A032 Association of Gut and Oral Microbiomes in Acute Coronary Syndrome With Blood Markers of Gut Leakage, Inflammation and Coronary Artery Disease Risk
0
Citation
0
Reference
10
Related Paper
Keywords:
Lachnospiraceae
The gut microbiota and related metabolites are positively regulated by soluble dietary fiber (SDF). In this study, we explored the effects of SDF from pear pomace (PP) on the regulation of gut microbiota and metabolism in high-fat-diet-fed (HFD-fed) C57BL/6J male mice. The results showed that PP-SDF was able to maintain the HFD disrupted gut microbiota diversity with a significant increase in Lachnospiraceae _UCG-006, Akkermansia , and Bifidobacterium spp. The negative effects of high-fat diet were ameliorated by PP-SDF by regulating lipid metabolisms with a significant increase in metabolites like isobutyryl carnitine and dioscoretine. Correlation analysis revealed that gut microbiota, such as Akkermansia and Lachnospiraceae _UCG-006 in the PP-SDF intervention groups had strong positive correlations with isobutyryl carnitine and dioscoretin. These findings demonstrated that PP-SDF interfered with the host's gut microbiota and related metabolites to reduce the negative effects caused by a high-fat diet.
Akkermansia
Lachnospiraceae
Pomace
Akkermansia muciniphila
Cite
Citations (11)
Gut microbiota has been identified as a key player in the development of alcoholic liver disease (ALD). Targeting gut microbiota with probiotic intervention will be an attractive approach to prevent ALD. Here, we investigated the effects of probiotic Bifidobacterium breve ATCC15700 (ATCC15700) on liver injury and gut microbiota in mice exposed to chronic alcohol intake. Our results showed that oral administration of ATCC15700 significantly decreased endotoxemia, maintained immune homeostasis, and alleviated alcohol-induced liver injury. ATCC15700 also promoted intestinal barrier function by enhancing the expressions of tight junction proteins in alcohol-treated mice. Moreover, analysis of gut microbiota showed that ATCC15700 normalized the structure and composition of the alcohol-disrupted gut microbiota. Correlation between gut microbiota and liver injury parameters revealed that specific bacteria, including S24_7, unclassified Clostridiales, Butyricicoccus, Oscillospira, Ruminococcus, Mucispirillum and unclassified Lachnospiraceae, were predominantly associated with ALD. In conclusion, ATCC15700 protected alcohol-exposed mice against liver injury via modulating gut micobiota.
Lachnospiraceae
Bifidobacterium breve
Ruminococcus
Liver disease
Chronic liver disease
Cite
Citations (48)
Gut microbiota have recently been suggested to play a part in low-grade systemic inflammation, which is considered a key risk factor for cardiometabolic disorders. Diet is known to affect gut microbiota; however, the effects of diet and dietary components on gut microbiota and inflammation are not fully understood. In the present review, we summarize recent research on human dietary intervention studies, investigating the effects of healthy diets or dietary components on gut microbiota and systemic inflammation. We included 18 studies that reported how different dietary components altered gut microbiota composition, short-chain fatty acid levels, and/or inflammatory markers. However, the heterogeneity among the intervention studies makes it difficult to conclude whether diets or dietary components affect gut microbiota homeostasis and inflammation. More appropriately designed studies are needed to better understand the effects of diet on the gut microbiota, systemic inflammation, and risk of cardiometabolic disorders.
Cite
Citations (82)
Diet-induced obese
Cite
Citations (179)
Lachnospiraceae
Dysbiosis
Royal Jelly
Cite
Citations (14)
Alterations in the gut microbiota have been associated with a wide range of pathologies and conditions. Maintaining a well-balanced microbiota is a key factor in sustaining good health. Our aim was to investigate the impact of a resistant starch-containing dietary supplement (SymbioIntest) on the composition of the human gut microbiota and on intestinal short chain fatty acid (SCFA) concentration. Human microbiota-associated mice were used. Ex-germ-free mice were inoculated with faecal suspensions from four different donors. Three weeks later, the mice were orally gavaged for one month with either a daily dose of 10 mg of SymbioIntest or the vehicle (water) for the negative control group. The composition of the microbiota and SCFA levels were analysed by 16S rRNA gene sequencing and gas chromatography, respectively. In three groups of mice, SymbioIntest supplementation increased the concentration of caecal butyrate. This was in conjunction with a remodelling of the gut microbiota. OTUs belonging to the Bacteroidaceae, Porphyromonadaceae, Lachnospiraceae and Ruminococcaceae families were affected. In two groups of mice the greatest changes in OTUs were seen in the Faecalibacterium genus. The supplementation's highest impact was observed in mice inoculated with gut microbiota containing a lower number of Ruminococcaceae and Faecalibacterium and a higher number of Prevotellaceae. SymbioIntest supplementation elicited a beneficial effect on the healthy adult gut microbiota by increasing caecal butyrate production and health-promoting taxa. We highlight the fact that screening the gut microbiota may be used for predicting individualized responses to dietary interventions and thus developing personalized nutritional strategies.
