Features of men depressed patients with gastric ulcer and duodenal ulcer, with sexual disorders
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The objective: the evaluation of depressive state in men with peptic ulcer of stomach and duodenum, which have sexual disorders. Patients and methods. The study is based on the generalization of the results of complex examination and treatment of 130 patients with peptic ulcer disease duodenal ulcer in remission and gastric ulcer in remission who have sexual disorders; the first were 76 (58.5±4.3%) patients, the second – 54 (41.5±4.3%); p<0.05. They entered the main group. The comparison group consisted of 100 men with peptic ulcer disease duodenal ulcer and gastric ulcer that also in remission who did not complain of sexual disorders; accordingly, they were of 66.0±4.7% and 34.0±3.3%; p<0.05. The creation of this group are motivated by the need to determine the characteristics of changes in the quality of life, psychological status between patients with these somatic diseases, but if not combined with sexual disorders. For this purpose was used the referential group consisted of 20 healthy men, the survey results of which complements the existing normalized values most approximate to this population. All groups were matched for age, and the first two – for the duration of peptic ulcer disease. Results. It is determined that the frequency of manifestations of depression in patients with peptic ulcer disease duodenal ulcer and gastric ulcer with sexual disorders identified parameters, among which stood out significantly mental anxiety (85.4±3.1%), depressive mood (73.1±3.8%), somatic anxiety (66.1±4.3%), reduced efficiency and activity (64.6±4.1 percent). Their combination in various embodiments burdened the situation. Exclusively in patients with peptic ulcer disease were most prevalent somatic anxiety (32.0±4.6%), depressive mood (28,0±4,5%), capacity and activity (24.0±4.2%). It is revealed that most duodenal ulcer and gastric ulcer with sexual disorders (60.8±4.2%) characterized by a high level of personal anxiety and almost equally often low to moderate (19.2±3.4% and 20.0±3.4%, respectively). However, 93.0% of patients only with peptic ulcer were also noted its low level of expression. At the same time, among the first significantly more often observed the average level of situational anxiety (62.3±4.2%), every third – low (28.5±3.9%) and others (10.0 %) – high, whereas among second – frequency dominated low level (63.0±4.9% vs 31.0±4.9% of the average and 6.0±2.3% – high). Conclusion. It was confirmed the hypothesis of dependence between the presence of in patients with peptic ulcer disease various intensities of depression, mental tension, mainly situational anxiety and the development of sexual dysfunctions, as evidenced by the discovery in 14% of cases of erectile dysfunction. It was proven the principle of improving the early identification of sexual disorders in men with chronic somatic diseases, for example peptic ulcer disease, the essence of which – a mandatory inclusion in the medical history, as diagnostic method of two key parameters: the satisfaction of sexual intercourse and satisfaction with sexual life in General. Key words: gastric ulcer and duodenal ulcers, sexual function disorders, psychological disorders, and depression.Keywords:
Depression
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Objective It is to explore the experimental methodology of coordinate exercise of stomach and duodenum in body. Methods Hydrobladder was planted into the stomach and duodenum of cyanotic-blue rabbits. Then the stomach and duodenum movement on physiology, hypocinesia and hypercinesia conditions was recorded and analyzed with the system of computer-biology information. Results The recorded results of movement coordination of stomach and duodenum on three functional conditions conformed to those of theoretical expectation, and no difference was found ( P 0.05). Conclusion Hydrobladder plantation applies to experimental research of movement coordination of stomach and duodenum.
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An evaluation was made of the effects of increasing age on the mechanical properties and the collagen content of healing wounds in stomach and duodenum of rats. Wounds were made in the non-glandular (rumen) and the glandular oxyntic part (corpus)of the stomach and in the duodenum of rats that were 26 months old. The wounds were tested 7 and 20 days after the operation. The results of these tests were compared with those made on a group of young rats (3-4 months old) that were subjected similar wounds. Aging increased the stiffness and decreased the extensibility of tissue taken from intact stomach (rumen and corpus) and from wounded rumen. No differences in the stiffness and extensibility of the tissue from the duodenum wounds could be demonstrated. Except for a higher breaking strength in samples of rumen from old animals after 20 days of healing, no differences in mechanical strength measurements (breaking strength and breaking energy) from intact and wounded tissue could be demonstrated in the old and young animals. The collagen content of intact as well as wounded stomach tissues appeared related to age. No differences in the collagen content in the tissue from the duodenal wounds wee found. The dimensions of the biochemically active zone around the incision remained essentially unchanged in the duodenum and stomach and it was of the same width as that found for young animals. This indicates that aging has no adverse influence on wound healing in the stomach and the duodenum of rats.
Breaking strength
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Aim. Assessment of stomach and duodenal injury early after extended hemihepatectomy. Material and Methods. The experiment was performed on 100 white mongrel male rats. 80 of them underwent advanced hemihepatectomy, 20 animals consisted of control group. After 12 hours, 1, 3 and 7 days after surgery stomach and duodenum were histologically analyzed to detect chemiluminescent homogenates. Results. After 12 hours light sum and “fast” flash in the stomach were increased by 2.5 and 1.5 times, respectively, “slow” flash was decreased by 2 times. Growth of all parameters was observed in duodenum. There were significant decrease of “fast” flash and increase of light sum and “slow” flash in homogenates during 3 postoperative days. By the 7th day light sum was increased in stomach and duodenum, besides the duodenum increased “slow” flash. Structural changes were visualized after 12 hours in the form of erosions and ulcers of the stomach and duodenum. In 7 days reparative changes were predominant. Conclusion. In 12 hours after hemihepatectomy rapid activation of free-radical oxidation was observed in stomach and duodenum. Herewith inhibition of antioxidant enzymes have been already showed in stomach. Structural changes in the stomach (ulcers) have already been irreversible by this time. So, this period is critical for acute stomach and duodenal injury.
