52Fe for additional marrow ablation before bone marrow transplantation

Total body irradiation(TBI) is a pre-treatment in patients with leukemia and other diseases before hematopoietic stem cell transplantation,which is widely accepted as preferred cure for leukemia and other diseases.In this paper,the author with nearly 26 years and about 600 cases of TBI patients treatment experience,introduced the TBI treatment indications and complications,equipment and apparatus,irradiation method and treatment planning,the absorbed dose measurement and calculation of prescribed dose.While the impact of dose rate on radiation pneumonia,total prescribed dose,dose estimates of lung tissue and eye lens,the real-time dose monitoring in treatment process and other relevant contents are also mentioned.The author wants these would be helpful to others.

Total body irradiation

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PO-1166 Total Body Irradiation (TBI) for hematopoietic stem cell transplantation

Radiotherapy and Oncology (2023)

U.A. Corro Verde U.A. Corro Verde Catalina Alonso J. Romero Fernández M. López Valcárcel

Total body irradiation

10.1016/s0167-8140(23)09163-6

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The effect of melphalan dose and total body irradiation as reduced-intensity conditioning for acute lymphoblastic leukemia patients undergoing allogeneic stem cell transplantation

Leukemia & lymphoma/Leukemia and lymphoma (2019)

Kaito Harada Takayoshi Tachibana Kazuteru Ohashi Yukiyasu Ozawa Masashi Sawa

To evaluate the prognostic impact of melphalan dose and total body irradiation (TBI) in acute lymphoblastic leukemia (ALL) patients undergoing reduced-intensity allogeneic transplantation, we retrospectively compared the outcomes between higher-dose melphalan (120–140 mg/m2) with (HDM/TBI+, n = 118) or without 2–4 Gy TBI (HDM/TBI−, n = 152) and lower-dose melphalan (80–110 mg/m2) with TBI (LDM/TBI+, n = 237). At 3 years, the overall survival was 49.6% in the HDM/TBI+, 51.7% in the HDM/TBI−, and 47.3% in the LDM/TBI + groups (p = .67). The relapse rate and non-relapse mortality were comparable among the three groups. Multivariate analysis revealed that conditioning regimen was not associated with overall survival, relapse, and non-relapse mortality; however, central nervous system complication was less frequent with LDM/TBI + than with HDM/TBI+. Our findings suggest reduced-intensity conditioning with LDM/TBI + might be a reasonable option, especially in vulnerable ALL patients, with similar transplant outcomes to HDM with or without TBI.

Total body irradiation

Melphalan

Regimen

10.1080/10428194.2019.1636986

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Citations (7)

Low dose total body irradiation (TBI) in outpatient non-myeloablative bone marrow transplantation

International Journal of Radiation Oncology*Biology*Physics (2003)

Roger M. Macklis M Kalaycio Ronald Sobecks Brad Pohlman Stacey Brown

Total body irradiation

10.1016/s0360-3016(03)01149-0

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