Resistant Starch
Prebiotic
Caecum
Dietary fibre
Western diet
Cite
Citations (24)
Age-related macular degeneration (AMD) is a leading cause of blindness world-wide. Although the etiology of AMD is multifactorial, diet and nutrition have strong epidemiologic associations with disease onset and progression. Recent studies indicate a role for gut microbiota in development of AMD in mouse models and in some forms of human AMD. We previously found that consuming lower glycemia diets is associated with protection against AMD in humans and switching from higher to lower glycemia diets arrests AMD phenotypes in mice. Gut microbiota populations and circulating microbial cometabolites were altered in response to dietary carbohydrates, indicating a gut-retina axis. Here we explore additional gut microbiota-AMD interactions that point toward pathogenic roles for some gut microbiota families, including Ruminococcaceae and Lachnospiraceae, and individual members of Turicibacteraceae, Clostridiaceae, and Mogibacteriaceae. We also speculate on potential mechanisms by which gut microbiota influence AMD, with the objective of devising new AMD diagnoses and treatments.
Lachnospiraceae
Gut–brain axis
Cite
Citations (37)
Abstract Type 2 diabetes mellitus (T2DM), a chronic metabolic disease which severely impairs peoples’ quality of life, currently attracted worldwide concerns. There are growing evidences that gut microbiota can exert a great impact on the development of T2DM. Xiexin Tang (XXT), a traditional Chinese medicine prescription, has been clinically used to treat diabetes for thousands of years. However, few researches are investigated on the modulation of gut microbiota community by XXT which will be very helpful to unravel how it works. In this study, bacterial communities were analyzed based on high-throughput 16S rRNA gene sequencing. Results indicated that XXT could notably shape the gut microbiota. T2DM rats treated with XXT exhibited obvious changes in the composition of the gut microbiota, especially for some short chain fatty acids producing and anti-inflammatory bacteria such as Adlercreutzia , Alloprevotella , Barnesiella , [ Eubacterium ] Ventriosum group , Blautia , Lachnospiraceae UCG-001 , Papillibacter and Prevotellaceae NK3B31 group . Additionally, XXT could also significantly ameliorate hyperglycemia, lipid metabolism dysfunction and inflammation in T2DM rats. Moreover, the correlation analysis illustrated that the key microbiota had a close relationship with the T2DM related indexes. The results probably provided useful information for further investigation on its active mechanism and clinical application.
Lachnospiraceae
Eubacterium
Akkermansia
Cite
Citations (219)
An increasing amount of evidence suggests that the metabolic improvement of high-fat diet (HFD)-induced obese mice by Fuzhuan brick tea (FBT) is associated with gut microbiota. However, the causalities between FBT and gut microbiota have not yet been elucidated and the underlying mechanisms of action remain unclear. To impart direct evidence for the essential role of gut microbiota in the attenuation of obesity by FBT, the effects of FBT on healthy mice and microbiota-depleted mice that were treated with antibiotics were compared in an HFD-induced obesity mouse model. The results showed that FBT dramatically ameliorated obesity, serum lipid parameters, blood glucose homeostasis, hepatic steatosis, adipocyte hypertrophy, and tissue inflammation. However, the microbiota-depleted mice with single bacterium (Escherichia-Shigella) after antibiotic treatment were resistant to FBT-induced antiobesity and metabolic improvement. The beneficial effects of FBT resulted from its shift on gut microbiota composition and structure in mice. HFD-induced increase in the phyla Firmicutes/Bacteroidetes (F/B) ratio was remarkably restored by FBT. Furthermore, FBT-induced increase in abundances of beneficial bacteria Clostridiaceae, Bacteroidales, and Lachnospiraceae and decreases in harmful Ruminococcaceae, Peptococcaceae, Peptostreptococcaceae, and Erysipelotrichaceae were causal antecedents for FBT to reduce obesity and improve metabolic disorders.
Lachnospiraceae
Dysbiosis
Cite
Citations (106)