NATAMYCIN
5
Citation
3
Reference
10
Related Paper
Citation Trend
Keywords:
Natamycin
Natamycin also called Pimaricin,is an important polyene macrolide fungicide. Its main producing strains are Streptomycesnatalensis,Streptomyces chmanovgensis and Streptomyces gilvosporeus,and so on. As a new food additive,natamycin is broad-spectrumed and highly efficient for suppressing and killing fungi. The physical,chemical properties and antimicrobial mechanism of natamycin was described in this paper,the application of natamycin in food industry was also referred.
Natamycin
Polyene
Cite
Citations (0)
Natamycin
Cite
Citations (1)
Natamycin
Cite
Citations (1)
The efficacy of natamycin (pimaricin) was studied and compared with the standard amphotericin B, using a reproducible model of keratomycosis from Candida albicans in the rabbit. C. albicans DSM 70010 (2.5 X 10(5) cells) was injected into the corneal stroma of both eyes. All eyes developed a corneal ulcer without pretreatment with immunosuppressive agents. Forty-eight hours after inoculation, the animals were divided into five groups: I (10 eyes) and II (12 eyes) receiving natamycin drops, 1%; groups III (12 eyes) and IV (12 eyes) receiving natamycin, 2.5%; the control group (14 eyes) receiving 0.9% NaCl. For better penetration of the drug, the epithelium of groups I and III was removed every 3rd day. Half of the control group was debrided as well. In a further series, the penetration of natamycin into the cornea and aqueous humor was studied. There was no difference between the treated eyes and the control eyes concerning complications (descemetocele or perforation). It is concluded that natamycin (pimaricin) is inferior to amphotericin B and not effective in controlling experimental keratomycosis.
Natamycin
Penetration (warfare)
Fungal Keratitis
Corneal perforation
Cite
Citations (2)
Natamycin is a poorly soluble, polyene macrolide antifungal agent used in the food industry for the surface treatment of cheese and sausages. This use is not of safety concern. However, highly soluble natamycin-cyclodextrin inclusion complexes have been developed for the protection of beverages. This practice leads to high drug exposures exceeding the safety level. Apart from the definition of an acceptable daily dietary exposure to natamycin, its effect on the faecal flora as a reservoir for resistance has to be examined. Consumption of food to which natamycin has been added and mixed homogeneously, such as yoghurt, and in particular the addition of cyclodextrin inclusion complexes to beverages and wine generates high faecal natamycin concentrations resulting in high drug exposures of faecal Candida spp. Development of natamycin resistance has been observed in Candida spp. colonising the intestinal tract of patients following natamycin treatment of fungal infections. Horizontal gene transfer among different Candida spp. and within Aspergillus fumigatus spreads resistance. Therefore, it cannot be denied that use of natamycin for preservation of yoghurt and beverages may foster development of resistance to polyenes in Candida spp.
Natamycin
Cite
Citations (39)
Natamycin
Fungal Keratitis
Cite
Citations (43)
Natamycin was one of natural microbial preservatives allowed in food,and had the efficient,safe,non-toxic,no side effect,etc.Very little dosage can play preservative effect.The structure,characteristics and the application in different types of food of natamycin were mainly introduced,and the prospects were expected.
Natamycin
Food Preservatives
Natural food
Cite
Citations (0)
Purpose: To determine if concurrent use of 5% natamycin and 2% econazole offers greater benefits than monotherapy with 5% natamycin for the management of fungal keratitis. Methods: Subjects presenting to the cornea service were treated with 5% natamycin and 2% econazole used concurrently. We compared the results with a historical control of patients treated with 5% natamycin in the same calendar year. The same clinical and examination protocol including inclusion and exclusion criteria was used for both groups. Results: We compared results of 47 subjects on concurrent use of 5% natamycin and 2% econazole with all 53 subjects who had received 5% natamycin in a previous study (historical controls). Baseline characteristics were similar between the 2 groups. There were no significant differences (P = 0.9) between the 2 arms for success (defined as a healed or healing ulcer). Conclusions: Concurrent use of 5% natamycin and 2% econazole does not appear to offer additional benefits over monotherapy with 5% natamycin for the management of fungal keratitis.
Natamycin
Econazole
Fungal Keratitis
Cite
Citations (28)
Natamycin is a polyene macrolide antifungal antibiotic and is an effective agent in treating fungal keratitis.This review summarizes the mechanism of action,antifungal activity and clinical application of natamycin by referring to the recent literature.
Natamycin
Fungal Keratitis
Polyene
Cite
Citations (0)
The application of Nisin and natamycin to pickle made by radish were studied.The result indicated that Nisin and natamycin could improve storing characteristics of pickle,and the optimum proportion of the natural compound preservatives was 300mg/kg Nisin +150mg/kg natamycin;Nisin and natamycin had little effect on total acidity of pickle ;sensory quality of pickle was improved during storage after treated by Nisin and natamycin.
Natamycin
Cite
Citations (0)