Prevalence of SARS-CoV-2 Antibodies in Health Care Personnel in the New York City Area
Joseph MoscolaGrace SembajweMark JarrettBruce F. FarberTylis Y. ChangThomas McGinnKarina W. Davidson
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Abstract:
This seroprevalence survey study describes severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity among health care workers at a New York City–based health system by age, sex, race, county of residence, and prior PCR-confirmed viral exposure.Keywords:
Seroprevalence
2019-20 coronavirus outbreak
Coronavirus
Spike protein is the most important membrane protein on the surface of SARS (Severe Acute Respiratory Syndrome) coronavirus. It associates with cellular receptors to mediate infection of their target cells. Inspired by this, this paper studies the genome sequences of S protein and SARS's receptor based on Z curve method. A kind of visualizing characteristics for SARS coronavirus is seized in this study. The results, derived from the comparisons among a large number of genome sequences, have proved that this kind of characteristics is special for SARS coronavirus. The characteristic maps can be used in the detection of SARS coronavirus to provide a nonstandard, simple and visualized detection approach, especially for the situation where the standard method's results are conflict. From this study, we have also viewed that Z curve initiates an effective way for analyzing gene sequences using a geometric approach.
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spike protein
2019-20 coronavirus outbreak
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Coronavirus
2019-20 coronavirus outbreak
spike protein
Sars virus
Feature (linguistics)
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A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (M~(pro), also called 3CL~(pro)), controlling the activities of the coronavirus replication complex, represents an attractive target for therapy. A homology model for SARS coronavirus (SARS-CoV) M~(pro), which is based on crystal structures for human coronavirus (strain 229E) M~(pro) and for an inhibitor complex of porcine coronavirus (transmissible gastroenteritis virus, TGEV) M~(pro) are reviewed. The structures reveal a remarkable degree of conservation of the substrate-binding sites, which is further supported by recombinant SARS-CoV M~(pro)-mediated cleavage of a TGEV M~(pro) substrate. Molecular modeling suggests that available rhinovirus 3C~(pro) inhibitors may be modified to make them useful for SARS therapy.
Coronavirus
Nidovirales
Coronaviridae
Rhinovirus
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An antigen detection assay for severe acute respiratory syndrome (SARS) coronavirus was established in this study by an indirect immunofluorescence test, which utilized cells derived from throat wash samples of patients with SARS and a rabbit serum that recognized the nucleocapsid protein of SARS-associated coronavirus (SARS-CoV) but not that of other human coronavirus tested. It detected SARS-CoV in 11 of 17 (65%) samples from SARS patients as early as day 2 of illness but in none of the 10 samples from healthy controls. Compared with other diagnostic modalities for detecting SARS-CoV, this assay is simpler, more convenient, and economical. It could be an alternative for early and rapid diagnosis, should SARS return in the future.
Immunofluorescence
Coronavirus
Throat
2019-20 coronavirus outbreak
Betacoronavirus
Coronaviridae
Sars virus
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The article presents some introductory remarks on viruses and in general how they lead to diseases. With reference to same, it discusses the emergence of a fairly novel coronavirus, 2019- CoV-2 and its possible medication.
Coronavirus
2019-20 coronavirus outbreak
Sars virus
Betacoronavirus
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[Objective] To further compare Bat SARS coronavirus with coronaviruses of human and civets, in order to explore their similarities. [Methods] A system anagenesis relation among Bat SARS coronavirus, Human SARS coronavirus, and Civet SARS coronavirus was explored in present study, and a genetic sequence map was drawn. Additionally, a 3D model of S protein and N protein was predicted. [Results] The sequence analysis showed that Bat SARS coronavirus was with highly similarity as SARS coronaviruses of human and palm civets. The system anagenesis analysis demonstrated that Bat-SARS-CoV and SARS-CoV formed a group called Group 2b CoV, which was distant to Group 2 CoV. [Conclusion] It is not very possible that Bat SARS coronavirus HKU3-1 was not transmitted from Human SARS coronavirus, but Bat SARS coronavirus and Civet SARS coronavirus may share the same origin, which implies Bat SARS coronavirus might still be infectious to human.
Coronavirus
Betacoronavirus
Coronaviridae
2019-20 coronavirus outbreak
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A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (M pro , also called 3CL pro ), which controls the activities of the coronavirus replication complex, is an attractive target for therapy. We determined crystal structures for human coronavirus (strain 229E) M pro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (TGEV)] M pro , and we constructed a homology model for SARS coronavirus (SARS-CoV) M pro . The structures reveal a remarkable degree of conservation of the substrate-binding sites, which is further supported by recombinant SARS-CoV M pro -mediated cleavage of a TGEV M pro substrate. Molecular modeling suggests that available rhinovirus 3C pro inhibitors may be modified to make them useful for treating SARS.
Coronavirus
2019-20 coronavirus outbreak
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The nucleocapsid protein sequence of the SARS coronavirus was purified and iden- tified by using proteomics technology. The LC MS/MS result showed that the SARS coronavirus and the other coronavirus have the same motif “FYYLGTGP”.
Coronavirus
Coronaviridae
2019-20 coronavirus outbreak
Structural protein
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Identification of the function of SARS coronavirus proteins facilitates the development of therapeutics for treatment of SARS coronavirus infection. We report the identification of the function of some SARS coronavirus proteins by using a Support Vector Machine Program SVMProt. The predicted function of two SARS coronavirus proteins with known function is in agreement with existing knowledge, which indicates the usefulness of SVMProt in functional prediction of SARS coronavirus proteins as well as other proteins. We predict the function of a SARS coronavirus protein with unknown function, ORF13, to be a nuclear protein and a structural protein with probable DNA binding property.
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Identification
Protein function prediction
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