity of subpopulations; individualisation of stimulation parameters; and much remains under-explored in the NIBS-aphasia literature.Conclusions Taken together, these results highlighted systemic challenges across the field such as small sample sizes, inter-individual variability, lack of protocol optimisation/standardisation, and inadequate focus on aphasiology. Four key recommendations are outlined herein to guide future research and refine NIBS methods for post-stroke aphasia treatment.IMPLICATIONS FOR REHABILITATIONA comprehensive review of non-invasive brain stimulation (NIBS) post-stroke aphasia literature, including all study designs, was required.Review of this literature revealed that anodal transcranial direct current stimulation is the mostly commonly used type of NIBS in aphasia treatment research.Systemic challenges across the field hinder prospective translation of NIBS into aphasia practice.Aphasia rehabilitation professionals should note that further research is required before NIBS is suitable for translation into clinical practice.Keywords: Aphasiastrokenon-invasive brain stimulationtranscranial direct current stimulationtranscranial magnetic stimulationrepetitive transcranial magnetic stimulationrehabilitation Disclosure statementBH has a clinical partnership with Fourier Intelligence and a paid consultancy role with Recovery VR.Additional informationFundingThis work was supported by the Australian Research Council Future Fellowships Grant (grant number: FT210100694) and the Australian Government Research Training Program Scholarship.
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