Repeated introductions and intensive community transmission fueled a mumps virus outbreak in Washington State
Louise H. MonclaAllison BlackChas DeBoltMisty LangNicholas R. GraffAilyn C. Pérez-OsorioNicola F. MüllerDirk HaselowScott LindquistTrevor Bedford
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Abstract In 2016/2017, Washington State experienced a mumps outbreak despite high childhood vaccination rates, with cases more frequently detected among school-aged children and members of the Marshallese community. We sequenced 166 mumps virus genomes collected during outbreaks in Washington and other US states, and apply phylodynamic approaches to trace mumps introductions and transmission within Washington. We uncover that mumps was introduced into Washington at least 13 times, primarily from Arkansas, sparking multiple co-circulating transmission chains. Neither vaccination status nor age were strong determinants of transmission. Instead, the outbreak in Washington was overwhelmingly sustained by transmission within the Marshallese community. Our findings underscore the utility of genomic data to clarify epidemiologic factors driving transmission, and pinpoint contact networks as critical determinants of mumps transmission. These results imply that contact structures and historic disparities may leave populations at increased risk for respiratory virus disease even when a vaccine is effective and widely used.Keywords:
Mumps virus
The wild mumps virus which had been isolated from a patient suffering from mumps meningitis propagated biphasically in human lung cancer cell lines (Pc-3, Pc-10), while attenuated Urabe strain propagated monophasically. The early virus was detected in these cell lines when the cells were inoculated with the wild mumps virus at any multiplicity of infection but rapidly disappeared. The infectious virus, thereafter, could not be detected for about 20 days. However, the infectious virus appeared again and the titer of the virus in the culture fluid gradually increased. The late virus rapidly propagated in Pc-3 cells, while the early virus replicated in the same way as the original wild virus did. All of ten clones obtained from the original wild virus represented the biphasic growth in Pc-3 cells and the late virus was detected on the 25th-30th day after infection. The viral antigens in Pc-3 cells infected with wild virus did not disappear after cultivating under the presence of anti-mumps virus antibody for over 50 days. Furthermore, treatment of anti-mumps virus serum in the early period did not affect the appearance of the late virus. It is quite conceivable that the wild mumps virus might be able to persist in completely latent state and the adaptation of the virus to Pc-3 cells might progress during the latent period.
Mumps virus
Mumps vaccine
Viral culture
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Surveillance of general outbreaks of infectious gastroenteritis was introduced in 1998 by the Food Safety Authority of Ireland (FSAI), in co-operation with the eight health boards. A total of 67 general outbreaks of gastroenteritis in Ireland were reported to the FSAI in 1998 and 1999. Over 1900 people were ill as a result of these outbreaks. Four percent required hospitalisation and there were two deaths. The duration of the outbreaks varied between one day and 38 days. Salmonellae (44%) and small round structured viruses (SRSV) (12%) were the most commonly reported pathogens. In 25% of the outbreaks the aetiology was unknown. The commonest settings were restaurants, hotels and take-aways, which accounted for 45% (30/67) of all outbreaks. Sixteen percent of all outbreaks occurred in hospitals and residential institutions. Over half of the outbreaks were reported to be foodborne, 63% of which were due to various serotypes of Salmonella enterica. Eggs were implicated as the vehicle of infection in 13% of all outbreaks. An infected food handler was identified in almost one third of outbreaks, although it could not be established if this had contributed directly to the outbreak.
Salmonella Food Poisoning
Etiology
Salmonella enterica
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Etiology
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Infection of chick embryos wih either Newcastle disease virus or mumps virus and infection of BGM cell cultures with mumps virus result in the elaboration of chemotactic activity for neutrophils and macrophages. These factors cannot be found in lysates of uninfected cells. They do not appear to be associated with the viral particles per se, but rather are present in virus-free supernates from infected fluids. Ultracentrifugal studies of the neutrophil chemotactic activity in allantoic fluid of embryos infected with the two different viruses indicate a similar biphasic distribution of activity, while fluid from the mammalian cell cultures shows a single zone of leukotactic activity, further suggesting that the infected cell, rather than the virus, is responsible for the leukotactic activity. Virus-infected cells also release a substance(s) which is itself not leukotactic but which can interact with human C3 or C5 to generate such activity. This leukotactic factor-generating substance is similar to that reported in another virus-infected cell system. It is postulated that the leukotactic factors elaborated as a result of virus infection of cells may play a protective role in vivo.
