A combined high-throughput and high-content platform for unified on-chip synthesis, characterization and biological screening
54
Citation
23
Reference
10
Related Paper
Citation Trend
Abstract:
Abstract Acceleration and unification of drug discovery is important to reduce the effort and cost of new drug development. Diverse chemical and biological conditions, specialized infrastructure and incompatibility between existing analytical methods with high-throughput, nanoliter scale chemistry make the whole drug discovery process lengthy and expensive. Here, we demonstrate a chemBIOS platform combining on-chip chemical synthesis, characterization and biological screening. We developed a dendrimer-based surface patterning that enables the generation of high-density nanodroplet arrays for both organic and aqueous liquids. Each droplet (among > 50,000 droplets per plate) functions as an individual, spatially separated nanovessel, that can be used for solution-based synthesis or analytical assays. An additional indium-tin oxide coating enables ultra-fast on-chip detection down to the attomole per droplet by matrix-assisted laser desorption/ionization mass spectrometry. The excellent optical properties of the chemBIOS platform allow for on-chip characterization and in-situ reaction monitoring in the ultraviolet, visible (on-chip UV-Vis spectroscopy and optical microscopy) and infrared (on-chip IR spectroscopy) regions. The platform is compatible with various cell-biological screenings, which opens new avenues in the fields of high-throughput synthesis and drug discovery.Keywords:
Characterization
Characterization
Cite
Citations (1)
Abstract This article provides a general introduction of materials characterization and describes the principles and applications of a limited number of techniques that are most commonly used to characterize the composition and structure of metals used in engineering systems. It briefly describes the classification of materials characterization methods including, bulk elemental characterization, bulk structural characterization, microstructural characterization, and surface characterization. Further, the article reviews the selection of materials characterization methods most commonly used with metals.
Characterization
Cite
Citations (0)
Characterization
Cite
Citations (2)
Characterization
Zeta potential
Cite
Citations (17)
Presents a method for analysis of automated highway throughput for AHS designs, including those with platooning. Simulation results are presented which show that increased information leads to higher throughput, and that a platooning design will have higher throughput than any individual vehicle design.
Cite
Citations (6)
This chapter contains sections titled: Introduction Modifications of PLA PLA Applications Characterization by FT-IR Characterization by Optical Microscopy Characterization by Electron Microscopy Characterization by Mechanical Testing Characterization of GPC Characterization of Dynamic Mechanical Thermal Analysis
Characterization
Polymer characterization
Cite
Citations (0)
This chapter contains sections titled: Geometrical Characterization Layer Thickness and Vertical Structure Dimensions Lateral Dimensions Structures that Assist Measurement Characterization of Composition of Layers and Surfaces Atomic Composition Characterization of the Chemical Surface Functional Characterization of Nanostructures
Characterization
Cite
Citations (0)
Materials characterization is a crucial issue in the development and application of new materials. Materials characterization aims to mine and acquire characteristic information and their evolution in the materials. It mainly includes three important topics which are microstructural characterization, properties characterization, and environmental degradation. In this paper, characterization techniques about these topics were discussed for C/SiC composites and a characterization system was preliminarily established. All these characterization research and their results further the better understanding of the relationship between microstructure and properties and of the failure mechanisms in the C/SiC composites.
Characterization
Cite
Citations (0)
This chapter contains sections titled: Introduction Characterization of Advanced Materials Physical Characterization of Advanced Materials Chemical Characterization of Advanced Materials Conclusions
Characterization
Cite
Citations (8)
This study is dedicated to investigate WLAN throughput based on 802.11 data communication standard which employs 2.4GHz band, depending on its AP channels and density. In a space with high density of WLANs, throughput can be decreased due to radio wave interferences. In light of this fact, an experiment scenario has been created consisting of multiple WLANs where throughput can be measured with different combination of channels, consequently making it possible to determine more effective combination of channels. In parallel, throughput has been recorded with varying the number of APs installed within the experiment site to Fig. out the relationship between the number of APs and the throughput. According to the result of the measurement, channel 1, 5, 9, and 13 are suggested as more effective combination of channels, and declining throughput is shown as AP density increases.
Cite
Citations (1)