Antiischemic Effects of Nifedipine in Isolated Working Heart Preparations of Healthy, Diabetic, and Hypertensive Rats
2
Citation
0
Reference
10
Related Paper
Abstract:
Summary: We evaluated the antiischemic effects of nifedipine in isolated working rat hearts from age-matched normotensive Wistar-Kyoto rats (WKY), diabetic WKY, spontaneously hypertensive rats (SHR), and diabetic SHR. Diabetes was induced by streptozotocin. First, we constructed concentration-response curves for the negative inotropic effect of nifedipine in every group. After 15 min of pretreatment with nifedipine (EC60), low-flow ischemia (30 min) was induced by reducing the afterload from 51.5 to 11.0 mm Hg and nifedipine was infused simultaneously. The six measured parameters were left ventricular pressure (LVP), maximum rate of pressure increase (+ dP/dtmax), maximum rate of pressure decrease (− dP/dtmax), aortic output (AO), coronary flow (CF), and cardiac output (CO), determined after 15-min equilibration in the working heart mode and at the end of the experiment. From these data, the recovery percentages were calculated. There were no significant differences in sensitivity to nifedipine (as measured by the EC50 concentration) between the four groups with respect to LVP, + dP/dtmax, − dP/dtmax, CF, and CO. However, hearts from SHR were less sensitive to nifedipine than those from diabetic SHR and nondiabetic WKY with regard to AO. In isolated hearts from nondiabetic WKY and SHR, there were no significant differences between vehicle-treated organs and nifedipine-treated preparations. In hearts from diabetic WKY and diabetic SHR, however, the nifedipine-treated group (LVP 87.1 ± 3.3 and 60.5 ± 12.1%, respectively) recovered significantly (p < 0.05) better from ischemia as compared with the control group (LVP 35.7 ± 14.7 and 10.7 ± 9.8%, respectively) (n = 6 for each group). Hearts from diabetic rats treated with nifedipine recovered much better from ischemia than did hearts derived from nondiabetic rats.Keywords:
Afterload
Spontaneously hypertensive rat
Journal Article Improved myocardial capillarisation in spontaneously hypertensive rats treated with nifedipine Get access ZDENEK TUREK, ZDENEK TUREK **From the Department of Physiology, Catholic University, Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar KAREL KUBAT, KAREL KUBAT †From the Department of Pathological Anatomy, Faculty of Medicine, Catholic University, Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar STANISLAV KAZDA, STANISLAV KAZDA ‡From the Institute of Pharmacology, Bayer AG, Wuppertal, Federal Republic of Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar LOUIS HOOFD, LOUIS HOOFD **From the Department of Physiology, Catholic University, Nijmegen, The Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar KAREL RAKUSAN KAREL RAKUSAN §Department of Physiology, School of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 21, Issue 10, October 1987, Pages 725–729, https://doi.org/10.1093/cvr/21.10.725 Published: 01 October 1987 Article history Received: 03 September 1986 Accepted: 30 April 1987 Published: 01 October 1987
Spontaneously hypertensive rat
Cite
Citations (32)
Objective: To observe the hypotensive effect on DBP with nifedipine tardy-released tablets. Methods Eighty cases of hypertesion in the elderly were randomly divided mifedipine treatmental group and captopril group as control. Results The dffecti of nifedipine was siginficant than captopriil (P0.01).Condusions Nifedipine tardy-released tablet has certain valule in clinical treatment.
Captopril
Cite
Citations (0)
AIM To compare the pharmacokinetics of nifedipine sustained release tablets and nifedipine tablets in healthy volunteers.METHODS Twelve healthy male volunteers were divided into two groups,and received a single oral dose of nifedipine sustained release tablets and nifedipine tablets 20 mg,respectively.The plasma concentrations of nifedipine were determined by HPLC,and the pharmacokinetic parameters were calculated by DAS 2.1 software.RESULTS The pharmacokinetic parameters of nifedipine sustained release tablets and nifedipine tablets were as follows:ρmax were(1 247.8 ± 78.4)μg·L-1 and(1 896.7 ± 109.2)μg·L-1,tmax were(4.6 ± 0.7)h and(2.6 ± 0.9)h,t1/2 were(8.6 ± 2.8)h and(4.8 ± 1.5)h,AUC0-∞ were(5 879.3 ± 176.2)μg·h·L-1 and(3 724.9 ± 121.3)μg·h·L-1,AUC0-t were(4 427.8 ± 131.7)μg·h·L-1 and(2 936.5 ± 75.4)μg·h·L-1 respectively.The tmax and t1/2 of nifedipine sustained release tablets were significantly longer than that of nifedipine tablets,AUC0-t and AUC0-∞ were significantly higher than that of the nifedipine tablets,and ρmax was significantly lower than that of nifedipine tablets.CONCLUSION The nifedipine sustained release tablets have the sustained-release characteristics.