Mumps virus
Newcastle Disease
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Abstract Enteroinvasive Escherichia coli (EIEC) outbreaks are uncommon in Europe. In June 2014, two EIEC outbreaks occurred in Nottingham, UK, within 2 days; outbreak A was linked to a takeaway restaurant and outbreak B to a wedding party. We conducted 2 analytical studies: a case–control study for outbreak A and a cohort study for outbreak B. We tested microbiological and environmental samples, including by using whole-genome sequencing. For both outbreaks combined, we identified 157 probable case-patients; 27 were laboratory-confirmed as EIEC O96:H19–positive. Combined epidemiologic, microbiological, and environmental findings implicated lettuce as the vehicle of infection in outbreak A, but the source of the organism remained unknown. Whole-genome sequencing identified the same organism in cases from both outbreaks, but no epidemiologic link was confirmed. These outbreaks highlight that EIEC has the capacity to cause large and severe gastrointestinal disease outbreaks and should be considered as a potential pathogen in foodborne outbreaks in Europe.
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Abstract Background The origins of Ebola disease outbreaks remain enigmatic. Historically outbreaks have been attributed to spillover events from wildlife. However, recent data suggest that some outbreaks may originate from human-to-human transmission of prior outbreak strains instead of spillover. Clarifying the origins of Ebola disease outbreaks could improve detection and mitigation of future outbreaks. Methods We reviewed the origins of all Ebola disease outbreaks from 1976 to 2022 to analyze the earliest cases and characteristics of each outbreak. The epidemiology and phylogenetic relationships of outbreak strains were used to further identify the likely source of each outbreak. Results From 1976 to 2022 there were 35 Ebola disease outbreaks with 48 primary/index cases. While the majority of outbreaks were associated with wildlife spillover, resurgence of human-to-human transmission could account for roughly a quarter of outbreaks caused by Ebola virus. Larger outbreaks were more likely to lead to possible resurgence, and nosocomial transmission was associated with the majority of outbreaks. Conclusions While spillover from wildlife has been a source for many Ebola disease outbreaks, multiple outbreaks may have originated from flare-ups of prior outbreak strains. Improving access to diagnostics as well as identifying groups at risk for resurgence of ebolaviruses will be crucial to preventing future outbreaks.
Ebolavirus
Ebola Hemorrhagic Fever
Spillover effect
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Mumps virus
Infectivity
Newcastle Disease
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Objective To understand the characteristics of influenza-like illness(ILI) outbreaks in Yunnan province and provide evidence for the development of scientific and effective control measures.Methods The data of ILI outbreaks in Yunnan in 2009 were collected and analyzed Results Totally 72 ILI outbreaks occurred in Yunnan,resulting in 7 628 ILI cases.The attack rate ranged from 1.79% to 49.45%.The disease occurred all the year round with peak in Autumn.Twenty six outbreaks occurred in Zhaotong,Sixty eight outbreaks occurred in schools.The influenza viruses were isolated from the cases in 37 out of 54 outbreaks,including influenza H3N2 virus(in 12 outbreaks),influenza B virus(in 11 outbreaks),2009 pandemic influenza A(H1N1) virus(in 9 outbreaks) and influenza A(H1N1) virus(in 5 outbreaks).The interval between the finding of the first case and the response and the duration of epidemic was positive correlated.(r=0.896,P0.05).Conclusion More ILI outbreaks occurred in Yunnan in 2009 than in 2008,and 94% of the outbreaks occurred in schools.It is necessary to strengthen the ILI outbreak surveillance and reporting in schools and improve the sample collection and laboratory detection.
Influenza-like illness
Attack rate
Pandemic
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SUMMARY In February 2007 an outbreak of Nipah virus (NiV) encephalitis in Thakurgaon District of northwest Bangladesh affected seven people, three of whom died. All subsequent cases developed illness 7–14 days after close physical contact with the index case while he was ill. Cases were more likely than controls to have been in the same room (100% vs . 9·5%, OR undefined, P <0·001) and to have touched him (83% vs . 0%, OR undefined, P <0·001). Although the source of infection for the index case was not identified, 50% of Pteropus bats sampled from near the outbreak area 1 month after the outbreak had antibodies to NiV confirming the presence of the virus in the area. The outbreak was spread by person-to-person transmission. Risk of NiV infection in family caregivers highlights the need for infection control practices to limit transmission of potentially infectious body secretions.
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All outbreaks of infectious intestinal disease reported to the authorities were entered on a computer database with outbreak control teams being established to investigate larger or more significant incidents. The outbreak database and, when set up, the notes of outbreak team meetings were examined for the 279 outbreaks reported in a three-year period (2003-2005). Faeces specimens submitted as part of an outbreak were examined for microbial pathogens and the results cross-matched to the outbreak number. Almost half of the general outbreaks reported (137) occurred in long-term care facilities for the elderly, 51 outbreaks were recorded in hospitals and 31 occurred in the wider community. In 76 outbreaks no specimen was logged. A microbial cause was confirmed in about one-third of outbreaks, with noroviruses being the most common (19%). Salmonellas accounted for 12 of the 21 community outbreaks linked to social events and all were foodborne. Suggestions for improving notification and surveillance are discussed.
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