Feasibility evaluation of kilovoltage cone-beam computed tomography dose calculation following scatter correction: investigations of phantom and representative tumor sites
Huipeng MengXiangjuan MengQingtao QiuYanlong ZhangXin MingQifeng LiKeqiang WangRuohui ZhangJinghao Duan
1
Citation
37
Reference
10
Related Paper
Citation Trend
Abstract:
To study the feasibility of kilovoltage cone-beam computed tomography (KV-CBCT) dose calculation following scatter correction.CIRS 062 and Catphan 504 phantoms were used in this study, and 40 randomly selected subjects representing a variety of cases (ten head cancer cases, ten chest cancer cases, ten abdominal cancer cases and ten pelvic cavity cancer cases) were enrolled. We developed in-house software called the cone-beam CT imaging toolkit (CITK) to improve the quality of CBCT images. We first aligned each planning computed tomography (pCT) image with the corresponding CBCT image using rigid registration after scatter correction. Hounsfield unit-relative electron density (HU-RED) calibration was applied to the CBCT images. The pCT plan was then recalculated on CBCT images. Finally, the dosimetric differences between the two plans were evaluated. The dosimetric parameters included the D98, D2, Dmean, conformity index (CI), homogeneity index (HI) and other organ at risk (OAR) dose parameters of the planning target volume (PTV). The dose distribution index (DDI) and the gamma index were also assessed. Paired Student's t-tests or Wilcoxon rank tests were used to evaluate differences. P<0.05 was considered significant.In the phantom and patient cases, the average dosimetric difference was less than 1% in the PTV and OARs. There was no significant difference in the CI or HI between the two plans. The gamma pass rate of 2%/2 mm was greater than 95% in both plans. There was a significant difference in the DDI between the two plans in the chest group but not in the other groups.The results suggest that CBCT has high accuracy in dose calculation via scatter correction and HU-RED calibration.Keywords:
Hounsfield scale
Image-guided radiation therapy
Cone-Beam CT
Image-guided radiation therapy
Cone-Beam CT
Cite
Citations (0)
Image-guided radiation therapy
Cone-Beam CT
Cite
Citations (0)
Image-guided radiation therapy
Cone-Beam CT
Cite
Citations (0)
Bisphosphonate-induced osteonecrosis of the jaw (BONJ) is a frequently reported complication. The aim of this study was to investigate the clinical and histopathological presentation of BONJ with the Hounsfield score and to evaluate the reliability of the score for determining necrosis in an animal model.Eighty rats were prospectively and randomly divided into two groups of 40 each: a control group and an experimental group. Half of the animals from each group underwent extraction of the left mandibular molars, and the other half underwent extraction of the left maxillary molars under pentobarbital-induced general anesthesia. All animals were euthanized 28 days after tooth extraction. Maxillae and mandibles were extracted, cone beam computed tomography (CBCT) was performed, and Hounsfield scores were evaluated.The Hounsfield scores of the experimental group were found to be compatible with chronic osteomyelitis and periosteal reactions. The Hounsfield scores of the control group were compatible with a healthy healing period.In light of these results, both cone beam computed tomography (CBCT) and the Hounsfield Units (HU) evaluations together are thought to be efficient in the diagnosis of BONJ.
Hounsfield scale
Cite
Citations (33)
Image-guided radiation therapy
Cone-Beam CT
Cite
Citations (0)
A comprehensive artefact correction method for clinical cone beam CT (CBCT) images acquired for image guided radiation therapy (IGRT) on a commercial system is presented. The method is demonstrated to reduce artefacts and recover CT-like Hounsfield units (HU) in reconstructed CBCT images of five lung cancer patients.
Hounsfield scale
Thorax (insect anatomy)
Cone-Beam CT
Image-guided radiation therapy
Cite
Citations (44)
Hounsfield scale
Cite
Citations (64)
Image-guided radiation therapy
Cone-Beam CT
Cite
Citations (1)
The aim of this study is to evaluate two different Image Guided RadioTherapy (IGRT) methods during 38 fractions of one prostate cancer patient's treatment.Prostate cancer patient was scanned 3.0mm width by Siemens Biograph mCT and Elekta Clarity ® Ultrasound system with transabdominal probe.Critical organs and targets were determined from fusion of these images on the CT data set.Volumetric modulated arc therapy (VMAT) planning were performed by using Monaco 5.1 ® treatment planning system.Reference images of CT scan and ultrasound images were sent to Elekta Versa HD ® linear accelerator's treatment system.Before the prostate cancer patient's treatment, we had scanned prostate localization by Elekta Clarity ® Ultrasound system.Then we compared ultrasound images with reference images and we adjusted position of couch.For checking the localization of prostate, we scanned patient by XVI 4.5 Cone Beam CT system and we determined the difference between Ultrasound scan and Cone Beam CT scan an average 2.8±1.6mmlateral direction, 2.9±1.1mmlongitudinal direction and 2.6±1.4mmvertical direction during 38 fractions of treatment.The results show that comparison between Clarity ® Ultrasound system and Cone Beam CT system less than 3.0mm in three directions.Therefore, we are treating prostate cancer patient with ultrasound IGRT method instead of Cone Beam CT scan method in our clinic.
Image-guided radiation therapy
Cone-Beam CT
Cite
Citations (1)
Image-guided radiation therapy
Cone-Beam CT
Cite
Citations (3)