logo
    Does the primary treatment sequence affect post‐relapse survival in recurrent epithelial ovarian cancer? A real‐world multicentre retrospective study
    BJOG An International Journal of Obstetrics & Gynaecology (2022)
    Xingyu LiuYingjun ZhaoXiaofei JiaoYang YuRuyuan LiShaoqing ZengJianhua ChiGuanchen MaYabing HuoMing LiZikun PengJiahao LiuQi ZhouDongling ZouLi WangQingshui LiJing WangShuzhong YaoYouguo ChenDing MaTing HuQinglei Gao
    2
    Citation
    39
    Reference
    10
    Related Paper
    Citation Trend
    Abstract:
    Abstract Objective To explore the impact of the primary treatment sequence (primary debulking surgery, PDS, versus neoadjuvant chemotherapy and interval debulking surgery, NACT‐IDS) on post‐relapse survival (PRS) and recurrence characteristics of recurrent epithelial ovarian cancer (REOC). Design Real‐world retrospective study. Setting Tertiary hospitals in China. Population A total of 853 patients with REOC at International Federation of Gynaecology and Obstetrics stages IIIC–IV from September 2007 to June 2020. Overall, 377 and 476 patients received NACT‐IDS and PDS, respectively. Methods Propensity score‐based inverse probability of treatment weighting (IPTW) was performed to balance the between‐group differences. Main Outcome Measures Clinicopathological factors related to PRS. Results The overall median PRS was 29.3 months (95% CI 27.0–31.5 months). Multivariate analysis before and after IPTW adjustment showed that NACT‐IDS and residual R1/R2 disease were independent risk factors for PRS ( p < 0.05). Patients with diffuse carcinomatosis and platinum‐free interval (PFI) ≤ 12 months had a significantly worse PRS ( p < 0.001). Logistic regression analysis revealed that NACT‐IDS was an independent risk factor for diffuse carcinomatosis (OR 1.36, 95% CI 1.01–1.82, p = 0.040) and PFI ≤ 12 months (OR 1.59, 95% CI 1.08–2.35, p = 0.019). In IPTW analysis, NACT‐IDS was still significantly associated with diffuse carcinomatosis (OR 1.29, 95% CI 1.05–1.58, p = 0.015) and PFI ≤ 12 months (OR 1.90, 95% CI 1.52–2.38, p < 0.001). Conclusions The primary treatment sequence may affect the PRS of patients with REOC by altering the recurrence pattern and PFI duration.
    Keywords:
    Affect
    Sequence (biology)
    Primary (astronomy)
    Topics:
    Ovarian cancer diagnosis and treatment
    Endometrial and Cervical Cancer Treatments
    PARP inhibition in cancer therapy
    Efficient One-Step Conversion of Primary Aliphatic Amines into Primary Alcohols: Application to a Model Study for the Total Synthesis of (±)-Scopadulin
    Organic Letters (2000)
    S. M. Abdur RahmanHiroaki OhnoNaoyoshi MaezakiC. IWATATetsuaki Tanaka
    [reaction: see text] Treatment of primary aliphatic amines with KOH in diethylene glycol at 210 degrees C gives primary alcohols directly in good yields. A synthetic application to a model study of (+/-)-scopadulin is also described.
    Primary (astronomy)
    Diethylene glycol
    Primary alcohol
    Citations (28)
    Reaction of 3,3,4,4-tetracyanopyrrolidines with primary alcohols and amines
    Chemistry of Heterocyclic Compounds (1991)
    О. Е. НасакинА. Н. ЛыщиковP. M. LukinA. Kh. BulaiВ. А. Тафеенко
    Primary (astronomy)
    Base (topology)
    Cyclic amines
    Citations (1)
    Oxidative Conversion of Primary Alcohols, and Primary, Secondary, and Tertiary Amines into the Corresponding Nitriles with 1,3-Diiodo-5,5-dimethylhydantoin in Aqueous NH3
    Synlett (2007)
    Hideo TogoShinpei Iida
    Various primary alcohols, and primary, secondary, and tertiary amines were oxidatively and efficiently converted into the corresponding nitriles in good yields, by 1,3-diiodo-5,5-dimethylhydantoin (DIH) in aqueous ammonia (NH3) at 60 °C.
