Biphasic versus monophasic oral contraceptives for contraception
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Discontinuation
Pill
Clinical Research
Background: Reasons for treatment discontinuation are important not only to understand the benefit and risk profile of experimental treatments, but also to help choose appropriate strategies to handle intercurrent events in defining estimands. The current case report form (CRF) commonly in use mixes the underlying reasons for treatment discontinuation and who makes the decision for treatment discontinuation, often resulting in an inaccurate collection of reasons for treatment discontinuation. Methods and results: We systematically reviewed and analyzed treatment discontinuation data from nine phase 2 and phase 3 studies for insulin peglispro. A total of 857 participants with treatment discontinuation were included in the analysis. Our review suggested that, due to the vague multiple-choice options for treatment discontinuation present in the CRF, different reasons were sometimes recorded for the same underlying reason for treatment discontinuation. Based on our review and analysis, we suggest an intermediate solution and a more systematic way to improve the current CRF for treatment discontinuations. Conclusion: This research provides insight and directions on how to optimize the CRF for recording treatment discontinuation. Further work needs to be done to build the learning into Clinical Data Interchange Standards Consortium standards.
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A mathematical analysis model of a population of women of child bearing age is used to show the effect of contraceptive pill use on the number of expected live births. Two models were studied: 1) where the same number of women are taking the pill each month, and 2) where the same women are taking the pill monthly. It is concluded that if the population is structured around the second model, no month-by-month follow-up of the patients by a family planning program would be necessary to evaluate its success in fertility control.
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This paper addresses current issues associated with medication discontinuation in panic disorder, with specific focus on one of the most frequently used medication classes for this indication, the benzodiazepines. The majority of patients, when slowly tapered, are able to discontinue the benzodiazepines without a great deal of difficulty, particularly after short-term therapy. Patients treated with long-term therapy at high therapeutic doses may experience greater difficulty with discontinuation. If patients are adequately prepared and if discontinuation is conducted slowly and gradually, discontinuation symptoms, if they occur, are transient, mild to moderate, and generally tolerable. However, return of the original condition (relapse) during discontinuation can greatly complicate clinical management.
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Discontinuation of a crime can be divided into discontinuation of preparation of a crime, discontinuation of starting a crime,discontinuation of acting a crime and discontinuation of accomplished crime,negative and positive discontinuation,common discontinuation and quasi- discontinuation,damaged and non-damaged discontinuation and etc.Redefinition of the concepts of various discontinuation of a crime is helpful to the determination in judicial practice.
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The present research reports some results concerning the discontinuation of a long-term treatment with lithium in two groups of bipolar patients, BPI and BPII. The aim of the research is the evaluation of the causes leading to the discontinuation of the treatment and its effects. In all subjects the treatment, not combined with other medications, was effective for at least two years before discontinuation. The results show a percentage of recurrences similar to that reported by other Authors, with significant differences that point out a greater risk of recurrences after an abrupt discontinuation. The hypotheses concerning early recurrences are discussed, taking into account the different features of the recurrences in the two groups.
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There is concern that bluish skin discoloration associated with ezogabine treatment could be permanent. We present a case of ezogabine-induced skin discoloration that resolved completely after discontinuation. A 55-year-old woman started ezogabine 400 mg three times a day at age 41. Bluish pigmentation over the toe nails, finger nails, around eyes and over and around lips was first noted after 5 years of treatment. Ezogabine was discontinued eight years after initiation. Skin discoloration improved within 6 months and completely resolved within 6 years of discontinuation. This case suggests that ezogabine-induced discoloration is reversible after discontinuation of treatment.
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