Assessment of the Antioxidative Potential of Rosmarinus officinalis L. (Lamiaceae) Irrigated with Static Magnetic Field-Treated Water
Yilan Fung BoixAlbys Ferrer DuboisSophie HendrixLiliana Gómez LunaNatalie BeenaertsClara Esther Martínez ManriqueCristiane Pimentel VictórioAnn Cuypers
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Abstract:
Phenolic compounds are one of the main groups of secondary metabolites in plants and are known for their antioxidant activity. Rosmarinus officinalis L. (rosemary) contains different phenolic compounds including carnosol, carnosic acid and rosmarinic acid. In Cuba, rosemary cultivation is limited because it is difficult to propagate and has a low yield. As a result, it was removed from the Herbal Medicine National Formulary. However, the National Public Health System has a strong interest in rosemary because of its value as a natural antioxidant medicine. Irrigation with water treated with a static magnetic field (SMF) is a possible strategy to increase rosemary yield. This technology has been applied to accelerate plant growth and increase crop quality. The aim of this study was to evaluate the content of phenolic compounds and antioxidant activity in aqueous leaf extracts from plants irrigated with SMF-treated water in comparison to control plants. Significant differences in phenolic content and antioxidant activity were observed between aqueous extracts of control plants and plants irrigated with SMF-treated water. Therefore, irrigation with SMF-treated water is a promising technology to improve the cultivation of rosemary as a raw material to obtain pharmaceutical products with high antioxidant activities.Keywords:
Rosmarinus
Rosmarinic acid
Carnosic acid
Rosmarinus officinalis is one of the important bioactive medicinal plants belongs to labiatae family. The aim is to identifying the essential oil and rosmarinic acid extracted from rosemary leaves and to evaluate its anti bacterial activity. Gas Chromatography-Mass analysis was performed for essential oil of rosemary and HPTLC analysis was done for 90% methanolic extract of rosemary leaves. Rosmarinic acid was detected and The essential oil content was 1.5% and characterized with high amount of 1,8 cineol (53.63%) . The zone of inhibition of some bacteria was estimated. Our findings showed that rosemary leaves has Good percentage of rosemary phytochemicals (essential oil and rosmarinic acid) and has significant antibacterial activity against different species of bacteria.
Rosmarinus
Rosmarinic acid
Phytochemical
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Rosemary, Rosmarinus officinalis, one of two species in the genus Rosmarinus, is a woody, perennial herb with fragrant, evergreen, needle-like leaves and white, pink, purple or blue flowers, native to the Mediterranean region.It is a member of the mint family Lamiaceae which includes many other herbs.Rosemary is used as a decorative plant in gardens and has many culinary and medical uses.The leaves are used to flavor various foods, like stuffings and roast meats.Rosemary contains antioxidant compounds such as carnosic acid, rosmarinic acid (RA) apart from other bioactive compounds including camphor, caffeic acid, ursolic acid, betulinic acid, rosmaridiphenol and rosmanol 1-3 .Some of these compounds have shown positive results and may be useful in preventing or treating cancer, strokes and Alzheimer's disease.Researchers have reported that the plants are a source of several compounds having antioxidant 4 , antiinflammatory 5 , antiallergy 6 and antidepressive 7 activities.Phenolic compounds have also been reported amongst which, rosmarinic acid an ester of caffeic acid and 3,4dihydroxyphenylacetic acid are the most important compounds 8 .Rosmarinic acid from Rosmarinus officinalis is elucidated to be an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid 9 .Because of the antioxidant activity of Lamiaceaeous herbs in laboratory test models they have been suggested to Comparative Extraction and Downstream Processing Techniques for Quantitative Analysis of Rosmarinic Acid in Rosmarinus officinalis
Rosmarinus
Rosmarinic acid
Downstream processing
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Carnosic acid
Rosmarinus
Callus
