Routine laboratory parameters predict serious outcome as well as length of hospital stay in COVID-19
5
Citation
35
Reference
10
Related Paper
Citation Trend
Abstract:
To validate C-reactive protein (CRP), red cell distribution width (RDW), and neutrophil lymphocyte ratio (NLR) for both serious outcomes and length of hospital stay (LOS) among hospitalized coronavirus disease-19 (COVID-19) patients.Laboratory data of adult COVID-19 patients (n=74) was collected in this retrospective cohort. Logistic regression was employed for risk factor evaluation and receiver operating curve was used for comparison of these risk factors for the prediction of serious outcome. Multiple regression was applied to determine the association between routine analytes and LOS.Higher levels of CRP (3 times), white blood cells (20%), and neutrophil counts (40%) were seen in the serious category. Odds ratio for CRP for the serious outcome was 1.052 (p=0.007) and RDW for the serious outcome was 1.218 (p=0.040) in unadjusted model and odds ratio for CRP for the serious outcome was 1.048 (p=0.024) and for RDW 1.286 (p=0.023) in adjusted model. In a multivariate regression analysis for the LOS of the unadjusted models consisting of NLR, monocyte lymphocyte ratio (MLR) and platelet lymphocyte ratio (PLR), the beta coefficients (BC) for the CRP were 0.006 (NLR), 0.005 (MLR) and 0.006 (PLR), whereas -0.029 (NLR), -0.034 (MLR) and -0.027 (PLR) were BCs for mean corpuscular hemoglobin concentration (MCHC). Additionally, in adjusted models, the BCs for MCHC were -0.044 (NLR), -0.047 (MLR) and -0.043 (PLR). However, the CRP was consistent with 0.004 (BC) in all models.We observed that CRP is a better predictor than RDW and NLR for serious outcome among COVID-19 patients. Besides, CRP was positively, whereas MCHC was negatively associated with LOS.Keywords:
White blood cell
Objectives: Objective of this study is to evaluate the association of body mass index with hemoglobin Level, erythrocyte Indices and red cell distribution width in medical students of Baqai Medical University Karachi. Study Design: Descriptive cross - sectional study. Setting: Physiology Department of Baqai Medical University Karachi. Period: 15 February 2017 to 15 August 2017. Material & Methods: A total of 500 students were enrolled in this study. The anthropometric measurement [height (m2) and weight (kg)] was recorded for calculation of the Body Mass Index and Complete blood count i-e Hemoglobin%, erythrocyte indices {Mean corpuscular volume(MCV), Mean corpuscular hemoglobin(MCH), Mean corpuscular hemoglobin concentration (MCHC), Red cell distribution width (RDW) were done and Mentzer’s Index was calculated. Statistical Package for the Social Sciences (SPSS) version 22.0 was used to analyze the collected data. Results: It was observed in 500 medical students that 36% of the students were having low hemoglobin % level, while low values of erythrocyte indices (MCH: 38.0%, MCV 36.6% and MCHC 39.0% respectively) and 93.8% of participants had a higher values of RDW in study participants. Iron deficiency anemia (87.2%) and thalassemia (carrier or minor: 12.8%) were determined by using Menterzer Index. Mean body mass index of study participants were 23.04±3.68 and it was observed in study participants that only RDW was significantly associated with obese students (X²=9.878, p=0.02). Conclusion: With regard to our study results, higher percentage (87.2%) of Iron deficiency anemia were observed and having association between red cell distribution width to obesity.
Mean corpuscular hemoglobin
Cite
Citations (2)
β-Thalassemia (β-thal) and iron deficiency cause most microcytic anemias. Red cell indices and formulas have been established as simple, fast, and inexpensive in discrimination between these two hematological disorders in school children. However, whether these formulas could be applied to diagnose β-thal trait and iron deficiency in adult Thai subjects is unclear. The aim of this study was to examine the diagnostic accuracy of five red cell indices [red blood cell (RBC) counts, mean corpuscular volume (MCV), mean corpuscular hemoglobin (Hb) (MCH), mean corpuscular Hb concentration (MCHC), and red cell distribution width (RDW)] and nine formulas (RDW/RBC, RDW Index, Sirdah, Green and King, Mentzer, England and Fraser, Ehsani, Srivastava and Shine and Lal). Their sensitivity, specificity, positive predictive value (PPV), and negative predictive values (NPV), efficiency, and Youden's Index were analyzed in 102 β-thal trait and 64 iron deficiency adult Thai subjects. The RDW/RBC formula proved to be the most reliable index as they had 100.0% specificity and PPV and the highest efficiency (94.58%) and Youden's Index (91.18%), as well as high sensitivity (91.18%) and NPV (87.67%). Therefore, this formula could be used in initial discrimination of β-thal trait from iron deficiency in adult Thai subjects.