    Primary (astronomy)
    Tertiary alcohols
    Citations (14)
    Hereditary Issues In Ovarian Cancer
    Humana Press eBooks (2007)
    Christina ChuStephen C. Rubin
    Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer deaths, although it accounts for only about one-quarter of all gynecological malignancies (1, 2). A woman's lifetime risk of ovarian cancer is about 1 in 70. In the year 2004, the American Cancer Society estimated that 25,580 women would be diagnosed with ovarian cancer in the United States, and that 16,090 would die of this disease (3).
    Quarter (Canadian coin)
    Citations (0)
    THE IMPACT OF CHARLSON’S COMORBIDITY INDEX IN OVERALL SURVIVAL FOR ADVANCED EPITHELIAL OVARIAN CANCER
    Glauco BaiocchiRafael Leite NunesHenrique MantoanBruna Tirapelli GonçalvesCarlos Chaves Faloppa
    Charlson comorbidity index
    Citations (0)
    N-Arylation of Primary and Secondary Aliphatic Amines on Solid Supports
    Journal of Combinatorial Chemistry (2002)
    Andrew P. CombsSeifu TadesseMaria RafalskiTasir S. HaquePatrick Y. S. Lam
    A general and mild method for the N-arylation of primary and secondary aliphatic amines is reported. Copper acetate, triethylamine mediated C/N cross-coupling reaction of arylboronic acids at room temperature to solid-supported primary and secondary amines gave good to excellent yields of the desired N-arylated products.
    Primary (astronomy)
    Triethylamine
    Citations (45)
    Efficient conversion of primary and secondary alcohols to primary amines
    Tetrahedron Letters (2007)
    Weilin SunJeffrey C. Pelletier
    Primary (astronomy)
    Primary alcohol
    Citations (12)
    ChemInform Abstract: PYRYLIUM‐MEDIATED CONVERSION OF PRIMARY ALKYL PRIMARY AMINES INTO OLEFINS VIA TETRAHYDROBENZOACRIDINIUMS: A MILD ALTERNATIVE TO THE HOFMANN ELIMINATION
    Chemischer Informationsdienst (1983)
    A. R. KATRITZKYA. M. EL‐MOWAFY
    Abstract Aus den Tetrahydro‐dibenzoxanthylium‐Salzen (I) erhält man mit den Aminen (II) die entsprechenden Benzacridinium‐Salze (III), die thermisch zu den Olefinen (IV) gespalten werden.
    Primary (astronomy)
    Citations (0)
    REACTIONS OF DICHLOROACETYLENE WITH PRIMARY ALIPHATIC AMINES
    Bulletin des Sociétés Chimiques Belges (1995)
    Jan PielichowskiPiotr Czub
    Abstract Primary aliphatic amines are good nucleophilic reagents which easily react with dichloroacetylene (DCA). The reactions of DCA with primary aliphatic amines have been studied and a mechanism of these reactions has been proposed and discussed.
    Primary (astronomy)
    Citations (1)
    The N‐Substitution of Aliphatic Primary Amines via 1‐[(Alkylamino)methyl]benzotriazoles: Preparation of Secondary Amines
    Chemische Berichte (1990)
    Alan R. KatritzkyG. NOBLEBogusław PilarskiPhilip A. Harris
    Abstract A new method has been developed for the selective conversion of primary aliphatic amines into unsymmetrical secondary amines by Grignard reaction of 1‐[(alkylamino)methyl]‐benzotriazoles 1 . This method employs simple procedure and mild conditions, and is specific in that only monoalkylation of the primary amines results.
    Primary (astronomy)
    Substitution (logic)
    Citations (19)