logo
    Systematic Evaluation of Research Progress on Natural Language Processing in Medicine Over the Past 20 Years: Bibliometric Study on PubMed (Preprint)
    Jing WangHuan DengBangtao LiuAnbin HuJun LiangLingye FanXu ZhengTong WangJianbo Lei
    0
    Citation
    51
    Reference
    10
    Related Paper
    Abstract:
    BACKGROUND Natural language processing (NLP) is an important traditional field in computer science, but its application in medical research has faced many challenges. With the extensive digitalization of medical information globally and increasing importance of understanding and mining big data in the medical field, NLP is becoming more crucial. OBJECTIVE The goal of the research was to perform a systematic review on the use of NLP in medical research with the aim of understanding the global progress on NLP research outcomes, content, methods, and study groups involved. METHODS A systematic review was conducted using the PubMed database as a search platform. All published studies on the application of NLP in medicine (except biomedicine) during the 20 years between 1999 and 2018 were retrieved. The data obtained from these published studies were cleaned and structured. Excel (Microsoft Corp) and VOSviewer (Nees Jan van Eck and Ludo Waltman) were used to perform bibliometric analysis of publication trends, author orders, countries, institutions, collaboration relationships, research hot spots, diseases studied, and research methods. RESULTS A total of 3498 articles were obtained during initial screening, and 2336 articles were found to meet the study criteria after manual screening. The number of publications increased every year, with a significant growth after 2012 (number of publications ranged from 148 to a maximum of 302 annually). The United States has occupied the leading position since the inception of the field, with the largest number of articles published. The United States contributed to 63.01% (1472/2336) of all publications, followed by France (5.44%, 127/2336) and the United Kingdom (3.51%, 82/2336). The author with the largest number of articles published was Hongfang Liu (70), while Stéphane Meystre (17) and Hua Xu (33) published the largest number of articles as the first and corresponding authors. Among the first author’s affiliation institution, Columbia University published the largest number of articles, accounting for 4.54% (106/2336) of the total. Specifically, approximately one-fifth (17.68%, 413/2336) of the articles involved research on specific diseases, and the subject areas primarily focused on mental illness (16.46%, 68/413), breast cancer (5.81%, 24/413), and pneumonia (4.12%, 17/413). CONCLUSIONS NLP is in a period of robust development in the medical field, with an average of approximately 100 publications annually. Electronic medical records were the most used research materials, but social media such as Twitter have become important research materials since 2015. Cancer (24.94%, 103/413) was the most common subject area in NLP-assisted medical research on diseases, with breast cancers (23.30%, 24/103) and lung cancers (14.56%, 15/103) accounting for the highest proportions of studies. Columbia University and the talents trained therein were the most active and prolific research forces on NLP in the medical field.
    Keywords:
    Preprint
    Biomedicine
    Topics:
    Biomedical Text Mining and Ontologies
    Artificial Intelligence in Healthcare and Education
    Machine Learning in Healthcare
    PDF
    In which I suggest a preprint archive for clinical trials
    Martin Fenner
    The ArXiv preprint archive for research articles in physics, mathematics, computer science and related disciplines was initiated by Paul Ginsparg in 1991. ArXiv enables the rapid dissemination of research articles prior to peer review, and it quickly became very successful in this.
    Preprint
    Citations (3)
    The Preprint Peer Reviewer's Toolkit: How to post a peer review of a preprint
    Gary S. McDowell
    This toolkit aims to help individual reviewers who read a preprint, and are motivated to give feedback to the authors, to be able to quickly and easily post their peer review report.
    Preprint
    Citations (1)
    The age of biomedicine: current trends in traditional subjects
    Journal of Applied Biomedicine (2011)
    Josef Berger
    The earliest scientific journals on biomedicine began publication in the 50s and their authors addressed the application of biology to medicine. More recently, biochemistry and biomedical engineering questions have figured more prominently. This trend is discussed in a survey of the topics appearing in the Journal of Applied Biomedicine. Pharmacological and toxicological articles have been popular over the long term and the neurosciences, chronomedicine, molecular and cell biomedicine have also been very important. The role of computational biomedicine and nanomedicine has received increasing attention as has the part which applied biomedicine can play in the enhancement of the general economy.
