Immunogenetics: the developmental course
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Histocompatibility
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Human histocompatibility leukocyte antigen(HLA)-E is a nonclassical major histocompatibility complex (MHC)class I molecule,which is the 4th major histocompatibility complex (MHC)class I molecule that human have found following up that of HLA-A ,B,C. HLA-E is distinguished from the classical MHC class I molecule by limited allelic polymorphism,low expression on the cell surface and extensive tissue distribution.Human have paid great attention to the important role of HLA-E that it plays in maternal-placental immunological tolerance,transplantation immunization. as well as antitumor and antiviral immunity .
Histocompatibility
Histocompatibility Testing
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Abstract The application of unrelated donor hematopoietic cell transplantation can be expanded with the use of mismatched donors if human leukocyte antigen (HLA) disparity does not lead to increased morbidity and mortality. The rules that govern permissibility of HLA mismatches are not well defined. The International Histocompatibility Working Group in hematopoietic cell transplantation measured the risks associated with locus‐specific disparity in 4796 patients transplanted for low, intermediate, or high‐risk hematologic diseases. The permissibility of a given HLA mismatch is in part defined by the locus and by disease risk.
Histocompatibility
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Minor histocompatibility antigen
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Histocompatibility
Immunogenetics
Histocompatibility Testing
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The recent increase of immunopeptidomics data, obtained by mass spectrometry or binding assays, opens up possibilities for investigating endogenous antigen presentation by the highly polymorphic human leukocyte antigen class I (HLA-I) protein. State-of-the-art methods predict with high accuracy presentation by HLA alleles that are well represented in databases at the time of release but have a poorer performance for rarer and less characterized alleles. Here, we introduce a method based on Restricted Boltzmann Machines (RBMs) for prediction of antigens presented on the Major Histocompatibility Complex (MHC) encoded by HLA genes—RBM-MHC. RBM-MHC can be trained on custom and newly available samples with no or a small amount of HLA annotations. RBM-MHC ensures improved predictions for rare alleles and matches state-of-the-art performance for well-characterized alleles while being less data demanding. RBM-MHC is shown to be a flexible and easily interpretable method that can be used as a predictor of cancer neoantigens and viral epitopes, as a tool for feature discovery, and to reconstruct peptide motifs presented on specific HLA molecules.
Antigen processing
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Histocompatibility
Histocompatibility Testing
Minor histocompatibility antigen
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Abstract The ‘MHC and Infection’ study of the 14th International HLA and Immunogenetics Workshop was undertaken to evaluate the contribution of specific variants of major histocompatibility complex (MHC) and non‐MHC genes that are specifically associated with higher probabilities of infection, disease severity, and progression in different populations.
Immunogenetics
Histocompatibility
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Histocompatibility
Immunogenetics
Histocompatibility Testing
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Immunogenetics
Histocompatibility
Histocompatibility Testing
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