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The concentration of carnosic acid in a representative selection of leaves from wild and cultivated populations of Rosmarinus officinalis was determined by reversed-phase HPLC following extraction with supercritical carbon dioxide. Different sources of variability including season, genetics, leaf age, and growing origin (wild or cultivated) were considered. Variability in the carnosic acid content among rosemary leaves appears to be largely due to seasonal and environmental factors, in addition to their individual origin (genetics). The results reveal excellent correlation (r = 0.93) between the carnosic acid concentration and photoperiod. The results presented can be used to improve the selection of raw materials for the extraction of carnosic acid from rosemary. Keywords: Rosmarinus officinalis; carnosic acid; antioxidant; supercritical fluid extraction
Carnosic acid
Rosmarinus
Supercritical Carbon Dioxide
Rosmarinic acid
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The distribution of six compounds with three different polyphenol skeletons have been studied in Rosmarinus officinalis: phenolic diterpenes (carnosic acid, carnosol, and 12-O-methylcarnosic acid), caffeoyl derivatives (rosmarinic acid), and flavones (isoscutellarein 7-O-glucoside and genkwanin), each showing a characteristic behavior and distribution during the vegetative cycle. Only in leaves were all six compounds present, and the highest accumulation rate was related with the young stages of development. Rosmarinic acid showed the highest concentrations of all the polyphenols in all organs. The distribution of this acid in leaves, flowers, and stems suggests that in the first stages of flower growth, levels were due to in situ biosynthesis, and in the last stages, the contribution of transport phenomena was increased. The antioxidant activity of six extracts with different polyphenolic composition was evaluated in aqueous and lipid systems. The results clearly suggest that rosemary extracts are excellent antioxidants in both aqueous and lipid systems.
Rosmarinus
Rosmarinic acid
Flavones
Gentiana
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Methods were developed to identify and select accessions of rosemary, Rosmarinus officinalis (L.), producing optimum antioxidant activity. Extracts from 12 different rosemary accessions, using three solvents of varying polarity, were assayed for their antioxidant activity, and their major antioxidant compounds were identified and quantified by high-performance liquid chromatography (HPLC). Carnosic acid concentrations were correlated with (i) the free radical scavenging activity of these extracts, as measured by the 2,2-diphenyl-1-picrylhydrazyl assay (adjusted R2 = 77.3%) and (ii) their inhibition of linoleic acid oxidation, as measured by the β-carotene assay (adjusted R2 = 44.1%). The correlation was broadly confirmed by the production of volatile aldehydes as measured by the hexanal assay. The variation of carnosic acid concentrations in extracts of 29 accessions, grown in field trials at three sites in England, was determined. Keywords: Antioxidants; β-carotene; carnosic acid; DPPH•; rosemary; rosmarinic acid
Carnosic acid
Rosmarinus
Rosmarinic acid
Camphene
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Carnosic acid
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Objective To establish an HPLC method to determine the content of rosmarinic acid and carnosic acid in Rosmarinus officinalis L.Methods Phenomenex C18(250 mm×4.60 mm,5 μm) at 30 ℃ was used.The mobile phase was acetonitrile(A)-0.1% phosphoric(B): 0-10 min: 25%A;10-15 min: 25%-75%A;and 15-25 min: 75%A.The flow rate was 1.0 mL min-1.The detection wavelength was 284 nm.Results Rosmarinic acid and carnosic acid were well isolated from other components,and the calibration curve showed a good linear correlation at 0.046 55-1.86 20 μg and 0.372 7 14.908 μg.The average recovery was 99.0%(RSD = 1.1%,n = 9) and 98.1%(RSD = 1.5%,n = 9).Conclusion The method is simple,accurate and reliable for the determination of rosmarinic acid and carnosic acid in Rosmarinus officinalis L.
Carnosic acid
Rosmarinic acid
Rosmarinus
Phosphoric acid
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The present study is aimed to the effect of a Tunisian aromatic plant Rosmarinus officinalis extract on - a neuronal cell model - PC12 cells and on HSP47. The extract of R. officinalis and two pure compounds rosmarinic acid and carnosic acid promote markedly the neurite outgrowth of PC12 cells and enhanced the acetylcholinesterase activity same as NGF (neurite outgrowth factor). The investigation of phosphorylation marker illustrates that Rosemary extract treatment showed ERK1/2 phosphorylation same as NGF. Moreover, Rosmarinus extracts and its pure compounds have shown a stress recovery activity on HSP47.
Rosmarinus
Carnosic acid
Rosmarinic acid
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