Mean corpuscular hemoglobin
Youden's J statistic
Red Cell
Trait
Cite
Citations (28)
Introduction and Aim: Iron deficiency anemia is the commonest cause of anemia in developing country like India in all age groups. It is most easy to prevent as well as to treat. Its diagnosis and treatment are based on serum ferritin levels in developed countries which is not possible in India at primary healthcare setting. This study was undertaken to explore if red cell indices could replace serum ferritin in detecting iron deficiency.
Materials and Methods: Study of association of red cell indices like Mean Corpuscular Volume (MCV), Mean Corpuscular hemoglobin (MCH), Mean Corpuscular hemoglobin Concentration (MCHC), Red cell Distribution Width (RDW) and Hemoglobin concentration (Hb%) with iron deficiency anemia and the correlation of these Red cell indices and Hb% with serum ferritin was done in 220 anemia patients of all age groups with Hb% <12g/dL.
Results: Descriptive data showed skewed distribution of serum ferritin. Statistically significant reduction in all red cell indices values among iron deficiency anemia patients and statistically significant correlation of all red cell indices values except red cell distribution width with serum ferritin was found.
Conclusion: Unlike developed countries we can use simple estimation of hemoglobin concentration along with red cell indices for diagnosing iron deficiency anemia in primary healthcare setting of India.
Mean corpuscular hemoglobin
Red Cell
Cite
Citations (1)
Objective To investigate the changes of red blood cell volume distribution width (RDW) and its clinical significance in children with malnutritional and anemia.Methods The RDW was detected and analysed in 63 children who were suffered from moderate or severe malnutrition complicated with anemia.The control group included 30 children who were out-patient health examination.The hemoglobin(Hb),red blood count(RBC),mean corpuscular volume (MCV),mean corpuscular hemoglobin(MCH),mean corpuscular hemoglobin concentration(MCHC) and RDW were detected in both groups.Results According to the MCV、MCHC,the children of malnutritional anemia were devided into three types of anemia including macrocytic anemia,normocytic anemia and microcytic anemia.There was no significant difference in RDW among three types of anemia.The RDW in malnutrition group was more significantly elevated than that in control group(P0.01).Conclusion RDW is of great importance in diagnosing malnutritional anemia.
Mean corpuscular hemoglobin
Macrocytic anemia
Complete blood count
Cite
Citations (0)
The Red Cell Distribution width (RDW) which provides a Quantitative measure of heterogeneity of red cells in the peripheral Blood and the mean Corpuscular Volume (MCV) are part of the routine red cell indices reported by automated blood analysis. The study evaluated 250 cases with a wide range of erythrocyte disorders and determined the diagnostic utility of the Red Cell Distribution width (RDW) in relation to the Mean Corpuscular Volume (MCV). Six different groups of erythrocyte disorders by Mean Corpuscular Volume (MCV) and Red Cell Distribution Width (RDW) values are described: Low Mean Corpuscular Volume (MCV)/normal red cell distribution width (RDW), Low Mean Corpuscular Volume (MCV)/High Red Cell distribution width (RDW), normal Mean Corpuscular Volume (MCV)/Normal Red Cell Distribution width (RDW), Normal Mean Corpuscular Volume (MCV)/high Red Cell Distribution width (RDW). High Mean Corpuscular Volume/normal Red Cell Distribution width, High Mean Corpuscular Volume/High Red Cell Distribution width.
Red Cell
Cite
Citations (0)
Objectives: Hemoglobin & red blood cell indices (mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell distribution width) among adolescent. Study Design: Cross-Sectional study (Descriptive). Setting: Department of Physiology, Baqai Medical University (BMU) Karachi. Period: 6 months from February to August 2017. Material & Methods: A total of 500 students of MBBS, BDS, DPT with having age ranges from 18-25 years were enrolled in this study. The anthropometric measurement [height (m2) and weight (kg)] was recorded for calculation of the Body Mass Index and Complete blood count i-e Hemoglobin (Hb%), Mean Corpuscular Volume (MCV), Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC), Red cell distribution width (RDW) was done and calculated. Data analysis was done on Microsoft excel & SPSS version 22.0 was used. Results: It was seen that the comparison of Hb%, MCV & RDW had no significant (p>0.001) association of study participants to different categories of Body Mass Index. Mean corpuscular hemoglobin (MCH) (X²=28.278, p<0.001) and Mean corpuscular hemoglobin concentration (MCHC) (X²=15.659, p=0.016) were statistically significantly association with different categories of Body Mass Index. Conclusion: Mean corpuscular hemoglobin and Mean corpuscular hemoglobin concentration had statistically significant (p<0.001) association with body mass index (BMI).
