Natural Excipients Applications in Conventional Pharmaceutical Formulations -Part I
2
Citation
0
Reference
20
Related Paper
Citation Trend
Abstract:
The form in which drugs are prepared is considered as an important determinant of its bioavailability. In pharmaceutical formulations, excipients offer add-on characteristic properties as integrity, stability, solubility, and patient compliance to those intrinsic properties exhibited by the Active Pharmaceutical Ingredients (APIs). Natural excipients are nowadays gaining a global interest compared to the synthetic ones being nontoxic, biocompatible, less expensive and widely available. This review describes the major conventional pharmaceutical applications of natural excipients.Keywords:
Biocompatible material
Pharmaceutical formulation
Pharmaceutical Sciences
Pharmaceutical technology
Excipient
The objective of a Pharmaceutical Aids development project is to deliver drug to the patient in the required amount, at the required rate, consistently within a batch, from batch to batch, and over the product’s shelf life. To produce a drug substance in a final dosage form requires pharmaceutical ingredients.
Pharmaceutical Aid is all substances contained in a dosage form other than the active substance. They most commonly used dosage form because of the ease of manufacturing; convenience in administration, accurate dosing .In addition, the review will highlight the Pharmaceutical Aid that can be substituted to ensure safety and efficacy of such products such as Excipients.
The current review article is prepared to have a look over the recent development in excipients technology and the approaches involved in development of such excipients. The present review focus on such newer Excipients which have proved their potential in developing efficient solid dosage forms.
Keywords: Excipients, Impurities, ICH, Pharmaceutical substance, Pharmaceutical products, Standardization.
Pharmaceutical drug
Pharmaceutical technology
Pharmaceutical formulation
Pharmaceutical Manufacturing
Cite
Citations (1)
In recent years drug formulation scientists have recognized that single-component excipients do not always provide the requisite performance to allow certain active pharmaceutical ingredients to be formulated or manufactured adequately.In addition to this the cost involved in development of new chemical excipients with improved properties is quite high. In response to these deficiencies, drug formulation scientists have relied on increasing numbers of combination excipients introduced by excipient manufacturers into the commercial market.In order to justify the high rise in new drug development and high industrial output demand, new excipients with purpose satisfying characteristics are the need of the hour.New combinations of existing excipients are an interesting option for improving excipient functionality now-a-days. The current review article is prepared to have a look over the recent development in excipient technology and the approaches involved in development of such excipients. Particle engineering of individual excipients and excipient combinations using coprocessing,by virtue of subparticle modifications,has provided an attractive tool for developing high functionality excipients that are suited to modern tablet manufacturing processes.It signifies the synergistic outcome of the combination of excipients taking their material property into consideration. It also emphasises on the particular material properties in terms of physico-mechanical that are useful to overcome the limitation of existing excipients. All the developed co-processed excipients are enlisted highlighting their multi-functional and beneficial characteristics. Regulatory issues concerned with the development of new excipient as well as coprocessed excipients are also discussed.The future scope determines that coprocessed excipients are the rising need of 21st century.
Excipient
Pharmaceutical technology
Scope (computer science)
Cite
Citations (0)
The use of natural excipients to deliver the bioactive agents has been hampered by the synthetic materials. However advantages offered by these natural excipients are their being non-toxic, less expensive and freely available. The performance of the excipients partly determines the quality of the medicines. The traditional concept of the excipients as any component other than the active substance has undergone a substantial evolution from an inert and cheap vehicle to an essential constituent of the formulation. Gums are widely used natural excipients for conventional and novel dosage forms. With the increasing interest in polymers of natural origin, the pharmaceutical world has compliance to use most of them in the formulations. Since plant polysaccharides comply with many requirements expected of pharmaceutical excipients such as non-toxicity, stability, availability and renewability they are extensively investigated for use in the development of solid oral dosage forms. Furthermore, polysaccharides with varying physicochemical properties can be extracted from plants at relatively low cost and can be chemically modified to suit specific needs. Excipients are any component other than the active substance(s) intentionally added to formulation of a dosage form. This article gives an overview of herbal excipients which are used in conventional dosage forms as well as novel drug delivery systems.
Natural polymers
Excipient
Cite
Citations (7)
The Herbal or natural excipients have great merit over their synthetic analogs as these are non-toxic, low-cost, and freely obtainable. The performance of the excipients partly determines the quality of the medicines. The plant acquired gums, mucilage from the natural origin for example carrageenan, thaumatin, lard, storax, agar, gum acacia, tragacanth, and excipients. They can also be easily altered to meet the specific needs, thereby being a potent many more to name comply with many requirements of the pharmaceutical and economic vehicle for transporting active pharmaceutical ingredients in the formulation. Thus present study aims to throw light on the probable of natural excipients which can be present to be used as a diluent, binder, disintegrant as well as lubricant in different types of formulations as they are biocompatible and capable of giving additional nutrition to the developed dosage form. This article gives an overview of natural excipients which are used in conventional dosage forms as well as novel drug delivery systems.
