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    OJ-257 High Serum Gamma-Glutamyl Transferase is a Marker for Clustering of Metabolic Risk Factors in the Japanese General Population(Diabetes / Obesity / Metabolic syndrome(03)(H),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Japanese Circulation Journal-english Edition (2008)
    Toshie SegawaToshiyuki OnodaKazuyoshi ItaiKozo TannoMasaki OhsawaKiyomi SakataKazuko KawamuraFumitaka TanakaKenyu SatohTomohiro TakahashiAkira OkayamaMotoyuki INakamura
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    Presentation (obstetrics)
    Topics:
    Liver Disease Diagnosis and Treatment
    OJ-197 Coronary Plaque Vulnerability in Metabolic Syndrome : Importance of Low HDL-C and Abdominal Obese(Diabetes/Obesity/Metabolic syndrome-2 (H) OJ33,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
    Japanese Circulation Journal-english Edition (2006)
    Masaya KatoKeigo DoteShota SasakiDaiji HasegawaOsamu Matsuda
    Abdominal obesity
    Presentation (obstetrics)
    Vulnerability
    Citations (0)
    OE-338 Order of the Onset of Diabetes Mellitus, Hypertension, and Dyslipidemia in Japanese Males(Diabetes/Obesity/Metabolic syndrome(02)(H),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Japanese Circulation Journal-english Edition (2008)
    Takahisa KondoS. OhsugiKeiko ShimokataHaruo HonjouYukiomi Tsuji
    Dyslipidemia
    Presentation (obstetrics)
    Citations (0)
    OJ-058 Interaction or Disproportionality between Circulating Adiponectin and Leptin is Associated with Elevated C-Reactive Protein in Japanese Men(Preventive medicine/Epidemiology/Education-2 (H) OJ10,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
    Japanese Circulation Journal-english Edition (2006)
    Kaichiro SugiuraHiroshi YatsuyaHirotsugu MitsuhashiKunihiro MatsushitaTakahisa Kondo
    Presentation (obstetrics)
    Citations (0)
    OJ-205 Insulin Resistance Adds Prognostic Information on Clinical Outcome After Acute Myocardial Infarction Among Japanese Patients with and without Glucose Intolerance(Diabetes/Obesity/Metabolic syndrome-04, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Japanese Circulation Journal-english Edition (2007)
    Koichi TamitaAtsushi YamamuroMakoto KajiMinako KatayamaKazuaki Tanabe
    Citations (0)
    OJ-011 Association of Obesity Related Factors with Plasma B-type Natriuretic Peptide Levels in General Japanese Population(OJ02,Obesity/SAS (H),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
    Japanese Circulation Journal-english Edition (2009)
    Takako SugisawaIchiro KishimotoYoshihiro KokuboHisashi MakinoYoshihiro Miyamoto
    Presentation (obstetrics)
    Association (psychology)
    Citations (0)
    Heritability of Multivariate Factors of the Metabolic Syndrome in Nondiabetic Japanese Americans
    Diabetes (2004)
    Melissa A. AustinKaren L. EdwardsMarguerite J. McNeelyWayne L. ChandlerDonna L. Leonetti
    A rapidly growing body of evidence demonstrates important associations between the metabolic syndrome, characterized by a cluster of risk factors or phenotypes that include dyslipidemia, central obesity, hypertension, and hyperinsulinemia, and both cardiovascular disease and type 2 diabetes. The purpose of the present study was to characterize the metabolic syndrome in a sample of 432 individuals from 68 Japanese-American families, using factor analysis of quantitative phenotypes, and to estimate the heritability of these independent factors. Using nine characteristic phenotypes that included LDL particle size and C-reactive protein (CRP), factor analysis identified three multivariate factors interpreted as lipids, body fat/insulin/glucose/CRP, and blood pressure, explaining 65% of the variance. Heritability analysis revealed significant genetic effects on all of the factors: lipids (h(2) = 0.52, P < 0.001), body fat/insulin/glucose/CRP (h(2) = 0.27, P = 0.016), and blood pressure (h(2) = 0.25, P = 0.026). This analysis shows that independent, multivariate factors of the metabolic syndrome are heritable, demonstrating genetic influences on the underlying pathophysiological mechanisms of the syndrome.
    Dyslipidemia
    Hyperinsulinemia
    Citations (81)
    The Metabolic Syndrome in African Americans: a review.
    PubMed (2003)
    Wayne HallLuther T. ClarkNanette K. WengerJackson T WrightShiriki Kumanyika
    The Metabolic Syndrome represents a specific clustering of cardiovascular risk factors. One of several recently proposed definitions encompasses 3 or more of the following 5 abnormalities: waist circumference > 102 cm in men or > 88 cm in women, serum triglyceride level > or = 150 mg/dL, high-density lipoprotein cholesterol level < 40 mg/dL in men or < 50 mg/dL in women, blood pressure (BP) > or = 130/> or = 85 mm Hg and serum glucose > or = 110 mg/dL. The diagnosis of Metabolic Syndrome allows early recognition of an increased risk of cardiovascular disease. African Americans have the highest coronary heart disease mortality of any ethnic group in the United States. African-American women and Hispanic men and women have the highest prevalence of the Metabolic Syndrome. This phenomenon is attributable mainly to the disproportionate occurrence of elevated BP, obesity, and diabetes in African Americans, and the high prevalence of obesity and diabetes in Hispanics. Management of the Metabolic Syndrome consists primarily of modification or reversal of the root causes and direct therapy of the risk factors. The first strategy involves weight reduction and increased physical activity, both of which can improve all components of the syndrome. The second strategy often involves drug treatment of the individual risk factors to further improve BP, lipids, and glucose thereby decreasing the risk of cardiovascular disease. This comprehensive review is provided as part of the educational activities of the African-American Lipid and Cardiovascular Council (AALCC).
    Citations (77)
    PJ-779 Association between Imbalance of Sex Hormone and Acute Coronary Syndrome in Men with Metabolic Syndrome(Diabetes/Obesity/Metabolic syndrome-13, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Japanese Circulation Journal-english Edition (2007)
    Mizuho SumidaAtsushi MotoyamaRyoko SatohHironobu AkaoYasuyuki Kawai
    Citations (0)
    PJ-607 The Effects of Telmisartan in Patients with Metabolic Syndrome(Diabetes/Obesity/Metabolic syndrome-09, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
    Japanese Circulation Journal-english Edition (2007)
    Katsuya MaruyamaYasuo SutaniYoshiteru AbeMasayuki MotohiroSatoshi Tsujimoto
    Telmisartan
    Circulation (fluid dynamics)
    Citations (0)
    PE-067 Comparative Analysis of the Incidence of Metabolic Syndrome among Different Age Groups in the Patients with Coronary Artery Disease(Diabetes/Obesity/Metabolic syndrome(04)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
    Japanese Circulation Journal-english Edition (2008)
    Akihiro NakagomiYoshiyuki SaikiToshiyuki ShibuiYusuke HosokawaMasataka Kamiya
    Citations (0)