New bioactive lupane triterpene coumaroyl esters isolated from Buxus cochinchinensis
Lixia PanU Muñoz AcuñaH ChaiTN NinhLiva HarinantenainaEsperanza J. Carcache de BlancoDD SoejartoA. Douglas Kinghorn
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Abstract:
Five new lupane triterpene coumaroyl esters (1 – 5) were isolated from a CHCl3-soluble partition of a methanol extract of Buxus cochinchinensis Pierre ex Gagnep. (Buxaceae) collected in South Vietnam. Isolation work was monitored using human colon cancer cells (HT-29). The structures of the new compounds (1 – 5) were determined on the basis of spectroscopic data interpretation. In addition to the cytotoxicities against HT-29 cells and NF-κB (p65) inhibitory activities in an ELISA assay, all isolates were also evaluated for their in vitro antimalarial and antifungal activities.Keywords:
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The bark of the giant neem tree Melia dubia was found to contain 11 euphane-type triterpenes. Five new compounds, meliastatins 1-5 (1-5), proved to inhibit growth of the P388 lymphocytic leukemia cell line (ED(50) 1.7-5.6 microg/mL). Four of the others, the previously known methyl kulonate (8), kulinone (9), 16-hydroxybutyrospermol (10), and kulactone (11), were also found to inhibit (ED(50) 2.5-6.2 microg/mL) the P388 cancer cell line. In addition, two new euphane triterpenes were isolated and named dubione A (6) and dubione B (7). Structures for each of the 11 euphane triterpenes were established by spectral techniques that included HRMS and 2D NMR.
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