Papillon-LefÈvre Syndrome: Report of Two Cases in Siblings
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Background: Long-term treatment with low to moderate dosages of the antimetabolite and antifolate medication methotrexate (MTX) has been shown to be effective, safe, and well-tolerated for a wide range of autoimmune diseases.As a result, methotrexate may be used to treat vitiligo and other autoimmune disorders.The hepatotoxic and hematologic side effects of the drug's topical formulations, which were developed for the treatment of localized lesions, were deemed to be clinically insignificant.Objective: This review article aimed to assess the possible role of topical methotrexate in the management of vitiligo.Methods: Methotrexate, and the vitiligo were all looked for in PubMed, Google scholar, and Science direct.References from relevant literature were also evaluated by the authors, but only the most recent or complete studies from January 2005 to May 2021 were included.Due to the lack of sources for translation, documents in languages other than English were ruled out.Papers that did not fall under the purview of major scientific investigations, such as unpublished manuscripts, oral presentations, conference abstracts, and dissertations, were omitted.Conclusion: Topical methotrexate use could be an effective and safe treatment modality of vitiligo.
Vitiligo
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History
A 61-year-old housewife first noted symptoms of Raynaud phenomenon and cutaneous scleroderma in 1963. Progressive dyspnea with pulmonary fibrosis and rightsided cardiac failure began in 1969. Since 1973, she has had intermittent episodes of cramping abdominal pain with nausea along with dyspnea, cough, and loss of weight. In November 1974, the patient was hospitalized because of progressive abdominal pain and vomiting. Physical examination demonstrated advanced skin changes of scleroderma, signs of pulmonary hypertension, and cardiac failure. The abdomen was distended but soft and nontender. Bowel sounds were normal. Results of laboratory studies were normal except for findings indicative of moderate malabsorption. Figures 1 through 3 were obtained on this admission.Diagnosis
Scleroderma of the skin, lung, esophagus, and the small bowel, complicated by pneumatosis cystoides intestinalis and pneumoperitoneum.Comment
The chest roentgenogram (Fig 1) shows diffuse pulmonary fibrosis and cor pulmonale as well as congestive heart failure. Free airScleroderma (fungus)
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Бұл зерттеужұмысындaКaно моделітурaлы жәнеоғaн қaтыстытолықмәліметберілгенжәнеуниверситетстуденттерінебaғыттaлғaн қолдaнбaлы (кейстік)зерттеужүргізілген.АхметЯссaуи университетініңстуденттеріүшін Кaно моделіқолдaнылғaн, олaрдың жоғaры білімберусaпaсынa қоятынмaңыздытaлaптaры, яғнисaпaлық қaжеттіліктері,олaрдың мaңыздылығытурaлы жәнесaпaлық қaжеттіліктерінеқaтыстыөз университетінқaлaй бaғaлaйтындығытурaлы сұрaқтaр қойылғaн. Осы зерттеудіңмaқсaты АхметЯсaуи университетіндетуризмменеджментіжәнеқaржы бaкaлaвриaт бaғдaрлaмaлaрыныңсaпaсынa қaтыстыстуденттердіңқaжеттіліктерінaнықтaу, студенттердіңқaнaғaттaну, қaнaғaттaнбaу дәрежелерінбелгілеу,білімберусaпaсын aнықтaу мен жетілдіружолдaрын тaлдaу болыптaбылaды. Осы мaқсaтқaжетуүшін, ең aлдыменКaно сaуaлнaмaсы түзіліп,116 студенткеқолдaнылдыжәнебілімберугежәнеоның сaпaсынa қaтыстыстуденттердіңтaлaптaры мен қaжеттіліктерітоптықжұмыстaрaрқылыaнықтaлды. Екіншіден,бұл aнықтaлғaн тaлaптaр мен қaжеттіліктерКaно бaғaлaу кестесіменжіктелді.Осылaйшa, сaпa тaлaптaры төрт сaнaтқa бөлінді:болуытиіс, бір өлшемді,тaртымдыжәнебейтaрaп.Соңындa,қaнaғaттaну мен қaнaғaттaнбaудың мәндеріесептелдіжәнестуденттердіңқaнaғaттaну мен қaнaғaттaнбaу деңгейлерінжоғaрылaту мен төмендетудеосытaлaптaр мен қaжеттіліктердіңрөліaйқын aнықтaлды.Түйінсөздер:сaпa, сaпaлық қaжеттіліктер,білімберусaпaсы, Кaно моделі.
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The nationally-recognized Susquehanna
Chorale will delight audiences of all
ages with a diverse mix of classic and
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performances have been described
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music making, successful in their
aim to make the audience feel,
to be moved, to be part of the
performance - and all this while
working at an extremely high
musical level.AÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂA¢AÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂAÂA Experience choral
singing that will take you to new
heights!
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