Improvement of dispersibility by casein modification in Ca 10 (PO 4 ) 6 (OH) 2 :Mn 5+ nanoparticles for fluorescent bioimaging
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Nanomedicine covers the application of nanotechnologies in medicine. Of particular interest is the setup of highly-cytocompatible nanoparticles for use as drug carriers and/or for medical imaging. In this context, luminescent nanoparticles are appealing nanodevices with great potential for imaging of tumor or other targetable cells, and several strategies are under investigation. Biomimetic apatite nanoparticles represent candidates of choice in nanomedicine due to their high intrinsic biocompatibility and to the highly accommodative properties of the apatite structure, allowing many ionic substitutions. In this work, the preparation of biomimetic (bone-like) citrate-coated carbonated apatite nanoparticles doped with europium ions is explored using the citrate-based thermal decomplexing approach. The technique allows the preparation of the single apatitic phase with nanosized dimensions only at Eu
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hydroxyapatite (幸运) 和铈的 Nanoparticles 与 Ce/ 的原子比率代替了 hydroxyapatite (CeHAP )[Ca + Ce ](xCe ) 被弄干的 sol-gel-supercritical 液体(SCFD ) 从 0 ～ 0.2 准备方法。nanoparticles 被 TEM， XRD，和英尺红外描绘，并且晶体结构，结晶度，和粒子形状上的铈的效果被讨论。与细菌的抑制地区和抗菌剂比率的测试， Escherichia 关口 i，上的幸运和 CeHAP nanoparticles 的抗菌剂性质葡萄球菌 aureus，乳杆菌被研究。结果证明幸运和 CeHAP 的 nanoparticles 能被 sol-gel-SCFD 做，铈能部分代替钙并且进入幸运的结构。在替换以后，结晶度，在 CeHAP 的契约的 IR 波浪数字随从短条形的幸运改变到塑造针的 CeHAP 的 nanoparticles 的铈替换，和形态学的增加逐渐地减少了。有低于 0.08 的 xCe 的幸运和 CeHAP 的 nanoparticles 仅仅强制地有抗菌剂性质在 0.1 g ml 的测试集中与测试细菌联系(? 1 )，然而 CeHAP nanoparticles 在那集中有抗菌剂能力静态地或动态地不管当 xCe 超过 0.08 时，与测试细菌联系，并且抗菌剂能力随 xCe 的增加变得更好，在钙是以后，显示抗菌剂性质被改进部分由铈代替了。乳杆菌上的 CeHAP nanoparticle 的改进抗菌剂效果显示出它的潜在的能力到反龋。
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Nanocomposite hydroxyapatite-silver was synthesized using glucose, glycerol and hydrazine chloride as the reductant. Glucose and glycerol promote the formation of 22-25 nm silver nanoparticles on the surface of hydroxyapatite (HA), forming a composite, characterized by intense absorption. One nanoparticle of silver is connected with every particle of HA. Sodium citrate effectively stabilizes this nanocomposite. When using hydrazine hydrochloride as a reducing agent of Ag + ions clusters and small silver nanoparticles (NPs), which are not distinguishable by TEM images, are formed on the surface of hydroxyapatite. This nanocomposite possesses less intense absorption.
Hydrazine (antidepressant)
Silver nanoparticle
Reducing agent
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Shiny, HAp(py) crystals: Luminescent, colloidal, F-substituted, hydroxyapatite (FHAp) nanocrystals have been synthesized by rare-earth-ion doping, which showed green emission in solutions and films and red emission in a polymer matrix. Due to the wide availability and excellent mechanical and biologically compatible properties, these luminescent nanocrystals may find applications in biological labeling, luminescent polymers, and so forth. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Highly biocompatible multifunctional nanocomposites consisting of monodisperse manganese oxide nanoparticles with luminescent silica shells were synthesized by a combination of w/o-microemulsion techniques and common sol–gel procedures. The nanoparticles were characterized by TEM analysis, powder XRD, SQUID magnetometry, FT-IR, UV/vis and fluorescence spectroscopy and dynamic light scattering. Due to the presence of hydrophilic poly(ethylene glycol) (PEG) chains on the SiO2 surface, the nanocomposites are highly soluble and stable in various aqueous solutions, including physiological saline, buffer solutions and human blood serum. The average number of surface amino groups available for ligand binding on the particles was determined using a colorimetric assay with fluorescein isothiocyanate (FITC). This quantification is crucial for the drug loading capacity of the nanoparticles. SiO2 encapsulated MnO@SiO2 nanoparticles were less prone to Mn-leaching compared to nanoparticles coated with a conventional bi-functional dopamine–PEG ligand. The presence of a silica shell did not change the magnetic properties significantly, and therefore, the MnO@SiO2 nanocomposite particles showed a T1 contrast with relaxivity values comparable to those of PEGylated MnO nanoparticles. The cytotoxicity of the MnO@SiO2–PEG/NH2 nanoparticles was evaluated using primary cells of the innate immune system with bone marrow-derived polymorphonuclear neutrophils (BM-PMNs) as import phagocytes in the first line of defence against microbial pathogens, and bone marrow-derived dendritic cells (BMDCs), major regulators of the adaptive immunity. MnO@SiO2–PEG/NH2 nanoparticles have an acceptable toxicity profile and do not interact with BMDCs as shown by the lack of activation and uptake.
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