Type of Oral Anticoagulant and Adverse Clinical Outcomes in Patients Extending Anticoagulation Therapy Beyond 90 Days After Hospitalization for VTE
1
Citation
5
Reference
10
Related Paper
Citation Trend
Abstract:
To the Editor We have several concerns about the recent study1 that demonstrated no significant difference in major bleeding with extended-duration direct oral anticoagulant (DOAC) therapy beyond 90 days after initial discharge for venous thromboembolism (VTE).Keywords:
Oral anticoagulant
Major bleeding
Anticoagulant Therapy
AbstractThe frequency of anticoagulant-related bleeding has been reported to range 1 – 7% per year, depending on the indication for anticoagulant therapy and the classification of bleeding. Although most bleeding is not life threatening, it does cause short-term morbidity and inconvenience to patients, as well as possibly diminishing their quality of life to some degree. Assessing the risk of anticoagulant-related bleeding is integral to optimising the management of anticoagulant therapy. Furthermore, early recognition and treatment of anticoagulant-related bleeding can reduce the associated morbidity. This article reviews the definitions of major and minor bleeding, the assessment of risk and preventive strategies and the management of anticoagulant-related bleeding.Keywordsanticoagulant therapybleedingmanagementrisk factors
Oral anticoagulant
Anticoagulant Therapy
Cite
Citations (10)
Anticoagulant Therapy
Cite
Citations (3)
To the Editor We have several comments about the recent study1 investigating the effect of anticoagulant therapy for 6 weeks vs 3 months on recurrence and bleeding in patients younger than 21 years old with provoked venous thromboembolism.
Anticoagulant Therapy
Major bleeding
Cite
Citations (0)
Forty-nine patients aged 65-89 years, treated for 6 months-6 years (mean 3.9 years) over a total of 195 patient years, were studied. The efficacy of anticoagulant control or the occurrence of complications or treatment failures did not vary with the age, sex, social status, mobility, visual acuity, domiciliary supervision of medication or the indication for anticoagulation. A significant correlation was observed between the concomitant drug therapy and anticoagulant control (P less than 0.001) but not with the occurrence of complications and treatment failures. Poor anticoagulant control was observed particularly in those receiving drugs known to potentiate warfarin effect and in whom more changes were made to their concomitant drug therapy. Five patients who experienced six non-fatal haemorrhages (two major and four minor) showed poor overall anticoagulant control from the outset (P less than 0.01). The treatment failure rate was 4%.
Oral anticoagulant
Anticoagulant Therapy
Cite
Citations (60)
Anticoagulant Therapy
Cite
Citations (0)
According to this study: Among patients younger than 21 years of age who have provoked venous thromboembolism, anticoagulant therapy for six weeks compared with three months met noninferiority criteria based on the trade-off between recurrent venous thromboembolism risk and bleeding risk.
Anticoagulant Therapy
Cite
Citations (0)
Removed teeth in patients receiving long-term oral anticoagulant drugs there are all the time live insure, very important and controversial problem in stomatological practice. Continuation of anticoagulation oral drugs exposure the patients so long haemorrhage while withdraw anticoagulant therapy to induce the risk of thromboembolism. The investigation were in 53 patients with prosthetic heart valves whose treated oral anticoagulant agents. The all patients have removed teeth without withdraw anticoagulant therapy. TachoComb administrated in alveoli post extraction teeth. The hemorrhage were in 4 (7.54%) cause.
Oral anticoagulant
Anticoagulant Therapy
Cite
Citations (0)
Anticoagulant Therapy
Oral anticoagulant
Major bleeding
Cite
Citations (34)
Anticoagulant Therapy
Cite
Citations (0)
Source Citation Schulman S, Granqvist S, Holmström M, et al., and the Duration of Anticoagulation Trial Study Group. The duration of oral anticoagulant therapy after a second episode of venous thromboembolism. N Engl J Med. 1997 Feb 6;336:393-8.
Anticoagulant Therapy
Oral anticoagulant
Cite
Citations (0)