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    Elevated spinal fluid pressure as only sign of cerebral venous thrombosis.
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    Patients requiring neurosurgical intervention are known to be at increased risk for deep vein thrombosis (DVT) and attendant morbidity and mortality. Pulmonary embolism (PE) is the most catastrophic sequela of DVT and is the direct cause of death in 16% of all in-hospital mortalities. Protocols for DVT screening and early detection, as well as treatment paradigms to prevent PE in the acute postoperative period, are needed in neurosurgery. The authors analyzed the effectiveness of weekly lower-extremity venous duplex ultrasonography (LEVDU) in patients requiring surgical intervention for cranial or spinal pathology for detection of DVT and prevention of PE.Data obtained in 1277 consecutive patients admitted to a major tertiary care center requiring neurosurgical intervention were retrospectively reviewed. All patients underwent admission (within 1 week of neurosurgical intervention) LEVDU as well as weekly LEVDU surveillance if the initial study was normal. Additional LEVDU was ordered in any patient in whom DVT was suspected on daily clinical physical examination or in patients in whom chest CT angiography confirmed a pulmonary embolus. An electronic database was created and statistical analyses performed.The overall incidence of acute DVT was 2.8% (36 patients). Of these cases of DVT, a statistically significant greater number (86%) were discovered on admission (within 1-7 days after admission) screening LEVDU (p < 0.05), whereas fewer were documented 8-14 days after admission (2.8%) or after 14 days (11.2%) postadmission. Additionally, for acute DVT detection in the present population, there were no underlying statistically significant risk factors regarding baseline physical examination, age, ambulatory status, or type of surgery. The overall incidence of acute symptomatic PE was 0.3% and the mortality rate was 0%.Performed within 1 week of admission in patients who will undergo neurosurgical intervention, LEVDU is effective in screening for acute DVT and initiating treatment to prevent PE, thereby decreasing the overall mortality rate. Routine LEVDU beyond this time point may not be needed to detect DVT and prevent PE unless a change in the patient's physical examination status is detected.
    Sequela
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    Thrombosis of the deep cerebral venous system is a rare entity with a very poor prognosis. We report two patients with thrombosis of the internal cerebral veins and vein of Galen who responded to local urokinase. We review all 49 cases of deep cerebral venous thrombosis in the English literature. The mortality rate for patients treated with either IV heparin or local thrombolytics was 13% compared with 48% in untreated patients (p = 0.037). Based on this retrospective review of the literature and our two cases, we support the use of heparin or local thrombolytics in individual cases of deep cerebral venous thrombosis.
    Intracranial Thrombosis
    Cerebral veins
    Citations (72)
    An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
    Intracranial Thrombosis
    Cerebral Spinal Fluid
    Venous pressure
    Citations (0)
    Cerebral venous thrombosis represents less than 5% of all strokes. Isolated cerebral deep venous thrombosis is very rare. We present a case of isolated thrombosis of the internal cerebral veins and the vein of Galen diagnosed on CT and MRI, and we review the literature. We emphasize the pathognomonic signs on CT and MRI necessary for an early diagnosis obviating conventional angiography. Early diagnosis and treatment may avoid potentially devastating consequences.
    Pathognomonic
    Intracranial Thrombosis
    Cerebral veins
    Magnetic resonance angiography
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    Cerebral venous thrombosis is an uncommon disorder in the general population. Venous and arterial thrombosis is a rare but well-recognized extraintestinal complication of ulcerative colitis. Venous thromboembolic events commonly involve deep peripheral veins, and cerebral venous thrombosis is less common. We report a case of cerebral vein thrombosis associated with ulcerative colitis managed successfully with anticoagulant therapy.
