Cytological features of metastatic ceruminous adenocarcinoma (not otherwise specified) in pleural effusion: A case report
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This is the first presentation of the cytological features of metastatic ceruminous adenocarcinoma (NOS) in a pleural effusion sample. Positive expression of SOX‐10 aided diagnosis in this case.Keywords:
Metastatic adenocarcinoma
Mean nuclear areas (MNA) were calculated morphometrically in ten cases of well-differentiated adenocarcinoma, ten cases of atypical alveolar cuboidal cell hyperplasia (AAH), and five cases of alveolar cuboidal cell hyperplasia (AH) and were compared with each other. In cases of adenocarcinoma, the MNA were significantly larger than those of AAH and AH, and the standard deviation (SD) of nuclear area was greater in adenocarcinoma than that in AAH and AH, thus implying greater "scatter" of the nuclear areas in the former than the latter two. The MNA and the SD of nuclear area in AH were smallest in these three groups. In one case each of AAH and adenocarcinoma, there were two different populations of nuclear size in the same lesions, that is, histograms showed both adenocarcinoma and AAH in the same tumor. Through the use of the morphometric method, many cases of AAH were easily distinguishable from adenocarcinoma cases, and there were two cases in which foci of adenocarcinoma and AAH coexisted.
Atypical adenomatous hyperplasia
Cuboidal Cell
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The disorders of skin pigmentation discussed in this chapter fall into two categories: disorders of hyperpigmentation (melasma, postinflammatory hyperpigmentation, drug-induced hyperpigmentation, erythema dyschromicum perstans, lentigines, confluent and reticulated papillomatosis of Gougerot and Carteaud, and Dowling-Degos disease) and disorders of hypopigmentation (vitiligo, albinism, piebaldism, and idiopathic guttate hypomelanosis). The definition, epidemiology, etiology and pathogenesis, diagnosis, differential diagnosis, and treatment are discussed for each condition. Figures show examples of melasma, hyperpigmentation secondary to acne, vitiligo and its response to treatment with tacrolimus and with narrow-band ultraviolet B (UVB) light, Vogt-Koyanagi-Harada syndrome, and piebaldism. A table lists therapeutic approaches to vitiligo. This chapter contains 182 references.
Vitiligo
Melasma
Hypopigmentation
Pigmentation disorder
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Erythema
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Hepatoid adenocarcinoma is a rare type of adenocarcinoma with hepatocellular differention, which is characterized by early metastatic spread and poor prognosis. The treatment strategy in not clearly defined due to an extreme rarity of the tumor. Surgery is the most effective tool as a part of multimodality concept. So far, only 51 cases have been described in the literature, and only one in Russia. Clinical case description. We report a case of metastatic hepatoid adenocarcinoma of the lung in a 54-year-old male patient. The difficulties in morphologic differential diagnosis between adenocarcinoma of the lung and primary liver cancer were described. The strategy for managing patients with hepatoid adenocarcinoma of the lung was demonstrated. Conclusion. Hepatoid adenocarcinoma of the lung is a rare tumor with unfavourable outcome.
Metastatic adenocarcinoma
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Introduction: Lung cancer is one of types of cancer as the highest death rate due to cancer in Indonesia. One of the clinical manifestations that can be caused by lung cancer is pleural effusion. Pleural effusion is a condition where there is an abnormal build up of fluid in the pleural cavity. Chest X-ray is one of the supporting examinations that play an important role in diagnosing pleural effusion. This study aims to see the incidence and characteristics of pleural effusion on thoracic imaging of lung cancer cases at RSUP Dr. Mohammad Hoesin Palembang. Method: This research method is descriptive using 108 medical record data of patients with a diagnosis of lung cancer who have the results of chest X-ray examination in 2019 at RSUP Dr. Mohammad Hoesin Palembang which is then performed re-identified of chest X-rays to determine the characteristics of pleural effusion. Results: From 108 study samples, 61 patients had pleural effusion. The highest age range in pleural effusion patients was 56-65 years (41%), more common in men (65,6%), and most patients were smokers (65,6%). Based on the findings of the chest X-ray, the most pleural effusion location was in the right side of the lung (44,3%) and the majority pleural effusion type is free pleural effusion (91,8%). Conclusion: The incidence of pleural effusion in lung cancer patients was 56,5% with the location of the most pleural effusions in the right lung field and the majority type of pleural effusion based on chest X-ray were free pleural effusion.
