Subclinical hypothyroidism
2
Citation
11
Reference
10
Related Paper
Citation Trend
Abstract:
Subclinical hypothyroidism (SCH) is defined as an elevated serum thyroid-stimulating hormone level with a normal total and free thyroxine (T4) level. There is a certain degree of debate regarding the risks associated with this condition and whether treatment is beneficial. Individuals with SCH are either asymptomatic or present with milder symptoms than those with overt hypothyroidism. Although SCH does not cause significant clinical abnormalities, there are certain long-term consequences which have been documented. The diagnosis is based purely on biochemical investigations. Treatment of this condition is not indicated in all cases since thyroid function tests tend to normalize in 6%–35% of patients. However, there are specific clinical indications for treatment and oral levothyroxine is the treatment of choice in such situations.Keywords:
Subclinical infection
Levothyroxine
Subclinical hypothyroidism (SCH) is defined as an elevated serum thyroid-stimulating hormone (TSH) level with normal free thyroid hormone values. The prevalence of subclinical hypothyroidism is 3 to 8 percent in the general population, and up to 15 to 18 percent in women who are older than 60 years. It is more common in women than men, and its prevalence increases with age. Of patients with SCH, 80% have a serum TSH of less than 10 mIU/L. Management strategies including screening and treatment of subclinical hypothyroidism are still controversial. The strongest arguments for levothyroxine therapy are the high risk of progression to overt hypothyroidism. Initiating levothyroxine replacement therapy is recommended for all patients with a TSH greater than 10 mIU/L, even if the free thyroxine concentration is within normal laboratory range. However, treatment of patients with a serum TSH level between 5 and 10 mIU/L remains controversial. There was insufficient evidence for a clinically significant relationship between subclinical hypothyroidism and adverse cardiac events or cardiac dysfunction. Conflicting results have been found on the association between subclinical hypothyroidism and cognitive impairment, depression and the risk of fractures. This narrative review aims to assess current evidence on the clinical aspects, as well as screening and treatment recommendations in adults with subclinical hypothyroidism.J MEDICINE January 2017; 18 (1) : 30-36
Subclinical infection
Levothyroxine
Depression
Cite
Citations (5)
Objective To investigate the effect of low dose levothyroxine treatment on the patients with subclinical hypot hyroidism.Methods 30 subclinical hypothyroidism patients were trea ted by low dose levothyroxine,after treatment the serum lipids and thesymptoms were compared with those before treatment.Results After treatment the levels of serum total cholesterol,low densitylipo-protein and ApoB were significantly lower than those before treatment(P0.05),patients showed a-melioration in symptoms.Conclusion The low dose levothy roxinetreatment on the patients with subclinical hypothyroidism could sinificantly decrease the serum lipid level and ameliorate the symptom.
Levothyroxine
Subclinical infection
Cite
Citations (0)
Subclinical infection
Levothyroxine
Cite
Citations (14)
Objective:To investigate the effect of low dose of levothyroxine on the subclinical hypothyroidism.Methods:34 subclinical hypothyroidism patients were treated by low dose of levothyroxine, the serum lipids and the symptoms after treatment were compared with that before treatment.Results:After treatment the levels of serum tota1 cholestero1,low density lipoprotein were significantly lower than those before treatment(P0.05)and the patients showed amelioration in symptoms.Conclusion:The low dose of levothyroxine can significantly decrease the serum lipid level of the patients with subclinical hypothyroidism and ameliorate the symptom.
Subclinical infection
Levothyroxine
Cite
Citations (0)
There is increasing evidence indicating that considerable fractions of cases of SARS-CoV-2 infection are asymptomatic. We traced three asymptomatic clusters to investigate the infectivity of subclinical cases of coronavirus disease 2019 (COVID-19).Three medical staff who were asymptomatic were diagnosed with coronavirus disease 2019 by serological tests. Their close contacts were systematically evaluated based on COVID-19-related symptoms, nucleic acid tests, serological tests, and chest computed tomography (CT) as needed to determine if they were infected by SARS-CoV-2.None of the staff's close contacts, including 10 family members, were infected by the indexes, even though no protective measures were taken.The infectivity of asymptomatic subclinical infection patients of coronavirus disease 2019 seems to be low.
Subclinical infection
Coronavirus
Cite
Citations (2)
Objective To investigate the effect of Levothyroxine to the patients with subclinical hypothyroidism and clinical hypothyroidism. Methods Clinical data of 128 cases of patients with hypothyroidism in outpatients of our hospital from February 2010 to February 2012 were retrospectively analyzed, clinical hypothyroidism group had 46 cases, subclinical hypothyroidism group had 82 cases. They were all given oral levothyroxine sodium therapy. Blood lipid level in two groups were observed and compared. Results Level of TSH Subclinical before treatment in subclinical hypothyroidism group was lower than that in clinical hypothyroidism (P0.05), level of FT4 was higher than that in clinical hypothyroidism (P0.05); Levels of TC, TG, LDL after treatment in two groups were significantly decreased (P0.05), HDL decreased without significantly, the difference was not statistically significant (P0.05). TC in clinical hypothyroidism group after treatment dropped more than subclinical hypothyroidism group (P 0.05). Conclusion The application of Levothyroxine to the patients with subclinical hypothyroidism and clinical hypothyroidism can relieve clinical symptoms and improve the blood lipids.
Subclinical infection
Levothyroxine
Cite
Citations (0)
Levothyroxine
Subclinical infection
Cite
Citations (0)
Levothyroxine
Subclinical infection
Cite
Citations (0)
Objective To explore the efficacy of levothyroxine for the treatment of subclinical hypothyroidism.Methods 100 patients with subclinical hypothyroidism who had been treated in our hospital during the period of February 2010 to September 2012 were randomly selected.Various indexes and the efficacy were analyzed after treatment.Results After treatment with levothyroxine,the clinical symptoms improved significantly in the patients,and the indexes differed significantly,with a statistical difference (P＜0.05).Conclusions Levothyroxine is efficacious in the treatment of subclinical hypothyroidism.It can effectively prevent deterioration of the condition and normalize FT3,FT4,and TSH.
Key words:
Levothyroxine; Hypothyroidism; Efficacy
Levothyroxine
Subclinical infection
Clinical efficacy
Cite
Citations (0)
Subclinical hypothyroidism during pregnancy is associated with some adverse outcomes during maternal pregnancy.The present study investigated thyroid function parameters measured by electroehemiluminescence (ECL) immunoassays in subclinical hypothyroid women treated with levothyroxine (L-T4) during pregnancy.The results showed that in evaluating thyroid function with ECL immunoassays during replacement with L-T4,determination of serum TT4 appears to have a closer correlation with TSH and may better reflect the efficacy of treatment.
Key words:
Pregnancy ; Subclinical hypothyroidism ; Therapy ; Immunoassay ; Levothyroxine
Levothyroxine
Subclinical infection
Cite
Citations (0)