Computed tomography identified mineralisation of the longitudinal odontoid ligament of the horse is associated with age and sex but not with the clinical sign of head shaking
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Abstract Mineralisation of the longitudinal odontoid ligament has recently been identified in three horses undergoing computed tomographic (CT) examination, but published studies describing the clinical relevance of this finding are currently lacking. The objective of this retrospective, analytical, cross‐sectional study was to investigate the relationship of this image finding to primary presenting complaint, age, breed, use and sex of the patient, and determine any association to the clinical signs of head shaking, neck pain or restricted range of neck motion. Computed tomographic images of 96 horses undergoing examination of the head and cranial cervical spine, for a variety of clinical reasons, were assessed for the presence of mineralisation within the longitudinal odontoid ligament. Clinical records were reviewed; presenting problem, signalment, clinical signs and final diagnoses were recorded and potential associations of presenting primary problem, signalment and individual clinical signs with mineralisation in the longitudinal odontoid ligament investigated, using univariable and multivariable ordinal logistic regression analysis. Final multivariable analysis confirmed significant associations of increasing severity of mineralisation with increasing age ( P = .002) and being female ( P = .038). There was no association of mineralisation of the longitudinal odontoid ligament with the syndrome of idiopathic head shaking or other clinical signs investigated in this sample of horses. Authors therefore recommend that the clinical significance of mineralisation of the longitudinal odontoid ligament be interpreted cautiously for equine CT studies.Keywords:
Clinical Significance
Neck pain
Longitudinal Study
lsacsetup creates a longitudinal dataset for Growing Up in Australia: The Longitudinal Study of Australian Children (LSAC), Australia's flagship birth cohort study, using a single line of Stata code. LSAC data are disseminated as a collection of cross-sectional files which need to be combined by the user. The command lsacsetup is designed to substantially simplify and speed up the process of combining the information in LSAC into a single analytic dataset in long format. lsacsetup supports variables contained in the LSAC longitudinal files (e.g. lsacgrb0), the household files (e.g. plegrhhb), and the NAPLAN files (e.g. lsacnaplanacara_gr) featured in the general release of LSAC. Users are required to specify the directories in which the original data is located and where the new file will be stored; the variables in the longitudinal LSAC files that are required; the preferred name for the longitudinal dataset to be created; and the data release used. Additionally, users have the option to specify whether they require any variables from the household or NAPLAN data files, and whether they wish to use information from LSAC's between-wave questionnaires (a.k.a. waves 2.5 and 3.5). lsacsetup currently supports only the general release of LSAC and does not handle variables from the PLE, TUD or Medicare data files.
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Background Incidental findings (IFs) are commonly seen in staging rectal magnetic resonance imaging (MRI) scans. Their prevalence and clinical significance have not been previously documented. Purpose To assess the prevalence, clinical significance, and outcomes of incidental findings in MRI scans performed for the staging of rectal cancer. Material and Methods A retrospective study was performed at a tertiary colorectal imaging institution. Consecutive MRI rectal staging scans with correlative pathology confirmed primary rectal cancer between March 2014 and March 2021 were identified. The respective imaging reports were reviewed for IFs, which were classified as high, moderate, and low, according to their clinical significance. Medical records were reviewed to assess the outcomes of the highly significant IFs. Results There were 266 eligible patients (97 women; mean age = 64.2 years) during the study period. A total of 120 (45%) patients did not have any IFs. A total of 238 IFs in 146 (55%) patients were found. There were 21 (9%) IFs of high clinical significance, 122 (51%) of moderate clinical significance, and 95 (40%) of low clinical significance. The prostate and uterus had the most IFs of high clinical significance, two of which were subsequently pathology confirmed as prostate adenocarcinomas. Conclusion IFs were seen in more than half of the staging MRI scans in rectal cancer but less than 10% of these were of high clinical significance. The results of this study highlight the range of potential IFs and can guide future research assessing the potential impact of these IFs on patients and the healthcare system.
