Influence of donor age and comorbidities on transduced human adipose-derived stem cell in vitro osteogenic potential
Kevin CollonJennifer A. BellMatthew C. GalloStephanie W. ChangSofia BougioukliOsamu SugiyamaJade TasseyRoger P. HollisNathanael D. HeckmannDaniel A. OakesDonald B. LongjohnDenis EvseenkoDonald B. KohnJay R. Lieberman
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Stem Cell Therapy
Stem cells are generally defined as cells that have the capacity to self-renewal and differentiate to specialize cell. There are two kinds of stem cell, embryonic stem cell and adult stem cells. Stem cell therapy has been used to treat diseases including Parkinson's and Alzheimer's diseases, spinal cord injury, stroke, burns, heart diseases, diabetes, osteoarthritis, and rheumatoid arthritis. Stem cells were found in dental pulp, periodontal ligament, and alveolar bone marrow. Because of their potential in medical therapy, stem cells were used to regenerate lost or damage teeth and periodontal structures. This article discusses the potential application of stem cells for dental field.
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During development, stem cells generate all of the differentiated cells that populate our tissues and organs. Stem cells are also responsible for tissue turnover and repair in adults, and as such, they hold tremendous promise for regenerative therapy. Aging, however, impairs the function of stem cells and is thus a significant roadblock to using stem cells for therapy. Paradoxically, the patients who would benefit the most from regenerative therapies are usually advanced in age. The use of stem cells from young donors or the rejuvenation of aged patient-derived stem cells may represent part of a solution. Nonetheless, the transplantation success of young or rejuvenated stem cells in aged patients is still problematic, since stem cell function is greatly influenced by extrinsic factors that become unsupportive with age. This article briefly reviews how aging impairs stem cell function, and how this has an impact on the use of stem cells for therapy.
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Introduction : Stem cells are cell that can differentiate into any cells. Stem cells can be used
for therapy. Initially stem cells only used as therapy for diseases, in newest research, stem cells
also used as anti aging therapy.
Methods : Stem cell was taken from liposuction fat, processed with centrifugation, incubation,
and washed with collagenase to gain the stem cell. Stem cell given by intravenous injection for
anti aging therapy.
Result : 2 weeks after stem cell therapy, the face looks brightened, reduced wrinkles, better
skin texture, stamina improved, and improvement of hernia nucleus pulpous in three months.
Discussion : Stem cell therapy basically works in injury places. We used intravenous injection
delivery methods so the stem cell works all over the body to heal the injury places, including
degradated collagen caused by aging. Injection of stem cell significantly increased collagen
synthesis.
Conclusion: Stem cell can be used as anti aging therapy
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Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. Bone marrow transplant is the most widely used stem-cell therapy, but some therapies derived from umbilical cord blood are also in use. Research is underway to develop various sources for stem cells, as well as to apply stem-cell treatments for neurodegenerative diseases and conditions such as diabetes and heart disease, among others. Stem-cell therapy has become controversial following developments such as the ability of scientists to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. This controversy is often related to abortion politics and to human cloning. Additionally, efforts to market treatments based on transplant of stored umbilical cord blood have been controversial. Stem cells are being studied for a number of reasons. The molecules and exosomes released from stem cells are also being studied in an effort to make medications. In addition to the functions of the cells themselves, paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be another mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases.
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Introduction : Stem cells are cell that can differentiate into any cells. Stem cells can be used
for therapy. Initially stem cells only used as therapy for diseases, in newest research, stem cells
also used as anti aging therapy.
Methods : Stem cell was taken from liposuction fat, processed with centrifugation, incubation,
and washed with collagenase to gain the stem cell. Stem cell given by intravenous injection for
anti aging therapy.
Result : 2 weeks after stem cell therapy, the face looks brightened, reduced wrinkles, better
skin texture, stamina improved, and improvement of the Melasma. Fat transfer with stem cell
therapy more available than usual technique
Discussion : Stem cell therapy basically works in injury places. We used intravenous injection
delivery methods so the stem cell works all over the body to heal the injury places, including
degradated collagen caused by aging. Injection of stem cell significantly increased collagen
synthesis and long life of fat transfer.
Conclusion: Stem cell can be used for aesthetic therapy
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Autologous stem cell-based therapy offers many advantages over other nonsurgical treatments of peripheral arterial disease. Transplant stem cells are a renewable source of multiple cytokines and growth factors. Autologous adult stem cells are not rejected and do not form teratomas. Early preliminary results indicate that adult stem cell therapy is safe and effective in patients with critical limb ischemia.
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Stem cell therapy provides exciting possibilities for the treatment of acute myocardial infarction.The mechanisms behind the way in which stem cells improve cardiac function are still unclear.Yet,there are many methods to induce stem cells to express grafted cells.This article introduces current methods of using stem cells and the possible mechanisms for stem cells to treat myocardial infarction.
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