Distinctive anti-inflammatory effects of resveratrol, dihydroresveratrol, and 3-(4-hydroxyphenyl)-propionic acid on DSS-induced colitis in pseudo-germ-free mice
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Anti-inflammatory
최근 들어 암소의 수태율와 관련된 수많은 생리활성물질들에 대한 연구결과이 보고되 어지고 있다. 이들 중 저농도의 resveratrol 처리에 따른 효과 관련 연구결과들에서 임신 호르몬인 progesterone (P4), estradiol-17β (E2) 등의 생리적인 변화에 따라 sirtuin (SIRT1)의 발현에 유의적인 차이가 나타난다고 보고하고 있다. 따라서 본 연구목적은 한 우 암소 자궁 내 resveratrol을 주입하여 암소의 수태율을 관찰하고 이를 바탕으로 P4, E2, SIRT1의 변화양상을 조사하고자 한다. 공시축은 생후 14개월령 미경산 암소 20두를 대상으로 체중, 십자부고, 흉위, BCS 등 을 측정한 후 대조군 5두, 0.5, 1.0, 2.0 μM resveratrol 처리군 각 5두씩 설정하여 주입하 였다. Resveratrol 주입에 대한 수태율 효과를 정확하게 분석하기 위해서 전체 실험축군 을 배란동기화 처리하였고 10일째 일괄 인공수정 하였다. Resveratrol은 7일째 자궁 내 두당 20 mL 주입하였다. 배란동기화로 예상되는 주요 발정일은 9일째이며, 9일째 발정이 확인된 개체는 0.5 μM Resveratrol 주입군에서 100%로 가장 높게 나타났으며 대조군은 40%, 1.0, 2.0 μM Resveratrol 주입군에서는 20%로 각각 확인되었다. 임신감정은 수정 후 40일 경과 후 초음파장비를 통해 수행하였으며 그 결과 발정확인률과 유사한 경향치 를 보이며 0.5 μM Resveratrol 주입군이 60%, 대조군은 40%, 1.0, 2.0 μM Resveratrol 주입군은 20%로 나타났다. 따라서 선행된 in vitro 수준의 연구결과와 동일하게 in vivo 수준에서도 저농도의 Resveratrol이 암소 수태율에 긍정적인 영향을 미친다는 것을 확인했으며, 추후 사전에 확보 한 혈액으로부터 serum을 추출하여 P4, E2 등의 주요 호르몬 수치변화와 SIRT1의 발현 여부를 분석하여 resveratrol이 어떠한 상호작용을 통하여 oocyte maturation과 embryonic development에 관여하는지 추가로 검증할 예정이다. 본 연구결과는 농가에서 쉽고 간편 하게 저비용으로 수태율을 향상시킬 수 있는 기술이기 때문에 한우 사육농가의 수익향상 에 기여할 수 있다고 기대된다.
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Objective: To establish whether liver targeting for resveratrol liposomes is better than resveratrol.Methods: Resveratrol liposomes were prepared using film ultrasonic dispersion method,then resveratrol and its liposomes were injected from mouse tail vein. The resveratrol's concentrations of mouse liver were measured using UV spectrophotometry and used as the investigation indexes. In order to determine the liver targeting differences between resveratrol and its liposomes we compaed the remainings of resveratrol in livers which injected resveratrol and its liposomes after 30 minutes,2 hours and 8 hours,respectively. Results: There was a larger resveratrol distribution amount in mice liver tissues by injecting resveratrol liposomes than resveratrol simply after 30 minutes,2 hours and 8 hours. Conclusion: Resveratrol liposomes possess better effect of liver targeting.
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Resveratrol has aroused significant scientific interest as it has been claimed that it exhibits a spectrum of health benefits. These include effects as an anti-inflammatory and an antitumour compound. The purpose of this study was to investigate and compare any potential antigrowth effects of resveratrol and two of its derivatives, acetyl-resveratrol and polydatin, on 3D cell aggregates of the EGFR/Her-2 positive and negative ovarian cancer cell lines SKOV-3 and OVCAR-8, respectively. Results showed that resveratrol and acetyl-resveratrol reduced cell growth in the SKOV-3 and OVCAR-8 in a dose-dependant manner. The growth reduction was mediated by the induction of apoptosis via the cleavage of poly(ADP-ribose) polymerase (PARP-1). At lower concentrations, 5 and 10 µM, resveratrol, acetyl-resveratrol, and polydatin were less effective than higher concentrations, 50 and 100 µM. In SKOV-3 line, at higher concentrations, resveratrol and polydatin significantly reduced the phosphorylation of Her-2 and EGFR and the expression of Erk. Acetyl-resveratrol, on the other hand, did not change the activation of Her-2 and EGFR. Resveratrol, acetyl-resveratrol, and polydatin suppressed the secretion of VEGF in a dose-dependant fashion. In the OVCAR-8 cell line, resveratrol and acetyl-resveratrol at 5 and 10 µM increased the activation of Erk. Above these concentrations they decreased activation. Polydatin did not produce this effect. This study demonstrates that resveratrol and its derivatives may inhibit growth of 3D cell aggregates of ovarian cancer cell lines via different signalling molecules. Resveratrol and its derivatives, therefore, warrant further in vivo evaluation to assess their potential clinical utility.
