Fatty Liver Disease Prediction Using Supervised Learning
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Keywords:
Liver disease
Alcoholic fatty liver
Steatosis
Creatine
Liver disease
Liquid diet
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Background: The correlations between alcohol consumption and cirrhosis of liver have been dealt with great detail. As with the many studies that have looked upon the mortality of the patients with cirrhosis, the speed of progression of the disease and the various situations in which the condition of the patient deteriorates, many have been inconclusive about the reason for death in patients of cirrhosis of liver as the disease progresses.Methods: This study was conducted in the department of medicine, Vijayanagara Institute of Medical Sciences, a tertiary care hospital in Bellary, Karnataka Study subjects: were a group of 50 patients with alcoholic cirrhosis, a group of 50 patients with non-alcoholic cirrhosis and 50 normal subjects without cirrhosis.Results: The ECG findings among alcoholics, low voltage complex 10%, long QT3% LAE 8% LVH16%. ST T changes 10%. Among non-alcoholic patients low voltage complex 4% Long QT 2% LAE 7%, LVH 16% ST T changes 16%.Conclusions: The cardiovascular abnormalities did not show much difference between the alcoholic and non-alcoholic patients.
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There is a worldwide tendency towards a reduction in the rates of deaths due to cirrhosis. In Chile, a decrease in the number of hospital admissions due to this disease has been recorded.To assess general characteristics and temporal evolution of liver cirrhosis mortality in Chile between 1990 and 2007.National death records and population databases were reviewed. Crude and age-adjusted mortality rates for alcoholic and non-alcoholic cirrhosis were calculated, evaluating their evolution in the study period and the relative risk by gender.In the study period, 44,894 deaths caused by cirrhosis were recorded. Mortality rate was 16.6 deaths per 100,000 inhabitants. 54% of deaths were attributed to non-alcoholic cirrhosis. There was a reduction in mortality rates for both types of cirrhosis. Males accounted for 83 and 65% of deaths caused by alcoholic and non-alcoholic cirrhosis, respectively. The figures for relative risk of death were 5 and 1.9, respectively.Alcoholic cirrhosis was the preponderant cause among liver cirrhosis deaths. A decrease in mortality rates was observed in the study period. Improvements in disease treatment and control could possibly explain this trend.
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Objective To determine the AST/ALT ratio in healthy control,chronic hepatitis (G 0～3) and hepatic cirrhosis, and evaluate the relationship of AST/ALT ratio and hepatic cirrhosis. Method The levels of AST and ALT of healthy control group, patients with chronic hepatitis (G 0～3) and patients with hepatic cirrhosis were determined by Olympus AU640 automatic biochemical analyzer. Results There was no statistically significance difference between the AST/ALT ratios of healthy control group and patients with chronic hepatitis of different phases (G 0～3,P0.05), but there was statistically significance diference between healthy control group and patients with hepatic cirrhosis(P0.01). The difference was increasing with the increase in the class of Child-Pugh classification (P0.01).Correlation analysis demonstrated that the AST/ALT ratio of patients with hepatic cirrhosis has positive correlation with the child-Pugh integral (r=0.656,P0.01). There was statistically significance between the AST/ALT ratios of patients with chronic hepatitis (G 0～3) and patients with hepatic cirrhosis (P0.01). There was statistically significance difference between AST/ALT ratios of living and dead patients with hepatic cirrhosis (P0.05). There was statistically significance difference between AST/ALT ratios of hepatic cirrhosis patients with and without upper gastrointestinal bleeding (P0.05). Conclusion The AST/ALT ratios of patients with hepatic cirrhosis can be used as a indicator of the condition of patients with hepatic cirrhosis, and for prognosis judgement.
