5-Fluorouracil induces defects in platelet function
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Platelet factor-3 (PF3) availability and platelet aggregation to ADP (4 μmol/l) and adrenaline (1.2 μmol/1) were evaluated in patients being treated with 5-fluorouracil (5-FU) for gastrointestinal malignancy. It produced a significant reduction in platelet aggregation and platelet factor-3 (PF3) availability (P <0.001) without being associated with thrombocytopenia. The changes in platelet aggregation occurred during the first week of chemotherapy and continued with subsequent courses. This acquired abnormality may be responsible for a haemorrhagic diathesis even without obvious thrombocytopenia. Study of platelet function is important and may be considered to assess the haematological toxicity in patients being treated with systemic 5-FU therapy.Keywords:
Bleeding diathesis
Abnormality
Diathesis
Objective To make full use of compositive diathesis evaluation,the dynamic progress effectiveness of undergraduates with different genders was calculated.Methods Based on Data Envelopment Analysis,we defined the ratio of actual output divided by ideal value asprogress effectivenessto truly reflect the diatheses developments of undergraduates.Results The progress effectiveness in both male undergraduates and females was about 0.82 in 2011,September and there was no statistical significance between them(F = 2.293,P = 0.130).In the sub-diatheses,the progress effectiveness of the males were higher than those of the females in scientific and culture diathesis,corporeity diathesis and basic ability diathesis(F= 6.742,16.936,6.607, P0.05).The progress effectiveness in both male undergraduates and females was higher than 0.92 in 2012,May and those of females were all higher than those of the males in compositive diathesis and the sub-diatheses(F = 20.407,17.861,19.586,17. 937,18.511,10.324,24.571,P 0.05).Conclusion Progress Effectiveness of Compositive Diathesis of Undergraduates was a continuous dynamic course.At first scientific and culture diathesis,corporeity diathesis and basic ability diathesis of the males promote more,and later all the diatheses of the females boost more.
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Hemorrhagic diathesis is a collective term. It includes hemophilia, Verlhof's disease, Schnlein-Henoch's disease and scorbutus. Bleeding is something common that unites these diseases, different in their clinical manifestations and, undoubtedly, in their pathogenesis. It is true that due to the development of the teaching of vitamins, scorbutus has fallen out of the purview of hematologists and is now closely related to problems of nutrition. Nevertheless, every clinical case of bleeding, especially accompanied by bleeding gums and spontaneous bruising, always makes the clinician first of all exclude scorbutus and then focus his attention on other forms of hemorrhagic diathesis.
Hemorrhagic diathesis
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Bleeding diathesis
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Information diathesis is one of the basic diathesis that modern society people should have, while teachers , who are shouldering the training of talents in new era, should have this diathesis especially. This paper analyzed the importance of strengthening information diathesis for LiangKe teachers and put forward strategy and ways for how to improve their information diathesis.
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This paper discussed the importance of diathesis education through the analysis on both domestic and overseas environment in new century. And the author gived us several useful methods about how to improve the diathesis education.
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Bleeding diathesis as a cause of menorrhagia should not be overlooked at any age even in the perimenopausal woman. Three cases have been presented, wherein bleeding diathesis was the cause of menorrhagia. Two of these patients had acute myeloid leukaemia and the third had immunothrombocytopaenic purpura. A noteworthy point of this series is that one patient was in her teens, the second in the peak reproductive age group and the third in the perimenopausal age.
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Hemorrhagic diathesis
Purpura (gastropod)
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The author tested the blood of 79 children with various manifestations of exudative diathesis, mainly from 3 months to 1 year of age, for eosinophilia. An elevated percentage of eosinophils was found in 65.8% of all these children.
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Bleeding diathesis
Hemorrhagic diathesis
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Scientific Research Question: Inherited platelet disorders (IPD) comprise rare and heterogeneous disorders that are found in about eight percent of patients with non-acquired bleeding diathesis. Identification of the underlying defective cellular mechanism is an important criterion for stratifying the patient's individual risk profile and for choosing personalised therapeutic options. In this study, we aimed to identify molecular diagnoses in a cohort of patients with suspected, but so far genetically undefined IPD by using high-throughput sequencing techniques.
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Bleeding diathesis
Blood Platelet Disorders
Genetic diagnosis
Platelet disorder
Identification
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To heighten the physiology and the psychological diathesis of the armyman in the modern war, it is expounded in this article that the causing ill factor of the physiology abnormality of the armyman in the war, the countermeasures should be adopted for preventing the armyman psychological abnormality. The experience should be provided for reducing the non fight depletion of numbers.
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Abnormality
Abnormal psychology
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Scientific Research Question: Inherited platelet disorders (IPD) comprise rare and heterogeneous disorders that are found in about eight percent of patients with non-acquired bleeding diathesis. Identification of the underlying defective cellular mechanism is an important criterion for stratifying the patient's individual risk profile and for choosing personalised therapeutic options. In this study, we aimed to identify molecular diagnoses in a cohort of patients with suspected, but so far genetically undefined IPD by using high-throughput sequencing techniques.
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Bleeding diathesis
Blood Platelet Disorders
Genetic diagnosis
Platelet disorder
Identification
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Introduction: Dengue fever is a mosquito-borne viral disease caused by dengue virus (DENV) - a single stranded RNA virus, belongs to the genus Flavivirus. Objective: To determine the frequency of bleeding diathesis amongst patients presenting with dengue fever in tertiary care hospital Methodology: This study was descriptive cross-sectional piloted at the Medicine Department, Hayatabad Medical Complex, Peshawar for duration of six months from June 2021 to December 2021. Totally 135 patients were included in our study. All the information like gender, age, sign and symptoms and bleeding diathesis were recorded on predesigned Performa. All the data was analyzed by using SPSS version 24. Results: In this study, a total of 135 patients were included. Amongst 135, 90(66.7%) were males and female were 45(33.3%). Bleeding Diathesis among 135 patients was observed in 47(34.8%) patients. Conclusion: Our study concludes that bleeding diathesis commonly occur in dengue patients. As a result, screening for coagulation abnormalities and treating them early may assist to prevent additional consequences in dengue patients. Keywords: Bleeding; Diathesis, Dengue fever
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Tertiary care
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