Targeted antitumor comparison study between dopamine self-polymerization and traditional synthesis for nanoparticle surface modification in drug delivery
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To improve the therapeutic efficacy of anticancer agents and extend their application, mussel-inspired chemical modifications have attracted considerable attention. Surface modification based on polydopamine (PDA) has been a facile and versatile method to immobilize biomolecules on substrates for targeted drug delivery. To better analyze pharmaceutical differences between PDA-based surface modification and traditional synthesis methods, we prepared two kinds of folate (FA)-targeted nanoparticles (NPs) loaded with paclitaxel (PTX). The resultant PTX-PDA-FA NPs and PTX-FA NPs represented PDA and synthesis strategies, respectively. PTX-PDA-FA NPs and PTX-FA NPs have been characterized. The particle size of PTX-PDA-FA NPs was smaller than that of PTX-FA NPs. The two kinds of NPs both exhibited long-rod morphology, good colloidal stability and sustained slow drug release. Cytotoxicityin vitrowas evaluated, and antitumor efficacy was investigated against 4T1 tumor-bearing mice. The tumor targeting therapeutic index of PTX-PDA-FA NPs and PTX-FA NPs showed equivalent superior specificity compared to nontargeted groups, which indicated that FA successfully attached to the surface of NPs by the PDA method and that the antitumor effect was equivalent to that of FA-modified NPs prepared by the chemical synthesis method. These results further indicated that PDA, as a simple and effective chemical surface modification platform, could be developed and applied in targeted delivery systems.Keywords:
Surface Modification
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Colon targeted drug delivery system (CTDDS) delivered as both local and systemic delivery of drugs. Local delivery could, for example, allow topical treatment of inflammatory bowel disease (IBD). Treatment could be enhanced when drug delivered to the target site on the colon. Systemic side effects could also be reduced. Colon specific systems is most important delivery of those drug which are normally inactivated in the upper parts of the gastrointestinal tract (GIT). Primary approaches for CTDDS (Colon targeted Drug Delivery System), which includes prodrugs, pH and time dependent systems, Bacterial enzyme dependent colonic DDS and pH and bacterial enzyme dependent colonic DDS. The novel approach of CTDDS, which includes pressure controlled colonic delivery capsules (PCDCS), CODES and osmotic controlled drug delivery are specific technique.
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Targeted drug delivery
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Oral colon targeted drug delivery system can be divided into pH dependent, time-dependent, enzymatic degradation etc. according to the ways of drug delivery. Mechanism of drug delivery, preparation method and application of oral colon targeted drug delivery system were introduced. In addition, it previewed the research direction of colon targeted drug delivery in the future, to provide a reference for the targeted new dosage form.
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Targeted delivery combined with controlled drug release has a pivotal function in the future of personalized medicine. Target drug delivery system is one of the most considerable novel approach towards drug delivery system. Targated drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of the medication in the ultimate tissues thus enhancing therapeutic index and bioavailability at site specific-delivery .Now a days various carrier systems which includes liposomes, niosomes, aquasomes,pharmacosomes, dendrimers, nanoparticles, microspheres, solid lipid nanoparticles, resealed erythrocytes etc. are utilized in target drug delivery system which provide site specific drug delivery. Drug targeting is the principle by which the distribution of drug in organism is maneuverer in manner such that its major fraction interacts exclusively with the target tissue at the cellular and subcellular. The present review deals with the Targeted drug delivery system its advantages, disadvantages, need of Targeted drug delivery system, Types, drug targeted to a specific organ such as Brain, kidney, heart, colon and respiratory tract and research update on Targeted drug delivery system. Various drug carriers which can be used in this advance delivery system are Niosomes, Liposomes, Nanoparticles, Monoclonal Antibodies.
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In field of medicine oral route is mostly used path for the administration of drug. so, the oral route is not preferred for lower GIT disorder. So, to overcome this problem drug directly targeting to the specific site. In this review article overview on the colon targeting drug delivery system. Colon is the site where drug is targeted on the local site and used for the local colon disease. Colon targeting drug delivery system not just for the local disease but also used for the systemic delivery of the drug such as proteins, therapeutic peptides, anti-asthmatic, anti-hypertensive drug, antidiabetic drug. Now a day number of method are used to formulate CTDDS such as formation of pro drug, coating of polymers etc. colon targeting drug delivery system is a new system for targeting a drug in specific site for enhance the therapeutic effect of poorly absorbed drug. And now a day drug targeted on colon through rectal route. But this route is very painful. In this article discuss about the anatomy of the colon, factor affecting the colon targeting drug delivery system, advantages of colon targeting drug delivery system, limitation of colon targeting drug delivery system and evaluation of the colon targeting drug delivery system. But in this review mainly discuss about the new method used for colon targeting drug delivery system such as Microspheres,carbon nanotube, metal nanoparticles etc
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Paclitaxel is an important anticancer drug, which is used for treatment of ovarian, breast and lung cancer. The paclitaxel treatment shows two main limitations – poor water solubility of the drug and lack of tumor-specificity. Conjugation of paclitaxel with specific targeting compounds might improve its effectivity and decrease undesirable side effects. This review resumes the research results in the last ten years. Many targeted conjugates of paclitaxel were developed, folic acid, hyaluronic acid, monoclonal antibodies, hormones, fatty acids and glucose being used as tumor-targeting moieties in the conjugates. The conjugates were tested for cytotoxicity; many of them possess a better anticancer activity than free paclitaxel. The targeted delivery of paclitaxel to cancer cells is a potential promising chemotherapy.
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In the last two decades colon targeted drug delivery has gained increased importance not just for the deliver drugs for the treatment of various colonic diseases but also for its potential for delivery of proteins and therapeutic peptides. In the past various traditional approaches used for colon targeted delivery like prodrugs, pH, time dependent, and microflora activated systems, have achieved limited success. For successful colon targeted drug delivery, the drug needs to be protected from absorption and/or the environment of the upper gastrointestinal tract and then be abruptly released into the colon. Hence continuous efforts have been made on designing colon targeted drug delivery systems with improved site specificity and versatile drug release kinetics to fulfill different therapeutic needs. In last couple of years few new systems have been developed for colon targeted drug delivery such as pressure dependent systems, CODES™ technology, micrsponges, pectin and galactomannan coating, microbially triggered osmotic systems, lectins and neoglyconjugated etc. which are reported to have better in-vivo site specificity and design rationale than the earlier approaches. This review article gives an overview of various approaches for colonic targeted drug delivery with emphasis on newer systems, their merits and demerits, in vitro/ in-vivo evaluation and market status of such delivery systems. Keywords: Colon targeted, microflora activated, prodrugs, lectin and neoglyconjugates, microsponges, CODES ™ technology
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Since the discovery of nanomedicine-based drug delivery carriers such as nanoparticles, liposomes, and self-nanoemulsifying drug delivery systems (SNEDDS), enormous progress has been achieved in the field of innovative active biomolecule drug delivery systems [...].
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