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Alcoholic Hepatitis
Liver disease
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SummaryThe purpose was to study the features of clinical and laboratory manifestations ofalcoholic liver disease at the cirrhosis stage associated with non-alcoholic fatty liverdisease.Material and methods. Clinical, laboratory and instrumental examinations wereperformed for 204 patients with hepatic cirrhosis. 78 persons had alcoholic liver disease(Group I) and 126 persons had a combination of alcoholic liver disease with nonalcoholic fatty liver disease (Group II). Group I included 24 women and 54 men(53.2±7.6) years old; 22 women and 104 men (47.8±6.4) years old belonged to GroupII. Patients of Groups I and II were allocated to subgroups according to the classes ofhepatic cirrhosis compensation according to the Child-Pugh criteria: IA (17 patients),IB (38 patients), IC (23 patients); IIA (44 patients), ІІВ (48 patients), ІІС (34 patients).Results and discussion. It was found that the signs of astheno-vegetative, pain,dyspeptic, hepatorenal, hepatopulmonary syndromes, jaundice, medically uncontrolledascites, and manifestations of hepatic encephalopathy were shown more often amongpatients in combination with non-alcoholic fatty liver disease. Somatometric indicessignificantly differed among all patients depending on the degree of compensation. Thethickness of the skin and fat fold are reliable indicators that reflect the state of the fatdepot of the body; the circumference of shoulder muscles is a reliable indicator of thereduction of the somatic protein pool, accompanied by a decrease in the syntheticfunction of the liver and a decrease in the somatic protein pool, especially amongpatients associated with non-alcoholic fatty liver disease.Conclusions. During examining patients with liver cirrhosis, the study of the trophicstatus, synthetic function, and functional state of the liver are recommended for timelycorrection of the revealed disorders.
Alcoholic fatty liver
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Context: Alcoholic liver cirrhosis is a significant risk factor for the development of hepatocellular carcinoma (HCC). The importance of tumour-associated cirrhosis in the development or progression of HCC is not understood. MiRNAs are important regulators for HCC development, but their role in HCC due to alcoholic liver cirrhosis is unclear.Objective: The aim of this study is the detection of miRNA expression in alcoholic liver cirrhosis, tumour-associated cirrhosis, and HCC.Materials and methods: We analysed the differences in the miRNA profiles of HCC, tumour-associated cirrhosis, and cirrhosis without HCC samples from 30 patients who underwent liver transplantation because of alcoholic liver disease.Results: Microarray analyses revealed 40 significantly differentially expressed miRNAs between HCC tissue and tumour-associated cirrhosis tissue. Furthermore, the microarray analysis discovered 56 differentially expressed miRNAs in tumour-associated cirrhosis and cirrhosis without HCC.Discussion: The differences of miRNA profile in alcoholic liver cirrhosis with and without HCC could improve understanding of HCC development, as well as lead to a new diagnostic tool in HCC screening.Conclusion: We were able to show for the first time, the differences of miRNA profile as promising biomarker in HCC, tumour-associated cirrhosis, and cirrhosis without HCC in context of alcoholic liver disease.
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Two hundred seventy-one patients with various forms of alcoholic liver disease were followed up for an average of 87.9 months. The survival was the lowest for alcoholic cirrhosis (average 10-year survival: 23.8%). Prognosis was grave especially in cirrhotic patients who continued drinking, owing mainly to the increased death due to gastrointestinal bleeding. The development of hepatocellular carcinoma (HCC) was observed during the first six years only in cirrhosis. The average 5-year probability rate of developing HCC for cirrhosis was 16.3%. The rate was significantly higher for the cirrhotic patients who abstained than for those who continued drinking. Serial biopsies were performed on 66 non-cirrhotic patients who continued drinking. The mean duration of histological follow-up 46.0 months. Cirrhosis developed eventually in 30.3% of the cases. In conclusion, the present study indicates that continued drinking causes progressive liver damage and a poor prognosis. Our data also suggest that abstinence is associated with an increased risk of HCC in cirrhosis. Thus, it is important to recover from alcoholism before cirrhosis develops.
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