Impact of the harsh Antarctic environment on mucosal immunity
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Abstract Mucosal immunity of Indian Antarctic personnel was analysed during the 34th Indian Scientific Expedition to Antarctica (ISEA) by ship voyage. Serum and salivary IgA, IgA1 and IgA2 levels along with salivary cortisol and TGF-β were quantified by enzyme-linked immunosorbent assay. Samples were collected at three different time points (T1, T2 and T3) during the expedition. Serum and salivary IgA, IgA1 and IgA2 concentrations incrementally increased towards the end of the expedition as compared to the beginning of the expedition. Salivary IgA and TGF-β levels were significantly altered during the expedition. Levels of IgA1 ( P = 0.0007) and IgA2 ( P = 0.0135) increased significantly at T3 as compared to T1. Additionally, significant changes in serum IgA were observed, with peak levels at T3 ( P = 0.0015) and T2 ( P < 0.001). However, the level of serum IgA2 was also significantly altered at T3 ( P < 0.05) and T2 ( P = 0.0006) in comparison with T1. The exact cause of the changes in serum and salivary IgA, IgA1, IgA2 and TGF-β levels during the summer expedition are unknown; however, the changes are evident in mucosal immunity.Keywords:
Mucosal Immunity
Immunoglobulin A
Prof. IP Voloshin (West. Rhinolaryngo-otiatry. 1925, No. 1), taking into account the well-known works of Bezredk on local immunity, finds that the protective role of the nasal mucosa and upper respiratory tract is reduced to the development of natural local immunity of these organs than the general immunity of the whole organism is acquired from all microorganisms inhabiting the mucous membrane of these pathways.
Mucous membrane
Respiratory tract
Mucosal Immunity
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Immunoglobulin A
Serum Albumin
Human serum albumin
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The experiment was conducted to study the mensuration of IgG content in chickens′ mucosal immune system after Lasota vaccination. The changes of HI titer in immunized chickens′ tear, tracheal fluid and serum were measured in the experiment. The results showed that when mucosal immunity in NDV immunity is used, the IgG content of mucosal immune response positions is higher than that when humoral immunity is used; After the mucosal immunity, the stronger immune response is produced near the immunized position; HI titer in mucosal immune positions is higher than that in serum after the first immunity, but the result is reversed after the second immunity.
Newcastle Disease
Mucosal Immunity
Humoral immunity
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Mucosal immunity covers a variety of mucosal surfaces susceptible to different pathogens.This review explores the basic principles of mucosal immunity in light of the diversity of mucosal surfaces and their unique tissue environments,and offers some thoughts on approaches for developing vaccines to induce mucosal immunity,predominantly based on experiments studying immune responses to infection and vaccination in large animals.
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Mucous membrane; Immunity,mucosal; Vaccines
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Mucous membrane
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The research showed that the instestinal tract was the biggest immune organ in human body.More and more attention had been paid to the injury of intestinal immunity caused by sport and its treatment.The paper expatiated on the researches of relations between the glutamine and intestinal immunity,between sport and intestinal immunity and between the glutamine supplement and gut immunity.
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Digestive tract
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Effect of E.coli on intestinal mucosal immunity-associated cells of rabbits was studied,and the curative effect was compared by intestinal mucosal immunity,forty rabbits were randomly divided into four groups.At different times mucosal immunity-associated cells were observed after injection of E.coli by abdominal cavity.The results showed that the number of mucosal immunity-associated cells was increased after intraperitoneal injection of bacilli,intestinal mucosal immunity was stimulated.There were no differences among cidomycin,lactolin and control groups or cidomycin and lactolin groups,better treatment effect was made.
Mucosal Immunity
Abdominal cavity
Intraperitoneal injection
Intestinal mucosa
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This study determined the concentration of salivary immunoglobulin A (salivary IgA) in saliva from labial and buccal minor glands of children, adolescents, and adults. According to previous studies minor glands produce about 35% of total salivary IgA. Age-dependent increase in whole-saliva salivary IgA concentrations has been studied extensively, but we found no reports comparing minor-gland saliva concentrations of salivary IgA in children, adolescents, and adults. Three age groups donated saliva for analysis: 3-yr-olds (n = 28), 14-yr-olds (n = 27), and 20 to 25-yr-olds (n = 26). Minor-gland saliva was collected on filter paper and unstimulated whole saliva by draining into a tube and salivary IgA concentration was determined by ELISA. Salivary IgA concentration in labial saliva was significantly lower (P < 0.01) among 3-yr-olds (3.7 mg 100 ml-1, SD 3.5) compared to 14-yr-olds (12.6 mg 100ml-1, SD 12.8) and adults (12.8 mg 100ml-1, SD 13.4). The 3-yr-olds also had significantly lower (P < 0.05) whole-saliva salivary IgA values compared to the other age groups (9.0 mg 100ml-1, SD 9.1; 17.9 mg 100ml-1, SD 14.9; and 17.0 mg 100ml-1, SD 9.9, respectively). This increase in salivary IgA concentrations with age might reflect a developing immune response in the growing child
Immunoglobulin A
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Mucosal Immunity
Mucosal immunology
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Immunoglobulin A (IgA) is the principal immunoglobulin in human saliva and minor salivary glands contribute with approximately 30-35 % of the total salivary IgA in whole saliva. Salivary IgA is con ...
Immunoglobulin A
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