Cite
Citations (0)
ObjectiveTo invitro.MethodsPrimarily 在齿龈的成纤维细胞在骨胶原的表示上调查 nifedipine (钙隧道阻滞物) 的效果齿龈的成纤维细胞与 nifedipine (108 μ g/L， 360 μ g /L 和 1200 μ g /L ) 的各种各样的集中有教养、孵化 5 天了。齿龈的成纤维细胞主要是有教养的面对 360 μ g /L nifedipine 源于 nifedipine 应答者和非应答者。连接酶的免疫吸着剂试金被用来评估类型的数量我骨胶原。房间增长被房间与计算骨胶原的 MTT value.ResultsThe 表达式数测量，房间增长在第五天在高集中组和其它之中是显著地不同的，在 360 μg /L 和 1200 个 μg /L 组特别更高、在应答者和骨胶原和房间增长的 non-responders.ConclusionThe 表示可以涉及的 nifedipine 之中也不同为齿龈的增生的生物机制。
Cite
Citations (1)
Background: Cyclosporin A and nifedipine cause gingival overgrowth in rat, and the combined use of these drugs increases the overgrowth severity. Objective: The purpose of this study was to compare gingival overgrowth of rats of differents ages treated with cyclosporin A and nifedipine alone or given concurrently. Materials and methods: Rats 15, 30, 60 and 90 d old were treated with 10 mg/kg body weight of cyclosporin A and/or 50 mg/kg body weight of nifedipine in the chow. Results: Young rats showed evident gingival overgrowth with nifedipine, cyclosporin A, and cyclosporin A and nifedipine given concurrently. Adult rats did not show significant gingival alterations when treated with cyclosporin A and nifedipine alone. Nevertheless evident gingival overgrowth with alterations of the epithelium and connective tissue were observed when treated simultaneously with cyclosporin A and nifedipine. Conclusion: These results suggest that the combined effects of cyclosporin A and nifedipine on gingival overgrowth in rat is not age dependent.
Cite
Citations (12)
The effect of nifedipine on placental blood flow was investigated in spontaneously hypertensive rats (SHR) and compared with that in normotensive Wistar Kyoto rats (WKY) by means of the clearance of hydrogen gas generated by electrolysis. The placental blood flow of nifedipine-treated WKY (5,10 and 25 mg/kg) was significantly (p < 0.05) reduced compared with that of WKY control. On the other hand, the placental blood flow of nifedipine-treated SHR did not change compared with that of SHR control. These data suggest that nifedipine has different effects on placental blood flow in SHR and WKY.
Fetal weight
Placental Circulation
Cite
Citations (1)
Hydralazine
Spontaneously hypertensive rat
Cite
Citations (79)
1. Nifedipine induces relaxation in aortic segments from Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) of 5-week-, 3-month-, 6-month- and 1.5-year-old precontracted with 50 mM K+ or 0.1 microM noradrenaline (NA). 2. In WKY rat segments precontracted with K+, nifedipine relaxation was reduced at 1.5 years. However, in SHR segments, the greatest relaxation was observed at 1.5 years. The relaxation elicited by nifedipine in segments from WKY of 6-month and 1.5-year-old precontracted with NA was higher than that reached at 5-week- and 3-month-old. However, the relaxation induced in SHR of 6-month and 1.5-year-old was only higher than that obtained at 5-week-old. 3. Relaxations elicited by nifedipine in segments from WKY precontracted with K+ were smaller than those observed in age-matched SHR segments. 4. The endothelium positively and negatively modulates the relaxation to nifedipine in segments from SHR and WKY rats of different ages precontracted with K+, respectively. However, in segments of both strain precontracted with NA, endothelium removal did not alter the relaxations obtained at different ages. 5. These results suggest that the relaxation elicited by nifedipine: (1) depends on the strain, with a tendency to be greater in the hypertensive strain; (2) is negatively and positively modulated by endothelium in WKY and SHR, respectively, and (3) is influenced by age, and this influence depends on both the contractile agent and the strain.
Spontaneously hypertensive rat
Cite
Citations (2)
Cite
Citations (54)
Objective To study the prevalence of gingival overgrowth in patients induced by nifedipine. Methods 75 patients treated with nifedipine were periodontally examined while 134 other patients without the agent were regarded as controls. Results The prevalence of gingival overgrowth in the group of nifedipine was significantly higher than that of the controls. Conclusion It is suggested that nifedipine is a risk factor inducing gingival overgrowth.
Cite
Citations (0)