Abstract:
We are in the midst of a revolution of knowledge regarding the human microbiome. The revolution comes from the explosion of knowledge on the role of our microbiomes in systemic disease, overall well-being, behavior, and many other health states that we previously would have never thought of microbiomes driving these complex states. Of all the complex microbiomes across the body, substantial evidence has shown that the gut microbiome appears to be the pivotal microbiome in the body. While there was always some sense of interactions between the microbiomes of the body, only recently has evidence built a fascinating picture of two- and three-way interactions between our microbiomes and organ systems. Now we are obtaining exciting data showing how one microbiome—the gut microbiome—has a definitive effect on the composition and metabolic activity of the skin microbiome. We are in a new era of discovery on how important our microbiomes are to our health and vitality. As we move into a new decade, more interactions and levels of regulation are sure to be discovered.Keywords:
Gut microbiome
Vitality
Gut microbiome
Intestinal Microbiome
Human Microbiome Project
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The study of the human microbiome or community of microorganisms and collection of genomes found in the human body is one of the fastest growing research areas because many diseases are reported to be associated with microbiome imbalance or dysbiosis. With the improvement in novel sequencing techniques, researchers are now generating millions of sequences of different sites from the human body and evaluating specific differences in microbial communities. The importance of microbiome constituency is so relevant that several consortia like the Human Microbiome project (HMP) and Metagenomics of the Human Intestinal Tract (MetaHIT) project are focusing mainly on the human microbiome. The aim of this review is to highlight points of research in this field, mainly focusing on particular factors that modulate the microbiome and important insights into its potential impact on our health and well-being.
Human Microbiome Project
Dysbiosis
Inflammatory Bowel Diseases
Human gastrointestinal tract
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Gut microbiome
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Diverse evidence has suggested that the gut microbiome is closely associated with overall human health. Modulation of the gut microbiome through nutritional intervention is recognized as a robust and attainable strategy to prevent disorders/diseases and improve human health. However, universal dietary recommendations demonstrated to have different, sometimes even opposite, effects due to the considerable inter-individual variability between subjects, especially in the gut microbiome. Hence, implementation of personalized nutrition or other treatment strategies have been suggested to tackle the individuality problem. A first step into this direction includes the stratification of subjects into specific groups based on their gut microbiome. The gut microbiome could serve as a pool of potential biomarkers for distinguishing "responders" and "non-responders" to specific treatments, which subsequently can be used to classify subjects with ambition to increase treatment efficacy. In this review, we explain the need for human gut microbiome stratification, introduce the concepts and show with specific examples potential options of microbiome-based stratifications. Finally, we propose a strategy for how microbiome-based stratification can be introduced to obtain improvements in dietary efficacy that can be implemented in real-life settings.
Gut microbiome
Human Microbiome Project
Risk Stratification
Stratification (seeds)
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The human microbiome, the collection of trillions of microbes living in and on the human body, is not random, and scientists believe that it plays a role in many basic life processes. As science continues to explore and better understand the identities and activities of the microbial species comprising the human microbiome, microbiologists hope to draw connections between microbiome composition, host genetics, and human health. FAQ: Human Microbiome addresses this growing area of research.
Human Microbiome Project
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Human Microbiome Project
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Gut microbiome
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Prebiotic
Gut microbiome
Intestinal Microbiome
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Gut microbiome
Intestinal Microbiome
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Citations (93)