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A 38-year-old woman was treated for extensive corrosive injury of the stomach and duodenum following ingestion of liquid lye. Nine days following admission she developed perforation and bleeding from the stomach and duodenum. At operation the entire stomach and a large part of the duodenum were removed. Reconstruction of the gastrointestinal tract was accomplished by a staged procedure. Principles in management of extensive corrosive injury of the stomach and duodenum are discussed.
Perforation
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Предельно допустимые резекции печени являются операциями выбора у пациентов с очаговыми образованиями, при этом остается актуальной проблема язвенных желудочно-кишечных кровотечений после таких операций. В условиях периоперационного стресса активируются процессы свободнорадикального окисления, что оказывает повреждающий эффект на органы и ткани организма. Поэтому целью нашего исследования стала оценка параметров свободнорадикального окисления в желудке и двенадцатиперстной кишке в раннем послеоперационном периоде после предельно допустимой резекции печени с определением срока начальных изменений в этих органах. Методика. Исследование было выполнено на 70 белых беспородных крысах-самцах массой 200-230 г. Резекцию печени по оригинальной методике выполняли 60 животным, 10 интактных крыс составляли группу контроля. Через 6 часов, 12 часов, 1, 3, 7 и 30 суток извлекали желудок и двенадцатиперстную кишку для исследования хемилюминесценции гомогенатов, а также готовили гистологические препараты. Полученные результаты свидетельствуют о том, что активация процессов свободнорадикального окисления происходит уже через 12 часов после операции, при этом пик изменений приходится на срок 12 часов в двенадцатиперстной кишке, и на 1 сутки - в желудке. Структурные изменения в этих органах наблюдаются через 12 часов и проявляются формированием эрозий и язв. В желудке эти изменения необратимы, поскольку замещаются рубцом, а в двенадцатиперстной кишке обратимы, так как в позднем послеоперационном периоде замещаются практически зрелым эпителием. Maximum allowable liver resections are the operation of choice for patients with focal formations while the problem of ulcerative gastrointestinal bleeding after such operations remains relevant. Under the conditions of perioperative stress, free radical oxidation processes are activated and exert a detrimental effect on organs and tissues. Therefore, the aim of our study was to evaluate parameters of free radical oxidation in the stomach and duodenum in the early postoperative period after the maximum allowable liver resection and to determine the time of initial changes in these organs. The study was performed on 70 white outbred male rats weighing 200-230 g. Liver resection was performed according to the original method in 60 rats; the control group consisted of 10 intact rats. After 6, 12 h, 1, 3, 7, and 30 days, the stomach and duodenum were excised for a chemiluminescence study of homogenates and a histological study of preparations. Results of the study showed that the activation of free radical oxidation occurred already at 12 h after the surgery. The peak changes occurred at 12 h in the duodenum and at 24 h in the stomach. Structural changes in these organs were observed at 12 h and were evident as erosions and ulcers. In the stomach, these changes were irreversible, since they were replaced with a scar whereas in the duodenum, they were reversible, since they were replaced with almost mature epithelium in the late postoperative period.
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Endocrinology of the stomach and duodenum gastric acid secretion - control and regulation motility disorders of the stomach and duodenum immunology of the stomach and duodenum stomach and duodenum - injury, infections, and inflammation peptic ulcer helicobacter pylori gastroduodenal mucosal defence Zollinger-Ellison syndrome (gastrinoma) neoplasms of the stomach and duodenum vascular/bleeding lesions of the stomach and duodenum surgery of the stomach and duodenum.
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The purpose: to study the peculiarities of motor and evacuation functions of the stomach and duodenum in patients with peptic ulcer with associated chronic duodenal insufficiency (СDI). Materials and methods. The complex examination was carried out by 160 patients with ulcer disease (UD) with concomitant CDI (group 1) and 104 patients with no concomitant CDI (2nd group). The verification of UD was carried out by clinical and fibrogastroduodenoscopy studies. In the definition of CDI contrast duodenography and fibrogastroduodenoscopy were used. The evaluation of the motor-evacuation function (MEF) of the stomach and duodenum was carried out with the help of the peripheral electrogastroenterograph. Results of the study. In patients with UD with associated HDI before meals were identified bradygastria (75%) and hypertension (67%) of the stomach, and after eating the parameters of the electrical activity of the stomach in frequency and amplitude were decreased. We revealed hypokinesia (74%) and hypertension (52%) of duodenum on an empty stomach, postprandial frequency of it decreases compared with a thorough examination. The duodenogastric reflux is revealed in the fasting phase of the study. A segmenting and peristaltic contractions of the duodenum are slowed down, which is manifested in a decrease in the evacuation function of stomach and duodenum. Before meals in patients with UD without accompanying HDI were identified hypertension of the stomach (15%) and duodenum (68,95%), after a meal the indices of electrical activity of the stomach and duodenum were increased. In patients with duodenum ulcer of 1 group the electrical activity of duodenum before meals was corresponded to hyperkinetic (98.2%) and hypertensive (62.3%) type of the curve. The eating in patients of this group increases the peristaltic contractions of the longitudinal muscle layer of the duodenum, thereby accelerating the evacuation of the chyme without mixing it and disrupting the digestion process. In patients with duodenal ulcer without accompanying HDI before meals were identified the hypertension of the stomach (15%) and duodenum (68.95%), coordinated work of stomach and duodenum, as well as evacuation of food chyme were preserved. The conclusion. In patients with ulcer disease of stomach and duodenum with accompanying duodenal insufficiency, there was a violation of motor and evacuation activity of the stomach and duodenum both on an empty stomach and after eating, which adversely affects the course of ulcer disease.
Peristalsis
Migrating motor complex
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