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Neck pain
Laminoplasty
Etiology
Referred pain
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Objective To compare the efficacy of ligament repair method and ligament reconstruction method for repture of collateral ligament of proximal interphalangeal joint. Method 50 cases(58 fingers) with collateral ligament damage were treated as fallows: ligament reconstruction using palmaris longus tendon in 31 fingers and ligament repair in 27 fingers from 2003 to 2006.The follow-up period was 1~3 years.Results According to Saetta criteria,the excellent and good rate of ligament reconstruction and ligament repair was(93.5)% and 66.7% respectively(χ2=10.45,P0.05).Conclusion Ligament reconstruction was better than ligament repair in the treatment of rupture of collateral ligament of proximal interphalangeal joint.
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Medial collateral ligament
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The China Health and Retirement Longitudinal Study (CHARLS) is a nationally representative longitudinal survey of persons in China 45 years of age or older and their spouses, including assessments of social, economic, and health circumstances of community-residents. CHARLS examines health and economic adjustments to rapid ageing of the population in China. The national baseline survey for the study was conducted between June 2011 and March 2012 and involved 17 708 respondents. CHARLS respondents are followed every 2 years, using a face-to-face computer-assisted personal interview (CAPI). Physical measurements are made at every 2-year follow-up, and blood sample collection is done once in every two follow-up periods. A pilot survey for CHARLS was conducted in two provinces of China in 2008, on 2685 individuals, who were resurveyed in 2012. To ensure the adoption of best practices and international comparability of results, CHARLS was harmonized with leading international research studies in the Health and Retirement Study (HRS) model. Requests for collaborations should be directed to Dr Yaohui Zhao (yhzhao@nsd.edu.cn). All data in CHARLS are maintained at the National School of Development of Peking University and will be accessible to researchers around the world at the study website. The 2008 pilot data for CHARLS are available at: http://charls.ccer.edu.cn/charls/. National baseline data for the study are expected to be released in January 2013.
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Temporomandibular disorder
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To assess the clinical significance of a cervical cytological diagnosis of atypical glandular cells of undetermined significance and to formulate the most appropriate management guidelines for patients with such a diagnosis.Retrospective study.Regional hospital, Hong Kong.Seventy-two patients with diagnoses of atypical glandular cells of undetermined significance who were managed in a colposcopy clinic between January 1998 and December 1999.Age, cytological diagnoses of atypical glandular cells of undetermined significance and its subtypes, method of evaluation, final diagnosis, and outcome after 2 years.Atypical glandular cells of undetermined significance were diagnosed in 83 (0.4%) of 21 854 cervical smear samples taken during the 2-year study period. Follow-up data were available from 72 patients, whose mean age was 43 years (range, 22-69 years). Forty-three percent of these patients had significant diseases of the genital tract. Patients with the subtype diagnosis of atypical glandular cells of undetermined significance-favour neoplasia had the worst outcome, with 90% of patients having significant disease, followed by patients with atypical glandular cells of undetermined significance "not otherwise specified" (43%), and atypical glandular cells of undetermined significance-favour reactive (8%).Patients with atypical glandular cells of undetermined significance should be investigated early and thoroughly, because many of them will have premalignant or malignant disease.
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Depression during adolescence is associated with a number of negative outcomes in later life. Research has examined the longitudinal nature of adolescent depression in order to identify patterns of depressive mood, the early antecedents and later consequences. However, rich longitudinal data is needed to better address these questions. The Avon Longitudinal Study of Parents and Children (ALSPAC) is an intergenerational birth cohort with nine repeated assessments of depressive symptoms throughout late childhood, adolescence and young adulthood. Depressive symptoms are measured using the Short Mood and Feelings Questionnaire (SMFQ). Many studies have used ALSPAC to examine the longitudinal nature of depressive symptoms in combination with the wealth of early life exposure and later outcome data. This data note provides a summary of the SMFQ data, where the data are stored in ALSPAC, the characteristics and distribution of the SMFQ, and highlights some considerations for researchers wanting to use the SMFQ data in ALSPAC.
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