Pleural cavity
Thoracic cavity
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The disorders of skin pigmentation discussed in this chapter fall into two categories: disorders of hyperpigmentation (melasma, postinflammatory hyperpigmentation, drug-induced hyperpigmentation, erythema dyschromicum perstans, lentigines, confluent and reticulated papillomatosis of Gougerot and Carteaud, and Dowling-Degos disease) and disorders of hypopigmentation (vitiligo, albinism, piebaldism, and idiopathic guttate hypomelanosis). The definition, epidemiology, etiology and pathogenesis, diagnosis, differential diagnosis, and treatment are discussed for each condition. Figures show examples of melasma, hyperpigmentation secondary to acne, vitiligo and its response to treatment with tacrolimus and with narrow-band ultraviolet B (UVB) light, Vogt-Koyanagi-Harada syndrome, and piebaldism. A table lists therapeutic approaches to vitiligo. This chapter contains 182 references.
Vitiligo
Melasma
Hypopigmentation
Pigmentation disorder
Etiology
Lentigo
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Erysipelas
Intertriginous
Seborrheic Dermatitis
Etiology
Eczematous dermatitis
Folliculitis
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A 26-year-old woman with ovarian tumor underwent bilateral oophorectomy. Pre-operative examination showed massive ascites, obvious edema of the lower extremities and absence of pleural effusion. Immedi- ately after removal of massive ascites during the operation, sudden deterioration of SpO2 appeared. We treated it with addition of PEEP and furosemido i.v., and SpO2 improved. After the operation we recognized left sided massive pleural effusion on the chest X-ray picture, and we drained it. However, the next day we recognized right side massive pleural effusion. We suspect that the fluid pooled in the lower extremities shifted to produce pleural effusion for some reason or other.
Oophorectomy
Pleural disease
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This paper aims to determine the expression and clinical significance of DDX43 in lung adenocarcinoma. Expression of DDX43 gene and protein of lung adenocarcinoma tissue and para-carcinoma tissues was observed in 27 cases by RT-PCR and immunohistochemistry. These patients were diagnosed as lung adenocarcinoma in the Huaihe Hospital of Henan University from February 2015 to December 2015. The relative ratio of DDX43 mRNA expression in lung adenocarcinoma and para-carcinoma tissues was 0.87±0.62 versus 0.21±0.77 and the difference between the two groups was statistically significant (P<0.01). The expression of DDX43 in normal lung tissues and lung adenocarcinoma tissues was different. The positive rate of DDX43 expression in lung adenocarcinoma tissues was significantly higher than that in normal lung tissues, and the difference was statistically significant (P<0.05). The analysis of clinical pathological characteristics showed that the increase of protein expression was related to the stage and metastasis of lung adenocarcinoma. DDX43 is highly expressed in lung adenocarcinoma, and the expression level is related to the stage and metastasis of lung adenocarcinoma, suggesting that DDX43 is closely related to the occurrence and development of lung adenocarcinoma, and may be a molecular marker for early diagnosis of lung adenocarcinoma.
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Review of the histology of 219 lung cancers initially diagnosed at Lutheran General Hospital, Park Ridge, Illinois, in 1963-1967 and 1974-1976, confirms the increasing incidence of adenocarcinoma. This is due to an increase of adenocarcinoma in men. In women, the incidence of adenocarcinoma was higher than squamous carcinoma in the earliest period (44% adeno, 18% squamous). The percentage of women with lung cancer has also significantly increased from 19% to 31%, which increases the overall incidence of adenocarcinoma of the lung. As the number of women with lung carcinoma has increased, there has been no change in the percentage of adenocarcinoma in women.
Squamous carcinoma
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Adenocarcinoma는 상피유래의 점막을 비롯하여, 선조직이나 배설관에서 발생하는 종양으로 선조직, 피부를 포함하는 장기에서 발생한다. 원발병소를 찾지 못한 경부로 전이된 adenocarcinoma는 좀처럼 접하기 어려운 종앙이다. 경부로 전이된 종앙의 대부분은 squamous cell carcinoma이며. adenocarcinoma는 매우 드문 종앙이다, 일차병변을 찾지 못한 경부로 전이된 종앙 중 병리조직학적 진단이 이루어진 증례 중 약 81%가 squamous cell carcinoma이었으며, adenocarcinoma는 약 7.6%에 불과했다(Journal of Otolaryngology of Japan 2003;106(6):671-677).
Metastatic adenocarcinoma
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