-53-ALPHA_1 -ADRENERGIC ACTIVITY REGULATES ADENOSINE RELEASE DURING MYOCARDIAL ISCHEMIA
Masafumi KitakazeMasatsugu HoriYukihiro KoretsuneJun TamaiKunimitsu IwaiKatsuomi IwakuraHiroshi ItoAkira KitabatakeMichihiko TadaMichitoshi InoueTakenobu Kamada
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JapaneseCiiculationSociety 474were divided into 2 grDups in which systolic LVP decreased grenter than 20t o[ that befoie ligatlon (D group} and dtd not (ND group}.Biochemical analysis of sarcoplasmtc rettculum (SR) and measurements of t ±ssue levels of ATP, lactate and pyruvate were performed togethev wtth ultrastructural observation of anyocardial cells in subendo {Endo) and subepicardial muscles (Epi}.In ischemic myocardium Ca-stimulated ATPase activity and major ATPase of SR, and tissue ATP level greatly decreased, accompanied by an increase in lactate as ±n previous reports.In non-ischemic myocardiurn of D group Ca-stimulated ATPase activity reduced significantly to 55 and 5al of those oi in Endo and Epi, respectively, and u]trastructural changes were iound to be Iittle in non-ischemic myocardial cells of D gioup.These results indtcate that metabolie changes take place in non-ischemic myocardium, especia!ly in Endo, underKeywords:
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