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Resveratrol 是拥护对许多人的癌症类型举办 chemopreventive 活动的饮食的多酚。我们首先报导 resveratrol 显著地减少雄激素依赖者和荷尔蒙倔强的前列腺癌症房间的增长。然而，特别地关于它的举起， subcellular 分发和细胞内部的目标，在上皮的正常前列腺和 stromal 房间的 resveratrol 的效果没被调查。在前列腺房间在可接近性和 resveratrol 的细胞的布置上推进知识，[ 3H ] resveratrol ，进 subcellular 分隔空间的房间摘录的分别，西方的污点分析， resveratrol 亲密关系列层析和流动 cytometry 被用来在通常有教养的前列腺 stromal ( PrSCs )和上皮的房间( PrECs )学习举起和 resveratrol 的细胞内部的分发。为有 resveratrol 的 2 天的 PrSCs 和 PrECs 的预告的处理调制了它的举起并且有选择地增加了它的分发到膜和细胞器分隔空间。Resveratrol 亲密关系列层析研究显示出以前识别的指向 resveratrol 蛋白质的微分表示， quinone reductase 2 (QR2 ) ，在 PrSCs 和 PrECs。比较对待 resveratrol 、未经治疗的 PrSCs 的流动 cytometric 分析在在房间周期的 S 和 G2/M-phases 的 G1 阶段和伴随物增加显示出大减少。这些结果建议 resveratrol 由影响房间周期阶段分发压制 PrSC 增长，它可以由 QR2 包含参予。
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Resveratrol is a naturally occurring phenolic compound abundantly found in grape skin and in wines. Resveratrol is a phytoalexin trans-3,5,4’-trihydroxystilbene that possesses diverse biochemical and physiological actions. It is effective in improving health and preventing or treating chronicdiseases. The cardiovascular protective effects of Resveratrol suggest the anti-atherogenic and anti-inflammatory activity of the compound on endothelial cells. Resveratrol attenuates myocardial ischemic reperfusion injury, atherosclerosis and reduces ventricular arrhythmias. Resveratrol has been widely studied and is shown to have anti-oxidant, anti-inflammatory, anti-proliferative and anti-angiogenic effects and many signalling pathways are among the molecular targets of Resveratrol. Based on these mechanistic considerations, the involvement of Resveratrol has been observed in cardiovascular diseases, cancer and neurodegenerative diseases. In type 2 diabetes patients, when Resveratrol was given along with anti-diabetic agents, it was found to lower blood glucose, HbA1C and increase the insulin sensitivity and the levels of HDL-C. Resveratrol acts on the SIRT1 gene and stimulates endogenous pathways to promote health and longevity.
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Resveratrol is a phytochemical that may promote health. However, it has also been reported to be a toxic compound. The molecular mechanism by which resveratrol acts remains unclear. The inhibition of the oxidative phosphorylation (OXPHOS) pathway appears to be the molecular mechanism of resveratrol. Taking this into account, we propose that the cytotoxic properties of resveratrol depend on the energy (e.g., carbohydrates, lipids, and proteins) availability in the cells. In this regard, in a condition with low energy accessibility, resveratrol could enhance ATP starvation to lethal levels. In contrast, when cells are supplemented with high quantities of energy and resveratrol, the inhibition of OXPHOS might produce a low-energy environment, mimicking the beneficial effects of caloric restriction. This review suggests that investigating a possible complex relationship between caloric intake and the differential effects of resveratrol on OXPHOS may be justified. Practical applications A low-calorie diet accompanied by significant levels of resveratrol might modify cellular bioenergetics, which could impact cellular viability and enhance the anti-cancer properties of resveratrol.
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This chapter contains sections titled: Introduction Chemical Overview of Resveratrol Sources of Resveratrol Epidemiologic Observations of Resveratrol Metabolism of Resveratrol Interaction of Resveratrol with Dietary Constituents Target Enzymes of Resveratrol Action Structure-Activity Relations of Resveratrol Pharmacological Preconditioning Effects of Resveratrol Antioxidant Power of Resveratrol Anti-Inflammation with Resveratrol Diabetes Cure with Resveratrol Cancer Cure with Resveratrol Antiaging Effects of Resveratrol Antiulcer Effects of Resveratrol Antiobese Effects of Resveratrol Other Health Benefits of Resveratrol Acknowledgment References
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Resveratrol is a polyphenol found in grapes, blueberries, mulberry and raspberry. Due to its antioxidant, anti-inflammatory, anti-microbial and anti-proliferative properties resveratrol has been reported to have health benefits in aging and age-related health disorders. While the actions of resveratrol and related polyphenols are likely multi-factorial, the anti-inflammatory of polyphenols are reasonably well documented.
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