    Cerebral veins
    Intracranial Thrombosis
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    Radiologic Diagnosis of Cerebral Venous Thrombosis: Pictorial ReviewColin S. Poon1 2, Ja-Kwei Chang1, Amar Swarnkar1, Michele H. Johnson2 and John Wasenko1Audio Available | Share
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    With its highly variable clinical presentation, the diagnosis of cerebral venous sinus thrombosis (SVT) and deep venous thrombosis (DVT) is challenging. The aims of this study was to determine the radiographic findings detected by magnetic resonance imaging in Roi-Et hospital of cerebral venous thrombosis. A retrospective review of patient who had magnetic resonance imaging performed for cerebral venous thrombosis detection, between August 2013 to August 2015 by using PACS to access imaging features, location, and extension. Sensitivity of non contrast CT scan and contrast enhanced CT in determine cerebral venous thrombosis were calculated. Twenty patients with cerebral veins thrombosis were reviewed. The most common radiographic findings was intracerebral hemorrhage, and cerebral infarction, eleven patients (55%). Twelve patients (60%) had had subacute clot. The most common location of cerebral venous thrombosis is superior sagittal sinus, fourteen patients (70%) and cortical vein, ten patients (50%). Most of them had multiple location of thrombosis. Sensitivity of non contrast CT to identified cerebral venous thrombosis (cord sign or attenuated vein sign) was 92.8% and sensitivity of contrast enhanced CT was 100%. On MRI, the sequence that had highest sensitivity to detected cerebral venous thrombosis was contrast enhanced MRV, 19 patents (95%) and gradient images, 16 patents (80%). Most common symptoms of cerebral venous thrombosis patient was headache, twelve patients (60%) and weakness, eleven patients (55%) presented with weakness. In conclusion the most common radiographic finding of cerebral venous thrombosis was cerebral infarction and hemorrhage, most common location of the thrombosis was superior sagittal sinus in subacute stage with high detection rate from CT with and without contrast Keywords: Cerebral venous thrombosis, MRI, CT
    Intracranial Thrombosis
    Straight sinus
    Cerebral veins
    Stroke
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    Objective: To investigate recanalisation in the first 12 months after cerebral venous thrombosis. Methods: 33 consecutive patients presenting with cerebral venous thrombosis were enrolled in the study. Diagnosis was made by magnetic resonance imaging (MRI) and magnetic resonance venography (MRV) or catheter angiography. Patients were initially treated with intravenous heparin. Warfarin was given for at least four months. Cerebral MRI and MRV were done at four months and repeated after 12 months if venous thrombosis persisted. Outcome was evaluated by the Rankin scale at 12 months. Results: Outcome at 12 months was good, with a median modified Rankin scale score of 0 (range 0 to 2); 27 patients (82%) had no residual deficits. No patient suffered recurrent cerebral venous thrombosis, deep vein thrombosis, or pulmonary embolism during follow up. After four months, all deep cerebral veins and cavernous sinuses, 94% of superior sagittal sinuses, 80% of straight sinuses, 73% of jugular veins, 58% of transverse sinuses, and 41% of sigmoid sinuses had recanalised. No further recanalisation was observed thereafter. Conclusions: The results suggest that recanalisation only occurs within the first four months following cerebral venous thrombosis and not thereafter, irrespective of oral anticoagulation.
    Intracranial Thrombosis
    Cerebral veins
    Magnetic resonance angiography
    Venography
    Citations (161)
    Objiective To investigate the magnetic resonance imaging(MRI) and magnetic resonance venography(MRV) features of cerebral venous(sinus) thrombosis. Methods Data of 58 cases of cerebral venous( sinus) thrombosis were analyzed retrospectively, which were performed by MRI and MRV and treated with clinical therapy. All of the cases were scanned by MRI, 39 of which went on cerebral venous sinus 2D PC MRV, the signal changes of cerebral venous sinus, cerebral venous and intracranial were observed and analyzed. Result There are 49 cases with venous sinus thrombosis, in which 31 cases accompanied with single venous thrombosis; 8 cases accompanied with superfacial venous thrombosis, in which 3 cases occurred hemorrhage, 4 cases accompanied with deep cerebral venous thrombosis; there are 6 cases with deep cerebral venous sinus thrombosis and superfacial cerebral venous thrombosis; Single deep cerebral venous thrombosis were 9 cases. Conclusion The combination of MRI and MRV is one of the most effective, noninvasive methods for the diagnosis of cerebral venous(sinus) thrombosis.
    Cerebral veins
    Intracranial Thrombosis
    Sinus (botany)
    Straight sinus
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