Tragacanth
Mucilage
Natural materials
Gum acacia
Cite
Citations (3)
Excipient
Pharmaceutical formulation
Cite
Citations (8)
Excipients represent diverse classes of molecules, small molecules or macromolecules, with versatile structures within a given class and are from natural, semi-synthetic and synthetic sources. They are essential ingredients in drug products independently of the route of administration where both traditional and non-traditional uses are present. Beyond their traditional use as formulation and manufacturing aids, certain excipients exhibit biological effects and thus can be used either as atypical active pharmaceutical ingredients alone or synergistically with conventional active pharmaceutical ingredients to affect the overall pharmacokinetics/ pharmacodynamics and therapeutic effect(s) of the co-administered drug(s). In reference to oral drugs, biological effects of the excipients that contribute to improved drug absorption and pharmacokinetics include their ability to modulate drug dissolution, intestinal membrane permeability, gut wall metabolism and efflux pumps. These non-traditional uses of excipients are illustrated in representative case studies from published literature. From a drug development and regulatory perspective, it is apparent that an appropriate excipient classification system is considered which is applied to new uses of existing excipients as well as to the development of novel excipients and segregates biologically active excipients from the larger pool of excipients. This classification system should be a useful tool to pharmaceutical scientists and its successful implementation and broader acceptance requires input and ownership from all major stakeholders, that is, the excipient manufacturers, the end users, excipient forums and discussion groups such as the International Pharmaceutical Excipients Council (IPEC) and regulatory agencies.
Excipient
Cite
Citations (10)
Excipients play an important role in formulating a dosage form. These are the ingredients which along with Active Pharmaceutical Ingredients make up the dosage forms. Excipients act as protective agents, bulking agents and can also be used to improve bioavailability of drugs in some instances, the following review discusses the various types and sources of excipients along with their uses, and these can be used for different activities. Specific excipients are best suited for a particular dosage form; the selection criterion for excipients and various interactions that an excipient can undergo during its course of stay in formulation has been discussed in this review. Some excipient interactions can be detrimental and need to be avoided. This has been detailed out in the interaction section. Excipients as like other active pharmaceutical ingredients need to be stabilized and standardized; the following review gives brief information about standardization and stabilization process alongwith the safety evaluation parameters of the excipients.
Excipient
Pharmaceutical technology
Cite
Citations (76)
Excipients form a major component of pharmaceutical formulations and are classified as any ingredient other than the active ingredient which is included within the product formulation to improve drug product performance. Functional uses of excipients include improving solubility and stability, safety and efficacy, as bulking agents in lyophilized formulations, tonicity agents, and aiding in controlled or prolonged drug delivery. Parenteral formulations are sterile, pyrogen-free; free of particulate matter and by-pass the body's natural defense mechanisms. Excipients may demonstrate a synergistic effect when combined with an active ingredient but may also lead to unwanted reactions with the drugs and packaging components. Ideal excipients are required to be considered safe, inert and multifunctional. Contrary to the past, safety of excipients needs to be well established in order for their use in the pharmaceutical formulations. Therefore, careful consideration should be given while selecting an excipient. This review article provides an overview of the excipients used exclusively in small molecule and biological parenteral products including solutions, suspensions, and lyophilized formulations, information on the possible drug-excipient and drug-packaging interactions and the regulatory requirements for the use of pharmaceutical excipients. The readers will be able to have a comprehensive understanding of the excipients used in parenteral formulations.
Pharmaceutical technology
Cite
Citations (100)
Excipient
Active principle
Active compound
Cite
Citations (3)
Though the utilization of natural excipients to del iver the bioactive agents has been hampered by the synthetic materials, but the added advantages o ffered by these natural excipients are their being non-toxic, less expensive and freely availabl e. The performance of the excipients to some extent determines the quality of the medicines. The traditional concept of the excipients as any constituent other than the active substance has und ergone a substantial evolution from an inert and cheap vehicle to an essential constituent of the fo rmulation. Earlier used natural excipients are carrageenan, thaumatin, lard, shilajit, aerosil, my robalan, storax. Excipients are any component other than the active substances deliberately added to formulation of a dosage form for it proper formulation. Novel drug delivery systems are develo ped to address the challenges of drug development such as bioavailability, permeability, and poor solubility. Global excipients markets are expected to grow rapidly with the emerging tren ds in the pharmaceutical industry. The pharmaceutical industry is marketing refinement in the physical structure of active pharmaceutical ingredients (APIs). The present review would facili tate to comprehend various natural excipients and their role in pharmaceutical products.
Excipient
Cite
Citations (7)