Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19
Jeffrey S. BergerLucy Z. KornblithMichelle N. GongHarmony R. ReynoldsMary CushmanYu ChengBryan J. McVerryKeri S. KimRenato D. LópesBassel AtassiScott BerryGrant V. BochicchioMurillo de Oliveira AntunesMichael E. FarkouhYonatan GreensteinErinn M. HadeKristin HudockRobert C. HyzyPooja KhatriAndrei KindzelskiBridget‐Anne KirwanLisa Baumann KreuzigerPatrick R. LawlerEric LeiferJose Lopez-Sendon MorenoJosé López‐SendónJames F. LutherLília Nigro MaiaJohn G. QuigleyRobert SherwinLana WahidJennifer G. WilsonJudith S. HochmanMatthew D. NealJonathan NewmanMark W. GeraciAldo P. MaggioniHooman KamelEwan C. GoligherRyan ZarychanskiBrendan M. EverettSean van DiepenGrégoire Le GalDeborah SiegalJ.‐P. GalanaudSheila M. HegdeYuri KimNatalia S RostAneesh B. SinghalAira ContrerasStephanie MavromichalisEduardo IturrateMargaret GilsenanAnna K. NaumovaArlene RobertsJulia LevineChristine M. LeeperDerek AngusMary MartinezJake SchreiberJoshua FroessCaroline E. StehleAshita Sai VadlamudiFrank C. SciurbaAlison MorrisEdvin MusicSophie de BrouwerEmilie PerrinCaroline GombaultSandra BulaMichael NelsonCéline DaelemansLaurine ParazMichelle A. DetryAnna McGlothlinMelanie QuintanaAmy CrawfordDanielle SinE. DièneEwelina GwiszczIsabelle HoganA HoldenNancy RingwoodLaura FitzgeraldHaley MorinBrenda Nunez‐GarciaAaron E. KornblithCarolyn M. HendricksonDeanna LeeViet NguyenIndia ShelleyShannon BroaddrickNeha AtalDavid T. HuangRenee WunderlyMeredith BuxtonTracey RobertsKelsey LinstrumAmanda McNamaraAlexandra WeissmanDylan BarbeeEmily BerrymanJamey FrasureAmy SulkenJéssica Natuline IanofLilian MazzaJulia MorataCarolina Martins CafarellaMayra Akimi SuiamaDaniele de Lima FrancoJorge EscobedoAndrea MartinezPedro OharaDouglas AssisChiara ManzaliniStefania CorsiGianluca CampoPaula PrietoRocio PrietoShamila GargRicardo FonsecoStacey ReeseOluwayemisi MohammedRowena J DolorThomas L. OrtelCameron R. WolfeMichael PlumpRahul NairWilliam NkemdirimJen‐Ting ChenBenjamin GalenAri MoskowitzNorma KellerEugene YuriditskyJames M HorowitzAlexander HindenburgTamta ChkhikvadzeLynnie BassoliTibério CostaJosé Luis López-SendónF. Rodríguez JorgeSebastian García MadronaRaquel Morillo GuerreroM. Alpañés BuesaRosa Nieto RoyoRaquel Besse DiazSergio Diz FariñaAndres Gonzalez GarcíaOsvaldo Da Silva JúniorCássia PradelaCláudio JorgeMariana Buka BukaOsana CostaDanielli FrassattoJuliana VieiraPaulo DutraLarissa Giannini Alves MoreiraNatalia da SilvaNadielly PradoAna MartinsAnna Helena Felipe Pereira CenturioneAlexandre de Matos SoeiroPaulo CaramoriNicola CoppolaMarco ContoliEsteban López de SáFernando WornerAmparo López‐BernúsJosé Ramón González‐JuanateyJesús PeteiroSheetal GandotraVidya KrishnanRobert WidmerLewis SatterwhiteAnthony MacchiavelliNicholas HannaHemali PatelRadmila LyubarovaEleonora GashiÁlvaro AlonsoStephen PanSrikanth VallurupalliNicole M. IovineRanjit NairAshwin JathavedamAmish ShahAbhijit DuggalAkram KhanMichael A. MatthayMatthew E. PrekkerGeorge LimS.C. MooreTodd W. CostantiniMatthew KutcherBellal JosephMichael BrombergMark B. EffronAllyson M. PishkoJohn P. SheehanManila GaddhKeyvan RezaïJulius Gene LatorreConrad W LiangZahra AjaniStephanie GuoMicah R. Whitson
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Platelets represent a potential therapeutic target for improved clinical outcomes in patients with COVID-19.Keywords:
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Alles auf einen Blick: Auf der Webseite der DRG erhalten Sie aktuelle Informationen der Radiologie zur SARS-CoV-2-Pandemie. Dort finden Sie beispielsweise Empfehlungen für die radiologische Versorgung oder zur unterstützenden Diagnostik durch die CT.
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To review current concepts in the diagnosis of adrenocortical disease in the critically ill patient.A review of articles reported on adrenocortical insufficiency in the acutely ill patient.The contribution of adrenal insufficiency to the morbidity of critically ill patients is currently under renewed scrutiny. The debate continues about the role of steroids in sepsis and essentially the question remains unanswered. Central to this debate is the issue of whether adrenal insufficiency is common in the critically ill patient. What is incontrovertible is that adrenocortical function is essential for host survival during critical illness, but what constitutes adrenocortical insufficiency in critically ill patients is not clear. Absolute adrenocortical insufficiency (diagnosed by very low plasma cortisol concentrations) is uncommon in the intensive care population. The diagnosis of relative adrenocortical insufficiency (elevated basal plasma cortisol with a subnormal increase in plasma concentrations following an ACTH stimulus) continues to generate debate. The controversy surrounding the role of steroids in sepsis and the confusion over the criteria for diagnosing adrenal insufficiency in the critically ill are reviewed.We suggest that the following caveats be borne in mind when diagnosing adrenal insufficiency in the critically ill patient. Firstly, the gold standard for the diagnosis has not been established. Secondly, caution must be exercised when interpreting a single plasma cortisol value. In the event of a single result indicating adrenal hypofunction, we suggest repeating the measurements after a 6 to 12 hour interval. The clinician must also be aware of variations in cortisol concentrations induced by the assay. Thirdly, the clinician must be aware of the potential limitations of the conventional high dose corticotrophin test. We also suggest that plasma free cortisol is more relevant than total plasma cortisol in the assessment of adrenal function in critical illness and that the low dose corticotrophin test is more sensitive than the conventional high dose test. These areas should be the subject of further investigations.
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2019-20 coronavirus outbreak
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