The abuse potential of prolintane in rodents: Behavioral pharmacology approaches

For the identification and quantitative analysis of methamphetamine and its metabolites in the urine from a habitual user of the stimulant, the combined method of gas chromatography and mass fragmentgraphy was developed. The proportion of methamphetamine and its metabolites to the excreted matter is as follows : amphetamine 7.5%, p-hydroxymethamphetamine 6.45%, p-hydroxyamphetamine 0.35%, and norephedrine 0.23% respectively.

Methamphetamine

Stimulant

10.1248/jhs1956.29.5_318

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Citations (5)

Exploring brain morphology in poly-stimulant abuse: shape, volume, and surface area abnormalities in Ecstasy-cocaine- and methamphetamine-preferring individuals

Drug and Alcohol Dependence (2014)

Doris Payer Min Tae M Park Stephen J. Kish Jason P. Lerch Isabelle Boileau

Methamphetamine

Bupropion

Efflux

Conditioned place preference

Ecstasy

10.1016/j.drugalcdep.2014.09.546

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Citations (2)

Comparison of the effects of methamphetamine, bupropion, and methylphenidate on the self-administration of methamphetamine by rhesus monkeys.

Experimental and Clinical Psychopharmacology (2011)

Charles W. Schindler Joanne P. Gilman Leigh V. Panlilio David J. McCann Steven R. Goldberg

The effectiveness of methadone as a treatment for opioid abuse and nicotine preparations as treatments for tobacco smoking has led to an interest in developing a similar strategy for treating psychostimulant abuse. The current study investigated the effects of three such potential therapies on intravenous methamphetamine self-administration (1 - 30 μg/kg/injection) in rhesus monkeys. When given as a presession intramuscular injection, a high dose of methamphetamine (1.0 mg/kg) decreased intravenous methamphetamine self-administration but did not affect responding for a food reinforcer during the same sessions. However, the dose of intramuscular methamphetamine required to reduce intravenous methamphetamine self-administration exceeded the cumulative amount taken during a typical self-administration session, and pretreatment with a low dose of methamphetamine (0.3 mg/kg) actually increased self-administration in some monkeys at the lower self-administration dose. Like pretreatment with methamphetamine, pretreatment with bupropion (3.2 mg/kg) decreased methamphetamine self-administration but did not affect responding for food. Pretreatment with methylphenidate (0.56 mg/kg) did not significantly alter methamphetamine self-administration. These results suggest that some agonist-like agents can decrease methamphetamine self-administration. Although the most robust effects occurred with a high dose of methamphetamine, safety and abuse liability considerations suggest that bupropion should also be considered for further evaluation as a methamphetamine addiction treatment.

Methamphetamine

Self-administration

Bupropion

Abuse liability

10.1037/a0022432

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Citations (29)

Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats

Neuropharmacology (2009)

Dean S. Carson Jennifer L. Cornish Adam J. Guastella Glenn E. Hunt Iain S. McGregor

Methamphetamine

Self-administration

10.1016/j.neuropharm.2009.06.018

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Citations (143)

Behavioral effects of four novel synthetic cathinone analogs in rodents

Addiction Biology (2020)

Michael B. Gatch Ritu A. Shetty Nathalie Sumien Michael J. Forster

Abstract A new generation of novel cathinone compounds has been developed as stimulant substitutes to avoid drug control laws and detection of use by blood tests. Dipentylone, N ‐ethylhexedrone, 4‐chloroethcathinone (4‐CEC), and 4′‐methyl‐α‐pyrrolidinohexiophenone (MPHP) were tested for in vivo psychostimulant‐like effects to assess their abuse liability. Locomotor activity was assessed in an open‐field assay using Swiss–Webster mice to screen for locomotor stimulant effects and to identify behaviorally‐active dose ranges, times of peak effect, and durations of action. Discriminative stimulus effects were assessed in separate groups of Sprague–Dawley rats trained to discriminate cocaine or methamphetamine from vehicle. Dipentylone, N ‐ethylhexedrone, 4‐CEC, and MPHP dose‐dependently increased locomotor activity. Dipentylone, N ‐ethylhexedrone, and MPHP produced maximal stimulant effects similar to cocaine and methamphetamine. 4‐CEC was less efficacious, producing peak stimulant effects of about 74% of that of methamphetamine. The compounds were less potent than methamphetamine and approximately equipotent with cocaine. The doses of cocaine, methamphetamine, dipentylone, and 4‐CEC that produced peak effects lasted 2 to 3 h, the peak dose of N ‐ethylhexedrone lasted 4 h, and the peak dose of MPHP lasted 6 h. All four compounds fully substituted for the discriminative stimulus effects of methamphetamine and cocaine, although full substitution by 4‐CEC occurred at doses that substantially decreased response rate. Only 4‐CEC fully substituted for MDMA. These data provide evidence that the novel cathinone compounds dipentylone, N ‐ethylhexedrone, 4‐CEC, and MPHP demonstrate potential for abuse as psychostimulants, given their ability to stimulate locomotor activity and their substitution for the discriminative stimulus effects of methamphetamine and cocaine.

Stimulant

Methamphetamine

Cathinone

Locomotor activity

MDMA

Dextroamphetamine

10.1111/adb.12987

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Citations (21)

Agmatine attenuates methamphetamine-induced conditioned place preference in rats

European Journal of Pharmacology (2012)

David A. Thorn J.C. Winter Jun‐Xu Li