DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France
Maria Pia SormaniMarco SalvettiPierre LabaugeIrene SchiavettiHélène ZéphirLuca CarmiscianoCaroline BensaNicola De RossiJean PelletierCinzia CordioliSandra VukusicLucia MoiolaPhilippe KerschenMarta RadaelliMarie ThéaudinPaolo ImmovilliOlivier CasezMarco CapobiancoJonathan CironMaria TrojanoBruno StankoffAlain CréangeGioacchino TedeschiPierre ClavelouGıancarlo ComıÉric ThouvenotMario Alberto BattagliaThibault MoreauFrancesco Pattide SèzeCéline Louapre
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Abstract:
Abstract We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti‐CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid‐19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled‐analysis confirms an increased risk of severe Covid‐19 in patients on anti‐CD20 therapies and supports the protective role of interferon.Keywords:
Pooled analysis
2019-20 coronavirus outbreak
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Alles auf einen Blick: Auf der Webseite der DRG erhalten Sie aktuelle Informationen der Radiologie zur SARS-CoV-2-Pandemie. Dort finden Sie beispielsweise Empfehlungen für die radiologische Versorgung oder zur unterstützenden Diagnostik durch die CT.
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