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Mean platelet volume
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Citations (9)
Dilated Cardiomyopathy
Doppler imaging
Diastolic heart failure
Brain natriuretic peptide
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Citations (36)
To investigate the changes and significance of circulating IL-39 in patients with acute coronary syndrome (ACS).Serum IL-39 levels in ACS patients and normal coronary arteries were measured. The correlations of IL-39 with high-sensitivity CRP, cTnI, N-terminal of the prohormone brain natriuretic peptide (NTproBNP) and left ventricular ejection fraction were investigated.The serum levels of IL-39 in ACS patients were significantly increased. IL-39 levels were positively correlated with NTproBNP, high-sensitivity CRP and cTnI, negatively correlated with left ventricular ejection fraction in ACS patients. The most significant correlation arose between serum IL-39 and NTproBNP in STEMI patients (r = 0.8309; p < 0.0001).Circulating level of IL-39 might be a predictor of cardiac systolic dysfunction in ST-segment elevation myocardial infarction patients.
Brain natriuretic peptide
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Contractility
Brain natriuretic peptide
valvular heart disease
Afterload
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Citations (101)
Atrial fibrillation (AF) is associated with an increased risk of stroke and other thromboembolic events. Left atrial (LA) thrombus formation is closely related to LA dysfunction, particularly to decreased LA appendage flow velocity (LAA-FV) in patients with AF. We estimated LAA-FV using parameters noninvasively obtained by transthoracic echocardiography (TTE) in patients with paroxysmal AF.Echocardiographic and clinical parameters were assessed in 190 patients with nonvalvular paroxysmal AF showing sinus heart rhythm during transesophageal echocardiography (TEE) and TTE.LAA-FV (60 ± 22 cm/s) significantly correlated with the time interval between the initiation of the P-wave on ECG and that of the A-wave of transmitral flow on TTE (PA-TMF, correlation coefficient, -0.32; P < 0.001), LA dimension (LAD, -0.31; P < 0.001), septal a' velocity of tissue Doppler imaging (TDI, 0.35; P < 0.001), E/e' ratio (-0.28, P < 0.001), E velocity of transmitral flow (-0.20, P = 0.008), E/A ratio of transmitral flow (-0.18, P = 0.02), CHA2DS2-VASc score (-0.15, P = 0.04), and BNP plasma level (-0.32, P = 0.002). Multivariate analysis revealed that PA-TMF (standardized partial regression coefficient, -0.17; P = 0.03), a' velocity (0.24, P = 0.004), and LAD (-0.20, P = 0.01) were independent predictors of LAA-FV (multiple correlation coefficient R, 0.44; P < 0.001).Parameters of atrial remodeling, ie, decreased a' velocity, increased LAD, and PA-TMF during sinus rhythm may be useful predictors of LA blood stasis in patients with nonvalvular PAF. LAA-FV can be estimated using these TTE parameters instead of TEE.
P wave
Doppler imaging
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Citations (16)
Brain natriuretic peptide
Coronary arteries
Elevation (ballistics)
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Citations (34)
Left atrial enlargement
Univariate analysis
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Citations (100)
Left ventricular remodeling (LVR), an increase in left ventricular end-diastolic volume index > or = 20%, is an adverse consequence of myocardial infarction. The aim of this study was to assess the association between LVR and adiponectin, which has been shown to protect against myocardial ischemia-reperfusion injury.In 75 patients echocardiographic examination was performed one year after ST-segment elevation myocardial infarction, successfully treated with primary percutaneous coronary intervention (pPCI). Two groups of patients were analyzed: those with LVR (n = 15) and those without LVR (n = 60).The predictors of LVR were: anterior myocardial infarction, glucose at admission, baseline C-reactive protein, adiponectin, and echocardiographic parameters: left ventricular end-diastolic and end-systolic volume indices, ejection fraction < 40% and left ventricular wall motion score index (WMSI) at discharge. On multivariable regression analysis, lower adiponectin level (OR = 0.67, 95% CI 0.49-0.91, p < 0.05) and higher WMSI (OR = 20.14, 95% CI 2.62-154.82, p < 0.01) were the only independent negative predictors of LVR. The optimal cut-off for adiponectin for predicting LVR was < or = 4.7 mg/mL (sensitivity: 73%, specificity: 85%) and this level increased the risk of LVR 15-fold (95% CI 4.05-59.87, p = 0.0001).Baseline low blood adiponectin concentration, along with WMSI, can be considered as a predictor of the LVR in male patients one year after myocardial infarction and pPCI.
Ventricular remodeling
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Citations (9)
This study was performed to determine the relation between inducible sustained ventricular tachycardia (ISVT) by programmed electrical stimulation and angiographic, clinical and echographic data in patients with coronary artery disease. The aim of this study was to explore if these inducible arrhythmias are associated with any specific "arrhythmogenic" pattern of coronary artery disease. 129 consecutive patients with coronary artery disease and ISVT were evaluated by left ventriculography and coronary arteriography by standard techniques. The mean age of the patients was 46 years with a range of 21 to 72 years, 74% of them were males. A significant stenosis of the main left coronary artery (>50%) appeared to be more frequent in arrhythmia patients (31%). Also proximal left anterior descending artery stenosis was more frequent in in the arrhythmia patients (48%). "Main left equivalent" lesions, defined as a significant stenosis of the proximal left anterior descending artery and the proximal left circumflex artery was significantly more frequent among the arrhythmia patients (51%). Using the quantitive wall motion analysis, a strong relationship was found between the number of abnormally contracting segments and the presence of inducible sustained ventricular tachycardia. The results of the present study suggest that ISVT in patients with coronary artery disease are more frequently associated with lesions of the main left coronary artery or the proximal left anterior descending artery.
Circumflex
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Contractility
Creatine kinase
Abnormality
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Citations (24)