Mean corpuscular hemoglobin
Cite
Citations (1)
Hematological parameters were measured in 408 blood samples collected over a 30-mo period from 254 captive mountain gazelles (Gazella gazella) in Saudi Arabia. We evaluated the influence of sex, age, capture method, and season, on these parameters. Evaluations also were made with a small number of anesthetized animals. Males had a significantly higher mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) than females. There was no observed neutrophil: lymphocyte ratio shift for either sex during the first months of life. The effects of different capture methods generally were similar in males and females and included a significantly lower MCV and MCH after quick capture. Animals undergoing slow capture had a significantly lower mean corpuscular hemoglobin concentration (MCHC), and very pronounced stress neutrophilia. We propose that this stress neutrophilia caused the permanently high neutrophil: lymphocyte ratio (62:36 average for all gazelles tested) and the lack of a neutrophil: lymphocyte shift in young animals. Erythrocyte counts were significantly higher in summer, while packed cell volume and hemoglobin concentration were the same in summer and winter; thus there was a significantly lower MCV and MCH, and a significantly higher MCHC in summer in both sexes. Fibrinogen varied significantly by sex, age, capture method, and anesthesia.
Neutrophilia
Mean corpuscular hemoglobin
Cite
Citations (34)
The national screening policy for hemoglobinopathies uses the cutoffs for red cell indices mean corpuscular volume >80 and mean corpuscular hemoglobin >27, a strategy known to miss some individuals with Hb E trait (EBT), the most common abnormal hemoglobin in Sri Lanka. We wanted to determine if red cell distribution width (RDW) cutoff values would help in increasing the sensitivity of screening for Hb E trait. High-performance liquid chromatography was carried out as the gold standard to detect hemoglobinopathies and red blood cell parameters with colter counter. Receiver operating characteristic curve was drawn to determine the cutoff value for EBT against β-trait (BTT) and other anemias. Of the 504 patients, 246 had BTT, 110 had EBT, and 151 had other types of anemias. Mean (SD) RDW among patients with BTT was 16 (2.8), with EBT 14.5 (2.9), and with other anemias 15.8 (4.2) (P>0.001). With 14.45 as the cutoff for RDW and considering accepted values for mean corpuscular volume >80 and mean corpuscular hemoglobin >27, it gave a predictive sensitivity of 98.2% for EBT. By using RDW cutoff at 14.45 in addition to the accepted screening indices, sensitivity of Hb E trait detection went up to 98.2% from 86.6%. This study highlights the importance of taking RDW into consideration for screening.
Cut-off
Gold standard (test)
Mean corpuscular hemoglobin
Sickle cell trait
Cite
Citations (4)
Iron deficiency anemia is common problem during pregnancy. Red cell size variation (anisocytosis) is the earliest morphologic changes in iron deficiency anemia. Red cell distribution width is a quantitative measure of red cell size variation and it can give the idea of early iron deficiency before other test to become positive. 190 pregnant women were included in this study. Red cell distribution width was compared between iron deficient & non-iron deficient pregnant women. Red cell distribution width also compared with Hb level, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and peripheral blood film in prelatent iron deficiency, latent iron deficiency, mild and moderate iron deficiency anemia. Red cell distribution width had sensitivity 82.3% and specificity 97.4%. Whereas Hb level, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration and peripheral blood film all had 56.6%, 29.2%, 68.1%, 15% and 38.9% sensitivity but specificity was 90.9%, 98.7%, 83.1%, 96.1% and 98.7% in the detection of iron deficiency. Red cell distribution width appears to be a reliable and useful parameter for detection of iron deficiency during pregnancy.
Mean corpuscular hemoglobin
Anisocytosis
Red Cell
Cite
Citations (26)
Objective: Elevated blood glucose may be affect complete blood count parameters. In this study, we compared the hemogram parameters of healthy individuals and cases with impaired glucose tolerance.
Method: We examineted 134 patients with impaired glucose tolerance and 30 healthy cases. Patients files were evaluated retrospectively and the levels of hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, red blood cell, red cell distribution wide, mean platelet volume, platelet distribution wide, leukocycte, neutrophil, lymphocycte, platelet, and hemoglobin A1c were recorded. Control and patient groups were compared in terms of these parameters with student T test. In addition, the relationship between hemoglobin A1c value and complete blood count parameters were determined in patients with impaired glucose tolerance.
Results: There was no significantly difference between study and control groups in terms of hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, red blood cell count, red cell distrubition wide, leukocycte, neutrophil, lymphocycte, platelet levels. The mean platelet volume and platelet distribution wide values were significantly higher in the patient group than the control group (p value: 0.002, p value: 0.04 respectively).
Conclusion: Complete blood count is an easy, inexpensive test that can be performed in most hospitals. If our study results are supported by other studies, some hemogram parameters may be used to diagnose of impaired glucose tolerance.
Mean corpuscular hemoglobin
Mean platelet volume
Complete blood count
Blood cell
Cite
Citations (0)