Chronological Development of Cardiovascular Disease in Times of COVID-19: A Retrospective Analysis of Hospitalized Diseases of the Circulatory System and COVID-19 Patients of a German University Hospital
3
Citation
30
Reference
10
Related Paper
Citation Trend
Abstract:
This study aims at examining the chronological development of hospitalized cardiovascular and COVID-19 patients and comparing the effects on related sub-disciplines and main diagnoses for pre-pandemic (2017-2019) and pandemic (2020-2021) years in the setting of a German university maximum care provider. Data were retrospectively retrieved from the hospital performance controlling system for patient collectives with main diagnosis of diseases of the circulatory system (nCirculatory) and COVID-19 secondary diagnosis (nCOVID-19). The cardiovascular patient collective (nCirculatory = 25,157) depicts a steady state in terms of relative yearly development of patient numbers (+0.4%, 2019-2020, +0.1%, 2020-2021). Chronological assessment points towards monthly decline during lockdowns and phases of high regional incidence of COVID-19 (i.e., 2019-2020: March -10.2%, April -12.4%, December -14.8%). Main diagnoses of congestive heart failure (+16.1% 2019/2020; +19.2% 2019/2021) and acute myocardial infarction show an increase in case numbers over the course of the whole pandemic (+15.4% 2019/2020; +9.4% 2019/2021). The results confirm negative effects on the cardiovascular care situation during the entire pandemic in the setting of a university maximum care provider. A general increase in cardiac disorders and a worrisome turn in case development of acute myocardial infarction emphasize the feared cardiovascular burden of COVID-19.Keywords:
2019-20 coronavirus outbreak
Pandemic
Coronavirus Infections
2019-20 coronavirus outbreak
Coronavirus Infections
Betacoronavirus
Coronavirus
Pandemic
Cite
Citations (7)
2019-20 coronavirus outbreak
Betacoronavirus
Coronavirus
Coronavirus Infections
Pandemic
Sars virus
Viral therapy
Cite
Citations (0)
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. However, bioinformatics tools designed explicitly for SARS-CoV-2 have only recently been developed as a rapid reaction to the need for fast detection, understanding and treatment of COVID-19. To control the ongoing COVID-19 pandemic, it is of utmost importance to get insight into the evolution and pathogenesis of the virus. In this review, we cover bioinformatics workflows and tools for the routine detection of SARS-CoV-2 infection, the reliable analysis of sequencing data, the tracking of the COVID-19 pandemic and evaluation of containment measures, the study of coronavirus evolution, the discovery of potential drug targets and development of therapeutic strategies. For each tool, we briefly describe its use case and how it advances research specifically for SARS-CoV-2. All tools are free to use and available online, either through web applications or public code repositories. Contact:evbc@unj-jena.de
2019-20 coronavirus outbreak
Coronavirus
Betacoronavirus
Pandemic
Coronavirus Infections
Sars virus
Cite
Citations (137)
Preview this article: Authors' response: Plenty of coronaviruses but no SARS-CoV-2, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/25/8/eurosurv-25-8-5-1.gif
2019-20 coronavirus outbreak
Coronavirus
Betacoronavirus
Coronavirus Infections
Sars virus
Cite
Citations (1)
2019-20 coronavirus outbreak
Coronavirus
Betacoronavirus
Coronavirus Infections
Sars virus
Pandemic
Cite
Citations (0)
Although SARS-CoV-2 may primarily enter the cells of the lungs, the small bowel may also be an important entry or interaction site, as the enterocytes are rich in angiotensin converting enzyme (ACE)-2 receptors. The initial gastrointestinal symptoms that appear early during the course of Covid-19 support this hypothesis. Furthermore, SARS-CoV virions are preferentially released apically and not at the basement of the airway cells. Thus, in the setting of a productive infection of conducting airway epithelia, the apically released SARS-CoV may be removed by mucociliary clearance and gain access to the GI tract via a luminal exposure. In addition, post-mortem studies of mice infected by SARS-CoV have demonstrated diffuse damage to the GI tract, with the small bowel showing signs of enterocyte desquamation, edema, small vessel dilation and lymphocyte infiltration, as well as mesenteric nodes with severe hemorrhage and necrosis. Finally, the small bowel is rich in furin, a serine protease which can separate the S-spike of the coronavirus into two "pinchers" (S1 and 2). The separation of the S-spike into S1 and S2 is essential for the attachment of the virion to both the ACE receptor and the cell membrane. In this special review, we describe the interaction of SARS-CoV-2 with the cell and enterocyte and its potential clinical implications.
2019-20 coronavirus outbreak
Coronavirus
Betacoronavirus
Coronavirus Infections
Sars virus
Pandemic
Coronaviridae
Cite
Citations (109)
Teaser: Our review found the average R0 for 2019-nCoV to be 3.28, which exceeds WHO estimates of 1.4 to 2.5.
2019-20 coronavirus outbreak
Betacoronavirus
Coronavirus
Coronavirus Infections
Pandemic
Cite
Citations (3,394)
2019-20 coronavirus outbreak
Betacoronavirus
Coronavirus Infections
Pandemic
Cite
Citations (28)
2019-20 coronavirus outbreak
Betacoronavirus
Coronavirus
Coronavirus Infections
Pandemic
Cite
Citations (29)
Preview this article: Note from the editors: novel coronavirus (2019-nCoV), Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/25/3/eurosurv-25-3-1-1.gif
Coronavirus
2019-20 coronavirus outbreak
Betacoronavirus
Coronavirus Infections
Cite
Citations (42)