Beta2 Agonists

but little is known about the of the course of when initial signs of a fixed airflow limitations are present.We aimed to study the quality of life (QoL) in asthma patients with fixed airflow limitation.Methods: 42 subjects with asthma were divided into groups: the 1st (n=20) with the signs of fixed airflow limitation (postbronchodilator FEV1/FVC<70%) and the 2nd group (n=22) without it.QoL was studied using SF-36 and AQLQ.The emotional status was assessed by the Hospital Anxiety and Depression Scale.Cold airway hyperresponsiveness was verified by 3-min isocapnic hyperventilation with cold air (IHCA).Results: In the 1st group compared with the 2nd group, pack-years smoked was higher (9.2AE2.1 vs. 3.1AE1.2,P=0.0169) and asthma control was lower (15.2AE1.0 vs. 19.1AE0.9 points АСТ, p=0.0093) against a higher level of depression (4.7AE0.7 vs. 1.9AE0.6 points, p=0.0081).By SF-36 only the Social Functioning did not have a significant difference.Other domains showed a significant worsening of QoL, including Role Physical (50.9AE6.8 vs. 83.2AE5.4 points, P=0.0006), Role Emotional (57.8AE8.2 vs. 84.0AE4.8 points, P=0.0079).The revealed correlation of Vitality with the level of anxiety (r=-0.75,P<0.01) and depression (r=-0.59,P<0.05) suggests a negative influence of psychological problems on the self-esteem of health in patients with fixed airflow limitation.AQLQ also revealed a significantly lower QoL for all domains.The correlation analysis showed the decrease of Activity Limitation is affected FEV1 drop in response to IHCA (r=0.6,P<0.05). Conclusion:The presence of fixed airflow limitation in asthmatics significantly decreases all the components of QL, lowers the asthma control and causes psychological problems.

B2 receptor

10.1111/resp.13700_316

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Effect of Polymorphisms in the Beta2-Adrenergic Receptor Gene (ADRB2) on Response to Long-Acting Beta2-Agonist (LABA) Therapy

Journal of Allergy and Clinical Immunology (2007)

Eugene R. Bleecker Dirkje S. Postma Rachael Lawrance Deborah A. Meyers Helen Ambrose

B2 receptor

10.1016/j.jaci.2006.12.632

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Citations (10)

Long-acting beta2-agonists versus theophylline for maintenance treatment of asthma