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Abstract:
The preparation of an extremely cheap and novel resin synthesised from a commercially available ion exchange resin is described.The free carboxylic acid group of the resin was converted into a methylester.Subsequent reduction of this ester to the corresponding alcohol has been carried out in one step, by using a solution of DIBAH as a reducing agent.The application of this resin for solid phase combinatorial synthesis has been evaluated by synthesizing 2 representative peptides and 2 selected 1,4-benzodiazepines.Implementation
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