    Biomedicine
    Citations (31)
    Preprint servers to enhance access to scientific knowledge
    Khaled Moustafa
    Preprint servers can enhance the access to scientific knowledge by linking indexed papers in bibliography databases to their counterpart preprint versions whenever available. The current state of connection is to link preprints to their published versions in peer-reviewed journals. Here, I suggest the opposite. That is, linking indexed journal papers to their preprint versions wherever these are posted on a preprint server. Such linking from paid version (journals' articles) to their corresponding free preprint versions would make much sense as it removes the barrier to get access to pay walled papers for free.
    Preprint
    Citations (1)
    Vanishing and injectivity theorems for LMMP
    arXiv (Cornell University) (2007)
    Osamu Fujino
    This preprint has been withdrawn. It is because I will never publish this preprint since everything has been contained in my new preprint: arXiv:0907.1506. Please refer to arXiv:0907.1506. Please do not cite this preprint any more.
    Citations (19)
    The Importance of Preprint in Scientific Publication: Perspectives and Challenges
    The Journal of Social Sciences Research (2018)
    Carlos Miguel FerreiraSandro Serpa
    Currently, the possibility and interest in publishing in the preprint format are increasing, with more or less incidence in practically all scientific areas.Under these circumstances, the aim of this perspective opinion paper is to contribute to the discussion of the possible interest in publishing preprint.In order to meet this task of discussing preprint challenges and perspectives, we will analyse preprint, its potential advantages and limitations in comparison with other types of academic publications, looking at the future of preprint publication at two levels: in terms of communication and dissemination of science; and in terms of benefits for the academic career of the author of preprint publications.
    Preprint
    Citations (9)
    Electronic Preprints
    Highlights of Astronomy (1998)
    H. E. Payne
    Abstract Paper preprints are in decline in astronomy, while the use of electronic preprints is on the rise, mainly via the LANL astroph preprint archive. I discuss the decline of the paper preprint, some preprint servers available on the Web and some general electronic preprint issues, the astropharchive and its response to these issues, and alternatives for the future of electronic preprints.
    Preprint
    Electronic journal
    Citations (0)
    Peer Review of “Finding Potential Adverse Events in the Unstructured Text of Electronic Health Care Records: Development of the Shakespeare Method” (Preprint)
    Mark Antoniou
    UNSTRUCTURED This is a peer review report.
    Preprint
    Health records
    Electronic health record
    Citations (0)
    To Deliver Free Preprint Service for Physical Sciences. a Proposal for Further Development & Introduction to Www.sciprint.org
    viXra (2007)
    Carmen Caro CastroFlorentín Smarandache
    This proposal is intended to develop@@ a free digital preprint service for physical sciences to enable scientists/physicists publishing their preprint articles prior to submitting for formal publication in scientific journals, or perhaps they only want to see if their idea(s) received proper response prior to submitting it to journal editors.
    Preprint
    Scientific Publishing
    Citations (0)
    Predecessors of preprint servers
    Learned Publishing (2001)
    J. E. Till
    ABSTRACT Although there was an early experiment in the 1960s with the central distribution of paper preprints in the biomedical sciences, these sciences have not been early adopters of electronic preprint servers. Some barriers to the development of a ‘preprint culture’ in the biomedical sciences are described. Multiple factors that, from the 1960s, fostered the transition from a paper‐based preprint culture in high energy physics to an electronic one are also described. A new revolution in scientific publishing, in which journals come to be regarded as an overlay on electronic preprint databases, will probably overtake some areas of research much more quickly than others.
    Preprint
    Citations (23)